The Effect of Globin Powder on Bone Mineral Density in Model Rats with Postmenopausal Osteoporosis.

Abstract

Insufficient intake of calcium is one of the risk factors for osteoporosis.Recently, many studies have investigated calcium sources and various food components influencing calcium metabolism. In this study, the bone mineral density (BMD) of the lumbar spine and tibia was measured by dual energy X-ray absorptiometry (DEXA) in order to examine the effect of globin powder, a polypeptide mixture (average M.W., 8000), on bone metabolism in model rats with postmenopausal osteoporosis. Six-week-old SD-strain female rats were ovariectomized and were fed a low-Ca diet (0.01% Ca and 0.3% P) for 32 days. Thereafter, the rats were divided into 2 groups: a control group fed a control diet (18% casein, 0.3% Ca and 0.3% P) and a globin group fed a globin diet (18% casein, 0.24% globin, 0.3% Ca and 0.3% P) for 27 days. In comparison with the control group, the globin group showed significant increases in (1) the BMD of the lumbar spine and tibia, (2) the Ca content of the femur, (3) the breaking force and energy of the femur, and (4) femoral bone weight.Furthermore, the Ca absorption in the globin group was higher than in the control group. These results suggest that globin powder could be effective for the prevention of bone loss in postmenopausal osteoporotic rats.Key Words bone mineral density, calcium content in femur, breaking force, breaking energy.

Impacto dos nutrientes na saúde óssea: novas tendências

“…Deve-se levar em consideração, no momento do planejamento dietético, não somente a proporção Ca/P da dieta, como também a origem (animal ou vegetal) do P dietético para prevenção/tratamento da osteoporose (36) .…”

The Nutritional Evaluation of Globin on Maintenance of Bone Metabolism in Ovariectomized Osteoporotic Rats.

“…We have reported that the globin preparation might elevate intestinal Ca absorption (10). On the other hand, in the bone from vitamin D-deficient rats, either there is no osteoinductive activity or there is a smaller amount of osteoinduc tive activity.…”

“…We have reported that a dietary globin preparation is effective for increasing bone mineral density (BMD) and physical bone strength in experimental animals (10). The globin powder is thought to be effective in increasing intestinal Ca absorption (10).…”

“…The globin powder is thought to be effective in increasing intestinal Ca absorption (10). However, the detailed mechanism of the effect is still unclear.…”

The Effect of Spiny Lobster Shell Powder on Bone Metabolism in Ovariectomized Osteoporotic Model Rats.

“…The muscles and connective tissues were carefully removed. Thereafter the bone mineral density (BMD) of the fourth and fifth lumbar vertebrae (L4, L5) were measured by dual energy X-ray absorptiometry [DEXA (Hologic's QDR-1000 X-ray bone densitometer)] as previously reported (7). Moreover, whole tibias were measured by DEXA.…”