The effect of fermented soy (FSWW08) on blood hematology and cachexia in cancer patients

Abstract

In cancer patients, appetite and immune status are significantly weakened. Two experimental fermented formulations without (group A, named as FSWW08) and with (group B, FSWW08) an extract from yam root were investigated against a placebo formulation with casein (group C) in a clinical study conducted in six cancer hospitals where cancer patients underwent radio or chemotherapy (patients undergoing radiation therapy n=78, patients undergoing chemotherapy n=184, total 262). IgG and IgA were increased by formulation A in patients despite receiving radio- or chemotherapy. Group A experienced statistically significant increases in lymphocyte transformation rates, whereas group B and group C did not. Formulations A and B either inhibited or lessened statistically significant decreases in white blood counts, whereas the placebo group experienced substantial decreases. Hemoglobin and platelet decreases were inhibited in group A, although not statistically significantly. Patients in group A received no blood transfusions, whereas many patients from the placebo group received blood transfusions. Appetite loss was reduced in group A from 57.9% to 13.3% and in group B from 70% to 35.8%. In the placebo group, an increase in appetite loss was detected under chemo and radiation therapy from 41.8% to 70.9%.

Can Plants’ Ability for DNA Repair and Stress Defense be Used against Patients’ Circulating Tumor Cells?

“…The study protocol was reviewed by a local institutional review board (IRB) to protect the rights of patients, safety and well-being of humans involved in a clinical trial by reviewing all aspects of the trial and approving its startup and was published previously [24,39,40]. All patients had to sign an Informed Consent Form after the physician explained the study and he read the informed consent form where the study goal was outlined in a written form, in which the study was outlined and participation was voluntarily and it was explained individually to all patients that they could leave the study at any time even without explanation.…”

“…This paper therefore systematically investigates the effect of fermented soy bean formulation on cancer cells in vitro, as was shown by others also, in vivo in CTC extracted from blood from cancer patients, which has not been shown before. We detected and reported earlier that the effectiveness of chemotherapy was increased by fermented soy formulation, side effects were reduced, and survival increased [39,40]. This study investigates in vitro whether a combination of the classic cytotoxic compound doxorubicin may be combined with fermented soy bean and counterbalance some of the side effects of classical chemotherapy on the genetic level.…”

“…It is defined that DNA replication stress generates genomic instability and causes suppressed apoptosis [10][11][12][13][14][15][16][17][18][19][20][21]. Recently, researchers have suggested that dietary compounds such as curcumin, sulforaphana, soy Isoflavones, epigallocatechin-3-gallate, resveratrol, lycopene, piperine and vitamin D3 can directly or indirectly affect cancer stem cell self-renewal pathways [9], as well as reduce unfavorable cellular stress caused by chemotherapy and making chemotherapy more effective [23,24]. Plants have evolved to live in environments where they are often exposed to different stress factors in combination and are subject to high levels of DNA damage resulting from the plant's obligatory dependence on environmental stresses like solar UV radiation, attacks of yeasts to digest plants, drought, chilling injury, and other air and soil pollutants including heavy metals and metabolic by-products from endogenous processes [24].…”

“…Recently, researchers have suggested that dietary compounds such as curcumin, sulforaphana, soy Isoflavones, epigallocatechin-3-gallate, resveratrol, lycopene, piperine and vitamin D3 can directly or indirectly affect cancer stem cell self-renewal pathways [9], as well as reduce unfavorable cellular stress caused by chemotherapy and making chemotherapy more effective [23,24]. Plants have evolved to live in environments where they are often exposed to different stress factors in combination and are subject to high levels of DNA damage resulting from the plant's obligatory dependence on environmental stresses like solar UV radiation, attacks of yeasts to digest plants, drought, chilling injury, and other air and soil pollutants including heavy metals and metabolic by-products from endogenous processes [24]. Therefore, to survive under frequent and extreme environmental stress conditions, plant cells have evolved with highly efficient and wide-ranging mechanisms for the detection and repair of DNA damage to eliminate the chances of permanent genetic alterations and to maintain genome stability for faithful transfer of genetic information over generations [26][27][28].…”

Cancer protection of soy resembles cancer protection during pregnancy

“…cytokines ( Figures 10-13) (37). A clinical trial with breast cancer patients revealed a reduction of Th1 cytokines and a reduction of symptoms related to Th1 cytokines after consuming fermented soy ( Figure 14) (38,39). It is now recognized that cytokines in the blood of cancer patients are released from immune cells within the tumor, increasing the surrounding capillary membrane permeability, leading to the spread of tumor cells and cytokines, and causing metastasis and discomfort ( Figure 15) (40)(41)(42)(43)(44)(45)(46).…”