The Effect of Gamma-Ray-Induced Central Nervous System Injury on Peripheral Immune Response: An In Vitro and In Vivo Study

Zhang, Peng; Chen, Yu; Zhu, Huiyang; Yan, Liben; Sun, Chunli; Pei, Sizhu; Lodhi, Adil Farooq; Ren, Haitao; Gao, Yanan; Manzoor, Robina; Li, Bo; Deng, Yulin; Ma, Hong

doi:10.1667/rr15378.1

Cited by 10 publications

(3 citation statements)

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“…The results suggested that the changes in TNF-α in the developed inflammatory model were more pronounced and consistent with the trend reported in the literature. 39–42 Additionally, these results further illustrated the complex biological phenomena manifested in the neuroinflammatory model, and the co-culture model may have greater biological significance for studying disease inflammation.…”

Section: Resultsmentioning

confidence: 77%

Neuroinflammatory response on a newly combinatorial cell–cell interaction chip

Zhao,

Lv,

Chen

et al. 2024

Biomater. Sci.

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Section: Resultsmentioning

confidence: 77%

Neuroinflammatory response on a newly combinatorial cell–cell interaction chip

Zhao,

Lv,

Chen

et al. 2024

Biomater. Sci.

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“…Inflammation has been shown to be an important mechanism for the progression of most common diseases [ 5 ]. Among the various important biological indicators, semicarbazide sensitive amino oxidase (SSAO), expressed in most tissues and organs [ 6 , 7 ], has been shown to have a close relationship with these inflammatory responses [ 8 , 9 , 10 , 11 ]. Some studies have revealed that the sequence of vascular adhesion protein-1 (VAP-1) is consistent with the cDNA of SSAO [ 12 ], showing the same distribution and mode of action.…”

Section: Introductionmentioning

confidence: 99%

The Biological Implication of Semicarbazide-Sensitive Amine Oxidase (SSAO) Upregulation in Rat Systemic Inflammatory Response under Simulated Aerospace Environment

Yan

Sun

Zhang

et al. 2023

IJMS

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The progress of space science and technology has ushered in a new era for humanity’s exploration of outer space. Recent studies have indicated that the aerospace special environment including microgravity and space radiation poses a significant risk to the health of astronauts, which involves multiple pathophysiological effects on the human body as well on tissues and organs. It has been an important research topic to study the molecular mechanism of body damage and further explore countermeasures against the physiological and pathological changes caused by the space environment. In this study, we used the rat model to study the biological effects of the tissue damage and related molecular pathway under either simulated microgravity or heavy ion radiation or combined stimulation. Our study disclosed that ureaplasma-sensitive amino oxidase (SSAO) upregulation is closely related to the systematic inflammatory response (IL-6, TNF-α) in rats under a simulated aerospace environment. In particular, the space environment leads to significant changes in the level of inflammatory genes in heart tissues, thus altering the expression and activity of SSAO and causing inflammatory responses. The detailed molecular mechanisms have been further validated in the genetic engineering cell line model. Overall, this work clearly shows the biological implication of SSAO upregulation in microgravity and radiation-mediated inflammatory response, providing a scientific basis or potential target for further in-depth investigation of the pathological damage and protection strategy under a space environment.

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“…Along with that, RT-induced lymphodepletion and subsequent suppression of immune response contribute to the insufficient efficiency of conventional RT and may be limiting the success of GBM treatment ( 15 ). Also, irradiation affects the expression of microRNA ( 16 ) and numerous biomarkers related to inflammation, DNA damage and repair, cell activation and damage, angiogenesis pathways, which are involved in the pathogenesis of GBM and its radioresponse ( 17 , 18 ). Latest knowledge on radiation-induced genetic and epigenetic changes as well as a role of reactive oxygen species (ROS), GBM heterogeneity, and tumor microenvironment (TME) in brain tumor biology is presented in the comprehensive review by Raviraj et al ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Radiation Effects on Brain Extracellular Matrix

Grigorieva

2020

Front. Oncol.

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Radiotherapy is an important therapeutic approach to treating malignant tumors of different localization, including brain cancer. Glioblastoma multiforme (GBM) represents the most aggressive brain tumor, which develops relapsed disease during the 1st year after the surgical removal of the primary node, in spite of active adjuvant radiochemotherapy. More and more evidence suggests that the treatment's success might be determined by the balance of expected antitumor effects of the treatment and its non-targeted side effects on the surrounding brain tissue. Radiation-induced damage of the GBM microenvironment might create tumor-susceptible niche facilitating proliferation and invasion of the residual glioma cells and the disease relapse. Understanding of molecular mechanisms of radiation-induced changes in brain ECM might help to reconsider and improve conventional anti-glioblastoma radiotherapy, taking into account the balance between its antitumor and ECM-destructing activities. Although little is currently known about the radiation-induced changes in brain ECM, this review summarizes current knowledge about irradiation effects onto the main components of brain ECM such as proteoglycans, glycosaminoglycans, glycoproteins, and the enzymes responsible for their modification and degradation.

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The Effect of Gamma-Ray-Induced Central Nervous System Injury on Peripheral Immune Response: An In Vitro and In Vivo Study

Cited by 10 publications

References 42 publications

Neuroinflammatory response on a newly combinatorial cell–cell interaction chip

Neuroinflammatory response on a newly combinatorial cell–cell interaction chip

The Biological Implication of Semicarbazide-Sensitive Amine Oxidase (SSAO) Upregulation in Rat Systemic Inflammatory Response under Simulated Aerospace Environment

Radiation Effects on Brain Extracellular Matrix

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