The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Ebrahimzadeh, Armin; Ebrahimzadeh, Anahita; Mirghazanfari, Sayid Mahdi; Hazrati, Ebrahim; Hadi, Saeid; Milajerdi, Alireza

doi:10.1016/j.ctim.2022.102802

Cited by 19 publications

(26 citation statements)

References 41 publications

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“…The other eight studies even though showed insignificant results, but the average results of HbA1c levels in the intervention group all decreased so that in total from the forest plots there was a significant decrease in HbA1c levels in the intervention group compared to placebo. The results of this study are in line with research conducted by Ebrahimzadeh et al, (2022) and Huang et al, (2019) which proved that the administration of ginger powder can reduce HbA1c levels in type 2 DM patients. Ginger powder for 8-12 weeks in type 2 DM patients can reduce HbA1c levels compared to placebo.…”

Section: Discussionsupporting

confidence: 90%

“…This significant value is influenced by several factors, including in all primary study groups the average value in the intervention group is smaller than the placebo group so that the cumulative SMD leads to intervention. The results of this study are in line with the research conducted by Ebrahimzadeh et al, (2022) which proved that the administration of ginger powder can reduce the GDP levels of type 2 DM patients. However, this study is not in line with the research conducted by Huang et al, (2019) which states that ginger powder has no significant effect on GDP levels in type 2 DM patients.…”

Section: Discussionsupporting

confidence: 90%

“…significantly compared to those receiving placebo. Another study by Ebrahimzadeh et al, (2022) also proved that the administration of ginger powder can reduce GDP levels in type 2 DM patients. However, this study is not in line with the RCT research conducted by Arablou et al, (2014), Arzati et al, (2017), Carvalho et al, (2020, Gholinezhad et al, (2020), Khandouzi et al, (2015), Mahluji et al, (2013), Mozaffari-Khosravi et al, ( 2014, and another study by Huang et al, (2019) which stated that ginger powder had no significant effect on GDP levels in type 2 DM patients.…”

Section: Discussionmentioning

confidence: 88%

“…The results of this study are in line with RCT studies conducted by El Gayar et al, (2019), Shidfar et al, (2015), Arablou et al, (2014), Gholinezhad et al, (2020), and other studies. by Ebrahimzadeh et al, (2022) and Huang et al, (2019) who proved that the administration of ginger powder can reduce HbA1c levels in type 2 DM patients. This provides stronger evidence that the administration of ginger powder for 8-12 weeks in Type 2 DM patients can lower HbA1c levels compared to placebo.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Zingiber officinale Rhizome Powder on Fasting Blood Sugar Levels and HbA1c in Type 2 Diabetes Mellitus Patients: A Meta-Analysis

Novianto

Tamtomo²,

Prasetya³

2022

INDONES J MED

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Background: Diabetes mellitus (DM) type 2 is the most common type of diabetes caused by insulin resistance and relative deficiency of insulin secretion. Several studies have shown inconsistent results regarding the effect of Zingiber officinale powder in patients with type 2 DM. As a result of these inconsistencies, researchers are compelled to prove the effect of Zingiber officinale powder on fasting blood sugar (GDP) and HbA1c levels in type 2 DM patients through a meta-analysis study. Subject and Method:This study is a meta-analysis of a number of randomized controlled trials. The articles were obtained from the PubMed, Science Direct, Springerlink and Google Scholar databases published in 2012-2022. The search articles were carried out by considering the feasibility of the criteria determined using the PICO model. Population: type 2 DM patients, Intervention: Zingiber officinale rhizome powder, Comparison: placebo, Outcome: GDP and HbA1c levels. The keywords used are "Zingiber officinale" OR "Zingiber" OR "Z. officinale" OR "Ginger" AND "Fasting blood glucose" AND "HbA1c" OR "A1c" OR "Glicemic" OR "Glucose" OR "Diabetes Mellitus" OR "type 2 diabetes mellitus" AND "Randomized Controlled Trial". Article selection with PRISMA flow diagram. Analysis of articles using the Revman 5.3 application. Results: A total of 11 articles were reviewed in this study. Analysis of 11 articles showed that administration of Zingiber officinale rhizome powder could significantly reduce GDP levels in type 2 DM patients (Standardized Mean Difference (SMD)= -0.79; 95% CI= -1.32 to -0.26; p= 0.004). Analysis of 10 articles showed that administration of Zingiber officinale rhizome powder could significantly reduce HbA1c levels (SMD = -0.38; 95% CI= -0.55 to -0.22; p<0.001). Conclusion: Zingiber officinale rhizome powder can significantly reduce GDP and HbA1c levels in type 2 DM patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Zingiber officinale Rhizome Powder on Fasting Blood Sugar Levels and HbA1c in Type 2 Diabetes Mellitus Patients: A Meta-Analysis

Novianto

Tamtomo²,

Prasetya³

2022

INDONES J MED

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“…A recent meta-analysis in type 2 diabetic patients pooled the results of five papers on the topic and concluded that ginger consumption has no significant positive effect on any of the lipid profile components (Ebrahimzadeh et al, 2022); however, in our study, we pooled the results of nine studies on the effect of ginger on lipids in type 2 diabetic patients. In contrast to their findings, we found that TG was much lower in these patients after ginger consumption.…”

Section: Discussionmentioning

confidence: 94%

Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta‐analysis

Salih

Alwan²,

Khadim

et al. 2023

Phytotherapy Research

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Dyslipidemia is associated with an increased risk of cardiovascular events. Effect of ginger supplementation on lipid profile in humans remains controversial particularly in diabetic patients. A systematic search was performed covering PubMed, Medline, and Scopus, Web of Science (ISI), and Google scholar from January 2010 to January 2022. Inclusion criteria were randomized controlled clinical trials (RCT) study design, at least one of lipid profile components triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) measured before and after ginger consumption. For quantitative data synthesis, a random-effects model was applied. Pooled data showed that ginger intake reduced TC (SMD À0.44; 95% CI: À0.86, À0.02; p = 0.025) and TG (SMD -0.61; 95% CI: À1.14, À0.08; p = 0.024) levels significantly, but it has no significant effect on improving HDL-C (SMD 0.40; 95% CI: À0.01, 0.80; p = 0.057) and LDL-C (SMD À0.34; 95% CI: À0.81, 0.13; p = 0.153). Ginger supplementation decreased TG in obese and diabetic subjects more efficiently. In terms of ginger dose, the result of meta-regression found to be significant only for TC, so that increasing daily doses of ginger reduces TC levels by (β: À0.67; 95% CI: À1.28, À0.07; p = 0.028). Therefore, ginger could be considered as an effective lipid lowering nutraceuticals.

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The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis

Schumacher,

Mueller,

Sousa

et al. 2024

Clinical Nutrition ESPEN

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The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

Cited by 19 publications

References 41 publications

Effect of Zingiber officinale Rhizome Powder on Fasting Blood Sugar Levels and HbA1c in Type 2 Diabetes Mellitus Patients: A Meta-Analysis

Effect of Zingiber officinale Rhizome Powder on Fasting Blood Sugar Levels and HbA1c in Type 2 Diabetes Mellitus Patients: A Meta-Analysis

Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta‐analysis

The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis

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