The effect of Ginkgo biloba and Nifedipine on DNA breaks in circulating leukocytes of glaucoma patients

Fang, Lei; Neutzner, Albert; Turtschi, Stephanie; Mozaffarieh, Maneli

doi:10.1586/17469899.2015.1043994

Cited by 7 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, treatment with GB extract was able to increase the survival of a rat RGC line, following exposure to oxidative stress induced by hydrogen peroxide (H 2 O 2 ) [96]. Furthermore, POAG patients treated with 120 mg of GB extract daily for at least 6 months demonstrated a lower rate of single-stranded DNA breaks in circulating leukocytes, indicating reduced oxidative stress [97].…”

Section: Gingko Biloba Lmentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

View full text Add to dashboard Cite

Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

show abstract

Section: Gingko Biloba Lmentioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Vascular regulation can be improved by carbonic anhydrase inhibitors [24,25], calcium channel blockers and magnesium, a physiological calcium channel blocker [26]. Increased retinal venous pressure can also be lowered by treatment with calcium channel blockers [27,28]. Increased oxidative stress, particularly at the level of the optic nerve, can be decreased by administering ginkgo biloba and potentially by intake of nutrition rich in sources of polyphenolic flavonoids and anthocyanosides [29,30] (Figure 3).…”

Section: Therapeutic Interventions Beyond Lowering Iopmentioning

confidence: 99%

Managing Glaucoma beyond Intraocular Pressure

Fischer

Mozaffarieh

2019

CTOY

Self Cite

View full text Add to dashboard Cite

Glaucoma is a major cause of vision loss worldwide with nearly 8 million people bilaterally blind from the disease. This number is estimated to increase over the next years. The key to preventing blindness from glaucoma is effective diagnosis and treatment. The classical glaucoma treatment focuses on IOP reduction. Increased IOP is indeed an undisputable risk factor for the development and progression of Glaucomatous Optic Neuropathy (GON). But there is mounting evidence in literature that other risk factors are involved as well. These additional factors may by themselves lead to GON or they may render the eye more sensitive to IOP. Among the most often described factors are: Flammer-syndrome, low blood pressure, increased retinal venous pressure, oxidative stress. Better knowledge of the pathogenesis has opened up additional therapeutical approaches often called non-IOP lowering treatment. Whilst most of these new avenues of treatment are still in the experimental phase, others are already used by some physicians. Non-IOP lowering treatment includes improvements of ocular blood flow, particularly blood flow regulation. This can be achieved by improving the regulation of ocular blood flow (improving auto regulation) by drugs such as carbonic anhydrase inhibitors, magnesium or calcium channel blockers. These drugs also in part decrease increased retinal venous pressure in the eyes of patients. Increased retinal venous pressure decreases perfusion pressure in the patients’ eyes and thus increases the risk of glaucomatous progression. The patients’ blood pressure also needs to be monitored carefully as low blood pressure, particularly nocturnal over dips or blood pressure fluctuations, increase the risk of further damage. Blood pressure can be increased by an increase in salt intake or in rare cases by treatment with fludrocortisone. Reduction of oxidative stress, especially at the level of mitochondria, also seems to be protective. This can be achieved by gingko or foods rich in polyphenolic flavonoids.This review describes the individual mechanisms which may be targeted by non-IOP lowering treatment.

show abstract

“…This property of ginkgo allows protection against retinal ischemia-reperfusion injury [52][53][54]. Gingko extracts inhibit LDL oxidation [55,56], have a relaxing effect on vascular walls [57], increase ocular blood flow velocity in patients [58,59], reduce systemic oxidative stress in glaucoma patients [12] (Fig. 5), and slow visual field progression in normal-tension glaucoma patients [60,61].…”

Section: Ginkgo Bilobamentioning

confidence: 99%

“…In Europe, we are slowly going to where the Eastern culture has been for hundreds of years back to the idea that food is medicine and that we cannot disassociate our health with what we eat. As ophthalmologists, we are doing no harm to the patient by providing them with additional information on nutrition and lifestyle for the following reasons: it is cheap, well accepted by the patient as it has a natural source and supports the FS patient with their subjective symptoms with some first studies showing objective improvements in measures such as increased retinal venous pressure [5,6], decreased systemic oxidative stress or improvements in peripheral blood flow [12][13][14]. It is important to note, however, that nutritional recommendations for people with FS are quite different than those with a metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Nutritional recommendations for individuals with Flammer syndrome

et al. 2017

Self Cite

View full text Add to dashboard Cite

The Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness or emotional stress.The question whether such people should be treated is often discussed. On the one hand, most of these subjects are healthy; on the other hand, FS seems to predispose to certain eye diseases such as normal tension glaucoma or retinitis pigmentosa or systemic diseases such as multiple sclerosis or tinnitus. A compromise between doing nothing and a drug treatment is the adaption of nutrition. But what do we mean by healthy food consumption for subjects with FS? The adaption of nutrition depends on the health condition. Whereas patients with e.g. a metabolic syndrome should reduce their calorie intake, this can be counterproductive for subjects with FS, as most subjects with FS have already a low body mass index (BMI) and the lower the BMI the stronger the FS symptoms. Accordingly, while fasting is healthy e.g. for subjects with metabolic syndrome, fasting can even dangerously aggravate the vascular dysregulation, as it has been nicely demonstrated by the loss of retinal vascular regulation during fasting. To give another example, while reducing salt intake is recommended for subjects with systemic hypertensions, such a salt restriction can aggravate systemic hypotension and thereby indirectly also the vascular regulation in subjects with FS. This clearly demonstrates that such a preventive adaption of nutrition needs to be personalized.

show abstract

The effect of Ginkgo biloba and Nifedipine on DNA breaks in circulating leukocytes of glaucoma patients

Cited by 7 publications

References 37 publications

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Managing Glaucoma beyond Intraocular Pressure

Nutritional recommendations for individuals with Flammer syndrome

Contact Info

Product

Resources

About