The effect of food and tablet formulation on plasma prednisolone levels following administration of enteric‐coated tablets.

Abstract

1 Plasma prednisolone levels have been compared following the administration of enteric‐coated prednisolone to fasted and non‐fasted subjects. The effect on plasma levels of altering the formulation of the enteric‐coating has also been studied. 2 The presence of food in the stomach at the time of administration does not affect the absorption of enteric‐coated prednisolone tablets. 3 There was considerable inter‐subject variation in plasma prednisolone levels after administration of shellac based enteric‐coated tablets. However, plasma levels were more consistent when a preparation whose formulation was based upon cellulose acetate phthalate (CAP) was given. 4 It is concluded that the pattern of absorption and plasma prednisolone levels depend on the formulation of the enteric coating. The bioavailability of the CAP based preparation is similar to that of plain prednisolone.

Concurrent administration of cimetidine and enteric‐coated prednisolone: effect on plasma levels of prednisolone.

“…A relatively large inter-individual variation in plasma prednisolone levels, as has been noted previously (Lee et al, 1979;Morrison et al, 1977), was present in this data. The effect of order of cimetidine administration on prednisolone AUC could be explained by the chance inclusion of three subjects who are relatively poor drug absorbers in the group receiving cimetidine second.…”

“…This implies adequate suppression of gastric acid secretion since the cimetidine concentration required to produce a 50% reduction of maximal histamine-induced acid output is 0.5 -I pg ml-' (Burland, Duncan, Hesselbo, Mills, Sharpe, Haggie & Wyllie, 1975). The plasma levels of prednisolone attained following the administration of 10 mg enteric-coated prednisolone are broadly comparable with previous data reported by ourselves (Morrison et al, 1977) and others (Lee et al, 1979). The half-life is also similar to that found in our previous work and was unaltered by cimetidine suggesting that no gross change in prednisolone disposition is produced by the latter drug.…”

“…We have, however, failed to demonstrate a clinically significant effect on the absorption of orally administered tetracycline (Fisher, House, Inns, Morrison, Rogers & Bradbrook, 1980). A preliminary report by Sternberg, King & Toskes (1978) has described inhibition of the absorption of Concurrent administration of food does not affect the absorption of enteric-coated prednisolone (Lee, Taylor, Walker & James, 1979). Similarly, food does not reduce cimetidine bioavailability (Bodemar, Norlander, Fransson & Walen, 1979).…”

An Overview on Sustained Release Enteric Coated Tablet of Pentoprazole

“…The coating material deposit has beenmeasured to obtain different weight gains such as 8%, 10% and 16% from its weight. The tablets are checked for the weight gain before and after the application of designated time of coating in order to verify the procurement of desired 32 .…”

The effect of concurrent administration of antacids on prednisolone absorption [letter]

“…Blood samples were taken through an indwelling cannula sited in a forearm vein, at the time that the tablets were administered and subsequently at 20 min intervals for 4 h and then hourly for 3 h. The subjects did not eat or drink for 2 h after the start of the test but were then permitted food and drink ad libitwn and were allowed to carry out their normal daily activities. Plasma prednisolone levels were measured by a radioimmunoassay technique which has been described elsewhere (Lee, Taylor, Walker & James, 1979). The samples were assayed using an antiserum to prednisolone which cross-reacted in vitro with cortisol (10%) and predhisone (5%).…”