2008
DOI: 10.1016/j.biomaterials.2007.12.029
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The effect of gelatin incorporation into electrospun poly(l-lactide-co-ɛ-caprolactone) fibers on mechanical properties and cytocompatibility

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Cited by 184 publications
(126 citation statements)
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“…There have been several controversial reports about the incorporation of natural polymers, such as collagen and gelatin, and how these polymers can influence the mechanical properties of composite nanofibers. [11] Through the comparative experiment using gelatin as a control natural polymer, we also found similar reinforcing tendency that the tensile strength and Youngs modulus were increased, and elongation was decreased by addition of gelatin (more than 30 %) into PCL/gelatin nanofibers. However, their tensile strengths were about half of the values measured for the PCL/fp-151 nanofibers (see Figure S2b in the Supporting Information).…”
supporting
confidence: 57%
“…There have been several controversial reports about the incorporation of natural polymers, such as collagen and gelatin, and how these polymers can influence the mechanical properties of composite nanofibers. [11] Through the comparative experiment using gelatin as a control natural polymer, we also found similar reinforcing tendency that the tensile strength and Youngs modulus were increased, and elongation was decreased by addition of gelatin (more than 30 %) into PCL/gelatin nanofibers. However, their tensile strengths were about half of the values measured for the PCL/fp-151 nanofibers (see Figure S2b in the Supporting Information).…”
supporting
confidence: 57%
“…Many natural and synthetic polymers have been used to form fibers separately or as composites, and mixtures of organic polymers with inorganic particles have also been fabricated [11][12][13]. For example, Lee et al reported that fibroblasts cultured on gelatin blended with poly(L-lactide-co-3-caprolactone) (PLCL) fibers are useful for skin regeneration [14] and poly(L-lactide) combined with nanosized bone powder demonstrated improved mineralization of pre-osteoblastic cells [15].…”
Section: Introductionmentioning
confidence: 99%
“…A PLCLhybrid gelatin scaffold was reported to show improvement of cell viability and mechanical properties according to the gelatin contents (Lee et al 2008). Therefore, we studied to modify the hybridization method to be more simple and economic using collagen.…”
Section: Introductionmentioning
confidence: 99%