Abstract:The Informative AbstractTo the Editor.\p=m-\The Informative Abstract1 contained information that was particularly worrisome to me as an editor responsible for the publication of a number of medical journals, namely your assertion that physicians "spend many hours each January reading journals."All previously available data about the reading habits of physicians indicate a fairly even (although low) annual distribution of reading time, punctuated by small decreases in July and September attributable to vacation… Show more
“…In 1992, Hacker and Rasmussen [11] first described the use of the 585 nm pulsed dye laser (PDL) for psoriasis. The PDL has been shown to be effective in a number of vascular lesions such as port-wine stains [12], and since vascularization is observed in the early onset of psoriasis, using the PDL to treat psoriasis seemed a logical alternative.…”
“…In 1992, Hacker and Rasmussen [11] first described the use of the 585 nm pulsed dye laser (PDL) for psoriasis. The PDL has been shown to be effective in a number of vascular lesions such as port-wine stains [12], and since vascularization is observed in the early onset of psoriasis, using the PDL to treat psoriasis seemed a logical alternative.…”
“…Interference with leukocyte trafficking via a selective destruction of the dilated capillaries may be an effective therapeutic intervention in psoriasis. Selective targeting of blood vessels may be achieved with the flash-lamp pumped pulsed dye laser (PDL) [3]. The effect of the PDL treatment is based on the selective absorption of short pulses of 585 nm light by oxy-hemoglobin inducing photothermolysis of capillaries leaving the other nearby structures in the skin undamaged [4].…”
The expression of epidermal activation markers and the dermal T cell infiltrates were decreased after both treatments. The decreased expression of VEGFR2 and VEGFR3 followed by the down-regulation of TNF-alpha and IL-23p19 may be contributory factors in the efficacy of PDL in stable plaque-type psoriasis.
“…Multiple previous studies have shown different results, ranging from complete remission to no improvement at all. [1][2][3][4][5][6][7] It is difficult to compare the results of these studies, because they all used different treatment modalities. The number of treatments varied from only one treatment up to five.…”
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