The effect of fibroids without cavity involvement on ART outcomes independent of ovarian age

Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation

“…The second study included a matched cohort analysis of women undergoing OD in whom adenomyosis had been diagnosed by TVS. Two control groups were established, one of patients who also had endometriosis, given the strong association between endometriosis and adenomyosis (4,19), and another of patients in whom ultrasonography did not reveal any pathology. Special care was taken to rule out cases of fibroids from all the groups.…”

“…Some authors believe that the two conditions represent different stages of the disease, whereas others identify them as separate entities (4,19). For this reason, the mechanisms leading to adenomyosis-associated infertility have been explained in similar physiopathological terms to those of endometriosis (20)(21)(22)(23)(24).…”

The uterus and fertility

“…Several studies suggest an adverse effect on clinical PR and IR in women undergoing IVF, particularly with large myomas (e.g., >4 cm) (108)(109)(110)(111)(112)(113)(114), whereas others fail to show such an association (115)(116)(117)(118)(119)(120). It must be noted that only one study was adequately powered to detect a difference in pregnancy rates (120). Given such conflicting results from retrospective, nonrandomized studies it is difficult to determine the effect of myomas that do not distort the uterine cavity on spontaneous pregnancy and IVF treatment associated pregnancy rates.…”

Pregnancy outcome after magnetic resonance–guided focused ultrasound surgery (MRgFUS) for conservative treatment of uterine fibroids

“…Uterine fibroids can impair fertility and cause specific pregnancy complications (3)(4)(5)(6)(7)(8)(9). However, the process of treating fibroids can also lead to morbidity and subsequent fertility impairment.…”