Cancer protection of soy resembles cancer protection during pregnancy

Abstract

It has been established that carrying a pregnancy to full-term at an early age can protect against contracting cancer by up to 50% in later life. The trophoblast theory of cancer states that trophoblast and cancer tissue are very similar. New findings suggest that the loss of fetal cells during pregnancy resemble those cells responsible for causing metastasis in cancer. Fetal cells and spreading cancer cells are highly proliferative. They are similar to stem cells, exhibiting no or low hormone receptor expression, and require a hormone receptor independent mechanism for control. Control of membrane stability during pregnancy is of vital importance for a successful pregnancy and is mediated by androstenediol and 2-methoxyestradiol. 2-Methoxyestradiol has no hormone receptor affinity and elicits strong anticancer effects particularly against cancer stem cells and fetal cells, for which currently no treatment has yet been established. There is a discussion whether pregnancy reduces cancer stem cells in the breast. Soy isoflavones are structurally similar to both hormones, and elicit strong anticancer effects and antiangiogenesis via inhibition of NF-κB, even in hormone receptor independent breast cancers seen in epidemiologic studies. The trophoblast theory of cancer could help to explain why soy baby nutrition formulas have no effect on baby physiology, other than the nutritional aspect, although soy elicits many effects on the adult immune system. To survive the immune system of the mother, the immune system of the fetus has to be separated; otherwise, the reduction of the immune system in the mother, a necessary feature for the blastocyst to grow, would immediately reduce the immunity for the fetus and endanger its survival. Similar to a fetus, newly born babies show immune insensitive to Th1 and Th2 cytokines, which are necessary and crucial for regulating the immune system of the mother, thus raising the risk of the baby of developing allergies and neurodermatitis. Gene expression studies in vitro as well as in circulating tumor cells from patients consuming a fermented soy product support the antiangiogenic as well as antiproliferative effects of soy.

The effect of fermented soy (FSWW08) on blood hematology and cachexia in cancer patients

“…was diagnosed as cancer-free 11-h surgery: colon conduit is performed (and elimination of nephrostomy). After surgery, no wound healing problems were detected Tissue samples show no cancer cells Patient was still under FSWW08 nutrition Th1-cytokine formation [16] . Therefore, the improvement of blood hematology and cachexia may very well be related to improvement in cancer treatment.…”

“…In light of interesting findings from animal studies [10] and human studies [9,15,16] , a study was initiated to investigate whether a soy product, FSWW08, would increase hematopoiesis and increase appetite in cancer patients.…”

“…Reduction of cachexia in cancer patients may be caused by cytokine formation of cancer stem cells in cancer tissue (Figure 1) [6] . This, however, is mediated by a decrease in NF-κ B activity of tumor cells [9,15,16] .…”

“…A specially fermented soy formulation, named FSWW08, increased body weight and appetite in several pilot trials [15,16] and prolonged the survival of treatment-resistant cancer patients [15] . Therefore, a human study with a larger cohort of patients was designed to investigate the effect of two experimental fermented soy isoflavone formulations on symptoms of cachexia and leukocytopenia against a placebo formulation during chemotherapy and radiation therapy.…”

Balancing steroidal hormone cascade in treatment-resistant veteran soldiers with PTSD using a fermented soy product (FSWW08): a pilot study

“…On the contrary, soy baby nutrition formulation has no effect on the immune system of babies, which have similar isofl avone doses as FSWW08, when compared with a person with a body weight of 80 kg (about 500 -900 mg isofl avones) [69,70] . It was suggested that the immune system of a newborn is not fully developed [20] . Production of DHEA by the adrenal reticularis is a species-specifi c phenomenon; rodents have little circulating DHEA and the pattern of DHEA secretion differs between human and non-human primates [71] .…”