Nutritional recommendations for individuals with Flammer syndrome

Vahedian, Zakieh; Fakhraie, Ghasem; Bovet, Jérôme; Mozaffarieh, Maneli

doi:10.1007/s13167-017-0093-7

Cited by 8 publications

(7 citation statements)

References 106 publications

(117 reference statements)

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“…PACG is a common cause of blindness, and its complexity has long plagued clinicians [19]. Because of its chronic nature, the progression of PACG brings with it severe living, economic and psychological burdens to the patients, and most importantly, a decrease in vision that affects their quality of life [20][21][22]. Therefore, it is essential to identify the factors that initiate and contribute to the pathogenesis and progression of PACG.…”

Section: Discussionmentioning

confidence: 99%

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

et al. 2019

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The red blood cell distribution width (RDW) is a simple and inexpensive laboratory parameter that can be linked to oxidative stress, inflammation and microvascular flow resistance. For this research, we performed a large-sample case-control study to describe the relationships between the RDW and primary angle-closure glaucoma (PACG). A total of 1191 PACG patients (422 males and 769 females), who were divided into mild, moderate and severe PACG groups, and 982 healthy controls (344 males and 638 females) were recruited between January 2008 and June 2018. Detailed eye and physical examinations were performed for each subject. Based on the laboratory results, the mean RDW was significantly higher (p < 0.001) in the PACG group (13.01 ± 0.82%) than in the control group (12.65 ± 0.53%). Moreover, the mean RDW level was lower (p < 0.05) in the mild PACG group than in the moderate and severe PACG groups. The Pearson correlation analyses showed significant positive correlations between the mean deviation and the RDW (r = 0.141, p < 0.001) and the intraocular pressure and the RDW (r = 0.085, p = 0.004). After adjusting for the confounding factors, the logistic regression analyses indicated that the odds ratio for the PACG group was 2.318 (p < 0.001, 95% confidence interval 1.997, 2.690) when compared to the control group. Additionally, an increased RDW was associated with the PACG severity, and this trend was also observed in the gender and age subgroups. In summary, the results of our study showed that an elevated RDW was associated with PACG and its severity. If future studies confirm this relationship, the use of an RDW assessment may help to predict the PACG severity in each patient in order to better customise effective prevention treatments.

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Section: Discussionmentioning

confidence: 99%

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

et al. 2019

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“…Ponadto osoby z FS powinny rzucić palenie, ponieważ nikotyna zmniejsza przepływ krwi w naczyniach siatkówki i prowadzi do uogólnionego wzrostu stresu oksydacyjnego. Ze względu na niskie ciśnienie krwi obserwowane u osób z FS zaleca się wzrost spożycia soli (Vahedian et al, 2017). Dieta pacjentów z FS powinna być bogata w produkty z wysoką zawartością antyoksydantów, takie jak: kawa, herbata, czerwone wino, miłorząb dwuklapowy, ogórecznik, niebieskie owoce i jagody, kwasy tłuszczowe omega-3, kakao (Vahedian et al, 2017).…”

Section: Leczenieunclassified

“…Ze względu na niskie ciśnienie krwi obserwowane u osób z FS zaleca się wzrost spożycia soli (Vahedian et al, 2017). Dieta pacjentów z FS powinna być bogata w produkty z wysoką zawartością antyoksydantów, takie jak: kawa, herbata, czerwone wino, miłorząb dwuklapowy, ogórecznik, niebieskie owoce i jagody, kwasy tłuszczowe omega-3, kakao (Vahedian et al, 2017). Leczenie farmakologiczne polega na podawaniu magnezu w dawce 10-20 mmol dziennie.…”

Section: Leczenieunclassified

Flammer syndrome – characteristics and prevalence among multiple sclerosis patients

Pikora¹,

Jamiołkowska²,

Janosz³

et al. 2022

Aktualn Neurol

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Flammer syndrome, which has been described in literature only recently, combines two basic components: primary vascular dysregulation and symptoms not directly related to vascular function (prolonged sleep onset time, low pain threshold or specific personality traits). Some health-protective effects, such as a reduced risk atherosclerosis and metabolic syndrome, have also been noted. Flammer syndrome most often coexists with ocular diseases, normal tension glaucoma in particular, as well as with neurological disorders, such as multiple sclerosis. Diagnosis is based on a detailed physical examination; however, standardised diagnostic methods are missing. A three-component therapeutic strategy, including appropriate lifestyle, proper nutrition and pharmacotherapy in the form of magnesium preparations or low-dose calcium channel blockers, is used for Flammer syndrome. Clinical studies in 2016 and 2019 showed that multiple sclerosis patients are significantly more likely to develop typical symptoms of Flammer syndrome compared to controls. These included dizziness, low body weight, non-migraine headaches, reduced feeling of thirst, prolonged sleep onset time, and a tendency towards perfectionism. Although the aetiology of Flammer syndrome and multiple sclerosis or the causes underlying the clinical correlations between them have not been clarified so far, expanded research may contribute to better care for those at increased risk of developing multiple sclerosis, as well as improved therapy and support for patients, with consideration given to challenges that may arise from the coexistence of both diseases.

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“…Increased retinal venous pressure can also be lowered by treatment with calcium channel blockers [27,28]. Increased oxidative stress, particularly at the level of the optic nerve, can be decreased by administering ginkgo biloba and potentially by intake of nutrition rich in sources of polyphenolic flavonoids and anthocyanosides [29,30] (Figure 3).…”

Section: Therapeutic Interventions Beyond Lowering Iopmentioning

confidence: 99%

Managing Glaucoma beyond Intraocular Pressure

Fischer

Mozaffarieh

2019

CTOY

Self Cite

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Glaucoma is a major cause of vision loss worldwide with nearly 8 million people bilaterally blind from the disease. This number is estimated to increase over the next years. The key to preventing blindness from glaucoma is effective diagnosis and treatment. The classical glaucoma treatment focuses on IOP reduction. Increased IOP is indeed an undisputable risk factor for the development and progression of Glaucomatous Optic Neuropathy (GON). But there is mounting evidence in literature that other risk factors are involved as well. These additional factors may by themselves lead to GON or they may render the eye more sensitive to IOP. Among the most often described factors are: Flammer-syndrome, low blood pressure, increased retinal venous pressure, oxidative stress. Better knowledge of the pathogenesis has opened up additional therapeutical approaches often called non-IOP lowering treatment. Whilst most of these new avenues of treatment are still in the experimental phase, others are already used by some physicians. Non-IOP lowering treatment includes improvements of ocular blood flow, particularly blood flow regulation. This can be achieved by improving the regulation of ocular blood flow (improving auto regulation) by drugs such as carbonic anhydrase inhibitors, magnesium or calcium channel blockers. These drugs also in part decrease increased retinal venous pressure in the eyes of patients. Increased retinal venous pressure decreases perfusion pressure in the patients’ eyes and thus increases the risk of glaucomatous progression. The patients’ blood pressure also needs to be monitored carefully as low blood pressure, particularly nocturnal over dips or blood pressure fluctuations, increase the risk of further damage. Blood pressure can be increased by an increase in salt intake or in rare cases by treatment with fludrocortisone. Reduction of oxidative stress, especially at the level of mitochondria, also seems to be protective. This can be achieved by gingko or foods rich in polyphenolic flavonoids.This review describes the individual mechanisms which may be targeted by non-IOP lowering treatment.

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Nutritional recommendations for individuals with Flammer syndrome

Cited by 8 publications

References 106 publications

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

Flammer syndrome – characteristics and prevalence among multiple sclerosis patients

Managing Glaucoma beyond Intraocular Pressure

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