The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo

Leite-Silva, Vânia Rodrigues; Lamer, Marina Le; Sanchez, Washington Y.; Liu, David C.; Morrow, Isabel C.; Martin, Darren J.; Silva, Heron D. T.; Prow, Tarl W.; Grice, Jeffrey E.; Roberts, Michael S.

doi:10.1016/j.ejpb.2013.01.020

Cited by 113 publications

(83 citation statements)

References 41 publications

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“…Only C5 showed higher values than the untreated control area, yet this difference was not statistically significant. Leite-Silva et al (2013) found a similar profile when evaluating skin hydration and transepidermal water loss of coated zinc oxide nanoparticles. Although the values were higher than the untreated area, the test formulations were not statistically significant.…”

Section: Evaluation Of In Vivo Efficacymentioning

confidence: 71%

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Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an alternative of natural moisturizer in cosmetic formulations

Damasceno¹,

Silva²,

Fernandes³

et al. 2016

Braz. J. Pharm. Sci.

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The aim of this work was the obtainment of Opuntia fícus-indica (L.) Mill extract for the development of cosmetic formulations and in vivo evaluation of its moisturizing effects. The formulations were tested for preliminary and accelerated stability. Organoleptic characteristics, pH values and rheological behavior were assessed. The evaluation of moisturizing efficacy of the emulsions formulated with 3.0% of Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7 containing 1.0 and 3.0% of O. ficus-indica hydroglycolic extract (EHG001) was performed using the capacitance method (Corneometer®) and the transepidermal water loss -TEWL evaluation (Tewameter®). The emulsions formulated were stable, exhibiting pseudoplastic and thixotropic behavior. The results of evaluation of moisturizing efficacy showed increased skin hydration after five hours by mainly increasing the skin barrier effect. The formulations containing 1.0 and 3.0% of EHG001 enhanced the skin barrier effect by reducing TEWL up to four hours after application. The results observed suggest that O. ficus-indica hydroglycolic extract may act through a humectant and occlusion mechanism.Uniterms Opuntia fícus indica/emulsion stability. Opuntia fícus indica/cosmetic efficacy. Skin/cosmetics/ use/efficacy

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Section: Evaluation Of In Vivo Efficacymentioning

confidence: 71%

“…and were therefore categorized as having dry skin (Leite-Silva et al, 2013;Courage-Khazaka, 2014). Table IV shows changes in skin hydration evaluated by the capacitance method on the Corneometer®.…”

Section: Evaluation Of In Vivo Efficacymentioning

confidence: 99%

Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an alternative of natural moisturizer in cosmetic formulations

Damasceno¹,

Silva²,

Fernandes³

et al. 2016

Braz. J. Pharm. Sci.

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show abstract

“…However, these composite materials are too hard for use on a human face, where softer materials are required for use as white pigments. In addition, one study has reported that microfine zinc oxide is adsorbed through the skin [4]. A novel white pigment that is not adsorbed must be used.…”

Section: Introductionmentioning

confidence: 99%

Influence of pH-control in phosphoric acid treatment of zinc oxide

Onoda

Chemel

2017

Cerâmica

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Zinc oxide is often used as a white pigment for cosmetics; however, it shows photocatalytic activity that causes decomposition of sebum on the skin when exposed to the ultraviolet radiation in sunlight. In this work, zinc oxide was reacted with phosphoric acid at various pH values to synthesize a novel white pigment for cosmetics. The chemical composition, powder properties, photocatalytic activities, colors, and smoothness of these pigments were studied. The obtained materials exhibited X-ray diffraction peaks relating to zinc oxide and phosphate after phosphoric acid treatment. The ratio of zinc phosphate to zinc oxide was estimated from inductively coupled plasma -atomic emission spectroscopy results. Samples treated at pH 4-7 yielded small particles with sub-micrometer sizes. The photocatalytic activity of zinc oxide became lower after phosphoric acid treatment. Samples treated at pH 4-7 showed the same reflectance as zinc oxide in both the ultraviolet and visible ranges. Adjustment of the pH was found to be important in the phosphoric acid treatment of zinc oxide. Keywords: zinc oxide, phosphoric acid treatment, photocatalytic activity, particle size. Resumo

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“…The clinical applications of in vivo label-free MPM span from skin cancer detection and diagnosis [1][2][3][4], to characterizing and understanding keratinocyte metabolism [5], skin aging [6,7], pigment biology [8][9][10], and cosmetic treatments [11][12][13]. MPM is based on laser-scanning microscopy, a technique that utilizes a focused laser beam that is raster-scanned across the sample to create high-resolution images.…”

Section: Introductionmentioning

confidence: 99%

Rapid mesoscale multiphoton microscopy of human skin

Balu

Mikami

Hou

et al. 2016

Biomed. Opt. Express

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We present a multiphoton microscope designed for mesoscale imaging of human skin. The system is based on two-photon excited fluorescence and second-harmonic generation, and images areas of ~0.8x0.8 mm 2 at speeds of 0.8 fps (800x800 pixels; 12 frame averages) for high signal-to-noise ratio, with lateral and axial resolutions of 0.5µm and 3.3µm, respectively. The main novelty of this instrument is the design of the scan head, which includes a fast galvanometric scanner, optimized relay optics, a beam expander and high NA objective lens. Computed aberrations in focus are below the Marechal criterion of 0.07λ rms for diffraction-limited performance. We demonstrate the practical utility of this microscope by ex-vivo imaging of wide areas in normal human skin. Sterry, and A. Patzelt, "In vivo methods for the analysis of the penetration of topically applied substances in and through the skin barrier," Int.

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The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo

Cited by 113 publications

References 41 publications

Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an alternative of natural moisturizer in cosmetic formulations

Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an alternative of natural moisturizer in cosmetic formulations

Influence of pH-control in phosphoric acid treatment of zinc oxide

Rapid mesoscale multiphoton microscopy of human skin

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