The effect of fluoride on mineralization during tooth germ development in neonatal hamsters

Tros, G.H.J.; Lyaruu, D.M.; Vis, R.D.

doi:10.1016/0168-583x(90)90295-6

Cited by 4 publications

(2 citation statements)

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“…4a). The mineral content in these layers of aprismatic enamel can be up to 15 times that of control value areas, with increased calcium-tophosphate ratios, and a high fluoride content (Lyaruu et al, 1989bTros et al, 1990).…”

Section: Effects Of Fluoride On Enamel Crystal Growthmentioning

confidence: 99%

“…Parenteral Administration of Fluoride A single injection with a low (2 mg F/kg body weight) to high dose of fluoride (14 mg F/kg body weight) induces a characteristic double-response event in secretory enamel, consisting of an inner hyper-followed by an outer hypo-mineralized line (Kruger, 1967;Fejerskov et al, 1974;Neiman and Eisenmann, 1975;Shinoda, 1975;Tros et al, 1990;Lyaruu et al, 2006). The intensity of the double-response line is dose-dependent.…”

Section: Doses Of Fluoride That Cause Mineralization Defects In Develmentioning

confidence: 99%

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The Impact of Fluoride on Ameloblasts and the Mechanisms of Enamel Fluorosis

Lyaruu²,

2009

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Intake of excess amounts of fluoride during tooth development cause enamel fluorosis, a developmental disturbance that makes enamel more porous. In mild fluorosis, there are white opaque striations across the enamel surface, whereas in more severe cases, the porous regions increase in size, with enamel pitting, and secondary discoloration of the enamel surface. The effects of fluoride on enamel formation suggest that fluoride affects the enamelforming cells, the ameloblasts. Studies investigating the effects of fluoride on ameloblasts and the mechanisms of fluorosis are based on in vitro cultures as well as animal models. The use of these model systems requires a biologically relevant fluoride dose, and must be carefully interpreted in relation to human tooth formation. Based on these studies, we propose that fluoride can directly affect the ameloblasts, particularly at high fluoride levels, while at lower fluoride levels, the ameloblasts may respond to local effects of fluoride on the mineralizing matrix. A new working model is presented, focused on the assumption that fluoride increases the rate of mineral formation, resulting in a greater release of protons into the forming enamel matrix.

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Section: Effects Of Fluoride On Enamel Crystal Growthmentioning

confidence: 99%