The effect of genistein on cisplatin induced ototoxicity and oxidative stress

Tan, Mehmet; Toplu, Yüksel; Varan, Emrah; Sapmaz, Emrah; Özhan, Onural; Parlakpınar, Hakan; Polat, Alaadin

doi:10.1016/j.bjorl.2021.07.001

Cited by 7 publications

(1 citation statement)

References 29 publications

(23 reference statements)

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“…P53 protein, one of the most important tumor suppressor proteins, is often abnormally expressed in most human tumors [ 44 ] When the expression of P53 was up-regulated the induction of ROS was increased so the ROS is considered one of the initiator of apoptosis in the cells [45 ] Cerium oxide down-regulated the mRNA of P53 in our current work while [46 ]showed that the cerium oxide may activated the P53 and induced apoptosis Cisplatin made direct inactivation of P53 and interfere with the DNA of the cells via formation of cross link and directly decreased apoptosis [47,48 ]who support that cisplatin made P53 stabalization in the cells.…”

Section: Discussionmentioning

confidence: 57%

Evaluation of antitumor efficacy of Cerium oxide nanoparticle on Ehrlich tumour cells in mice

2023

JPTCP

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The goal of the current study was to assess the anticancer effects of cisplatin and cerium oxide nanoparticles on tumours caused by Ehrlich tumour cells in the skeletal muscles of female mice. The Ehrlich solid carcinoma bearing female mice were divided into 5 groups, control group Ehrlich solid carcinoma bearing mice were administered deionized dist. water for two weeks, Group 2 orally administered with ( 5%CeNPs) Group 3: orally administered with ( 10%CeNPs) Group 4: orally administered with ( 20%CeNPs) Group 5: Ehrlich solid carcinoma bearing mice were injected intraperitoneal with Cisplatin (1 mg/kg) daily for two weeks. Antioxidant parameters, comet assay, histopathology, and mRNA expression of (P53 and K-ras ) genes were evaluated. The tumour mass was consisted of sheets and clusters of neoplastic cells with small areas of necrosis. The addition of cerium oxide nanoparticles lead to diminished the tumour masses and appearance of apoptotic holes. In the first group, the present study found higher levels of malondialdehyde (MDA) and decreased activity of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD). The addition of 20% CeNPs resulted in a drop in MDA and an increase in SOD, while the activity of the GPx enzymes increased. The K-Ras gene was up-regulated by the CeNPs, but the P53 gene was down-regulated. Cisplatin also showed similar results to cerium oxide nanoparticles but less prominent. The cerium oxide nanoparticle had antitumor efficacy as that of the cisplatin with low side effects on the tissues.

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Section: Discussionmentioning

confidence: 57%

Evaluation of antitumor efficacy of Cerium oxide nanoparticle on Ehrlich tumour cells in mice

2023

JPTCP

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Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Gupta

Kumar³

et al. 2023

ChemistrySelect

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Genistein is a natural isoflavone and a phytoestrogen known to possess broad range of pharmacological properties specifically explored for anticancer effects. The compound is under clinical trials for different types of cancer treatment. Structural modification of genistein has been done to prepare analogs with improved anticancer potential and pharmaceutical properties. Also, novel formulations of genistein have been developed to further improve water solubility and bioavailability for better clinical effectiveness. In the present review, we have summarized the recent available literature on genistein anticancer effects along with mechanism of action and clinical trial studies, reported analogs and novel formulations developed for improving the anticancer efficacy of genistein during the period 2013–2022. Also, the structure activity relationship (SAR) study of reported genistein analogs is described. Further, articles published in this period showed that both genistein and its various derivatives exhibit promising potential for the development of effective chemotherapeutic agents against different types of cancer. Further, the present review will help the researchers in design and development of genistein formulation with desired drug profile.

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Ototoxicity among cisplatin, carboplatin, and oxaliplatin in zebrafish model

Li,

Zhao,

Cheng

et al. 2024

Environmental Toxicology

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Platinum‐based antineoplastic drugs, including cisplatin, carboplatin, and oxaliplatin, are widely used in the treatment of various cancers. Ototoxicity is a common adverse effect of platinum‐based drugs. Ototoxicity leads to irreversible hearing impairment. We hypothesize that different platinum‐based drugs exhibit varying ototoxic concentrations, time effects, and ototoxic mechanisms. We tested this hypothesis by using a zebrafish model (pvalb3b: TagGFP) to assess the viability of hair cells collected from zebrafish larvae. Cisplatin, carboplatin, and oxaliplatin were administered at dosages of 100, 200, or 400 μM, and the ototoxic effects of these drugs were assessed 1, 2, or 3 h after administration. Fm4‐64 and a TUNEL assay were used to label the membranes of living hair cells and to detect cell apoptosis, respectively. We observed that >50% of hair cells were damaged at 1 h after cisplatin (100 μM) exposure, and this ototoxic effect increased at higher dosages and over time. Owing to the smaller ototoxic effects of carboplatin and oxaliplatin, we conducted higher‐strength and longer‐duration experiments with these drugs. Neither carboplatin nor oxaliplatin was obviously ototoxic, even at 1600 μM and after 6 h. Moreover, only cisplatin damaged the membranes of the hair cells. Cell apoptosis and significantly increased antioxidant gene expression were observed in only the cisplatin group. In conclusion, cisplatin significantly damages sensory hair cells and has notable dosage and time effects. Carboplatin and oxaliplatin are less ototoxic than cisplatin, likely due to having different ototoxic mechanisms than cisplatin.

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The effect of genistein on cisplatin induced ototoxicity and oxidative stress

Cited by 7 publications

References 29 publications

Evaluation of antitumor efficacy of Cerium oxide nanoparticle on Ehrlich tumour cells in mice

Evaluation of antitumor efficacy of Cerium oxide nanoparticle on Ehrlich tumour cells in mice

Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Ototoxicity among cisplatin, carboplatin, and oxaliplatin in zebrafish model

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