2005
DOI: 10.1590/s0102-86502005000700015 View full text |Buy / Rent full text
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Abstract: This effect was probably due to products present in this drug that may complex with ions (Sn(+2) and 99mTcO4) or have a direct or indirect effect on intracellular stannous ion concentration.

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“…Thus a great deal of the chemistry done in the design of diagnostic radiopharmaceuticals has been technetium chemistry 6 . Several natural or synthetic drugs can interfere with the biological behavior of radiopharmaceuticals, used in scintigraphy examinations, or on the labeling of blood constituents with technetium-99m 6,7,8 . They can change the biological effect of the radiopharmaceutical and their interaction can lead to hypo or hyper uptake of radiopharmaceuticals in a particular organ, causing incorrect diagnosis or misinterpretation of results.…”
Section: Introductionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Thus a great deal of the chemistry done in the design of diagnostic radiopharmaceuticals has been technetium chemistry 6 . Several natural or synthetic drugs can interfere with the biological behavior of radiopharmaceuticals, used in scintigraphy examinations, or on the labeling of blood constituents with technetium-99m 6,7,8 . They can change the biological effect of the radiopharmaceutical and their interaction can lead to hypo or hyper uptake of radiopharmaceuticals in a particular organ, causing incorrect diagnosis or misinterpretation of results.…”
Section: Introductionmentioning
“…They can change the biological effect of the radiopharmaceutical and their interaction can lead to hypo or hyper uptake of radiopharmaceuticals in a particular organ, causing incorrect diagnosis or misinterpretation of results. Repeated scintigraphy may result in unnecessary radiation for patients 6,7,8 . Although Aloe vera is a natural product used by many people, orally or topically, little is known about its action mechanism, its effects on host cells and toxicity.…”
Section: Introductionmentioning
“…The labelling capacity of these isotopes for the plasmatic proteins is well known, and their bioavailability and pharmacokinetics can be modifi ed by drugs and diseases 1,2 . Among the most useful artifi cial radioisotopes, technetium-99m, in the chemical form of sodium pertechnetate (Na 99m Tc0 4 ), is the most important.…”
Section: Introductionmentioning
“…Many factors, such as drug therapy, radiation therapy, surgery, in addition to the pathological process, could affect the biodistribution of different radiopharmaceuticals [13][14][15] . In this work, when Sm-153-EDTMP was administered to rats previously treated with docetaxel, the biodistribution of the radiopharmaceutical to bone, kidney, liver and lung was significantly lower than that of controls.…”
Section: Discussionmentioning