The Effect of Familial Sinistrality on the Relation between Schizophrenialike Thinking and Pseudoneglect

Kalaycioğlu, Canan; Nalçacı, Erhan; Budanur, Ömür Ece; Genç, Yasemin; Çíçek, Metehan

doi:10.1006/brcg.2000.1217

Cited by 21 publications

(17 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IntAn scores were unrelated to hemispatial biases in either task. Thus, we observed SBRs for positive schizotypy that were not simply nonsignificant (Gooding & Braun, 2004), but opposite to those reported in previous studies that tested similar sample sizes (Brugger & Graves, 1997;Kalaycioglu et al, 2000;Mohr, Bracha, & Brugger, 2003;Taylor et al, 2002). Jewell and McCourt (2000) reviewed several variables (e.g., age, handedness, performing hand, or sex) that modulate the degree and direction of pseudoneglect in line bisection performance in the normal population.…”

Section: Discussioncontrasting

confidence: 99%

“…This latter observation is in line with independent reports on such leftward SBR when assessing line bisection performance (Brugger & Graves, 1997;Kalaycioglu et al, 2000;Mohr, Bracha, & Brugger, 2003;Taylor et al, 2002) and side preferences in facial decision tasks (Leonards, Jones, & Mohr, 2005;Luh & Gooding, 1999). In analogy to the findings from patients with schizophrenia (Bracha, 1989;Bracha et al, 1993;Harvey, Nelson, Haller, & Early, 1993;Tomer & Flor-Henry, 1989), it could be suggested that schizotypy of the positive type may be associated with a relatively hyperactive right-hemispheric DA system.…”

Section: Introductionsupporting

confidence: 80%

See 1 more Smart Citation

Schizotypy and pseudoneglect: A critical update on theories of hemispheric asymmetries

Liouta

Smith

Möhr

2008

Cognitive Neuropsychiatry

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionsupporting

confidence: 80%

Schizotypy and pseudoneglect: A critical update on theories of hemispheric asymmetries

Liouta

Smith

Möhr

2008

Cognitive Neuropsychiatry

View full text Add to dashboard Cite

show abstract

“…For instance, right hemispatial inattention, a neurocognitive deficit frequently observed in schizophrenia, was associated with schizophrenia-like experience and beliefs in healthy young male students. [7][8][9] In these studies, the magical ideation scale was used to assess quantitatively a person's proneness to schizophrenia-like experience and thoughts (positive dimension of schizotypy). 10 Therefore, the continuum of magical ideation is psychometrically relevant even for completely healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

Sleep Spindles Are Related to Schizotypal Personality Traits and Thalamic Glutamine/Glutamate in Healthy Subjects

Lustenberger

O’Gorman

Pugin

et al. 2014

Schizophrenia Bulletin

View full text Add to dashboard Cite

Background: Schizophrenia is a severe mental disorder affecting approximately 1% of the worldwide population. Yet, schizophrenia-like experiences (schizotypy) are very common in the healthy population, indicating a continuum between normal mental functioning and the psychosis found in schizophrenic patients. A continuum between schizotypy and schizophrenia would be supported if they share the same neurobiological origin. Two such neurobiological markers of schizophrenia are: (1) a reduction of sleep spindles (12-15 Hz oscillations during nonrapid eye movement sleep), likely reflecting deficits in thalamocortical circuits and (2) increased glutamine and glutamate (Glx) levels in the thalamus. Thus, this study aimed to investigate whether sleep spindles and Glx levels are related to schizotypal personality traits in healthy subjects. Methods: Twenty young male subjects underwent 2 all-night sleep electroencephalography recordings (128 electrodes). Sleep spindles were detected automatically. After those 2 nights, thalamic Glx levels were measured by magnetic resonance spectroscopy. Subjects completed a magical ideation scale to assess schizotypy. Results: Sleep spindle density was negatively correlated with magical ideation (r = −.64, P < .01) and thalamic Glx levels (r = −.70, P < .005). No correlation was found between Glx levels in the thalamus and magical ideation (r = .12, P > .1). Conclusions: The common relationship of sleep spindle density with schizotypy and thalamic Glx levels indicates a neurobiological overlap between nonclinical schizotypy and schizophrenia. Thus, sleep spindle density and magical ideation may reflect the anatomy and efficiency of the thalamo-cortical system that shows pronounced impairment in patients with schizophrenia.

show abstract

“…The idea of a relationship between schizotypy and overt clinical psychosis is supported by studies that found that highly schizotypal subjects reveal cognitive (Gooding et (Klein et al 1999; Pizzagalli et al 2000) peculiarities comparable to those described for patients with schizophrenia. However, neuropsychological similarities between schizotypy and schizophrenia are not limited to highly schizotypal subjects, but can also be observed in random samples of participants (Kalaycioglu et al 2000; Brugger and Graves 1997; Mohr et al 2003a; Taylor et al 2002), for whom schizotypal features are quantitatively less prominent yet qualitatively equivalent.…”

Section: Introductionmentioning

confidence: 99%

Levodopa reverses gait asymmetries related to anhedonia and magical ideation

Möhr

Landis

Bracha

et al. 2004

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

■ Abstract Animals and men turn preferentially away from the hemisphere with the more active dopamine (DA) system. Consistent with the idea of a right-hemispheric hyperdopaminergia in schizophrenia, a leftsided turning bias was described for unmedicated psychotic patients. We investigated the modulating role of DA and schizophrenia-like thought on whole-body turns in a controlled double-blind study. The number of veers to either side when walking blindfolded straight ahead (20 meter) was assessed in 40 healthy righthanded men (20 men received levodopa, the remaining participants placebo). Side preferences were analyzed in terms of individuals' positive (Magical Ideation, MI) and negative (Physical Anhedonia, PhysAn) schizotypal features. In the placebo group, increasing MI scores were related to increasing left-sided veering and increasing PhysAn scores were related to increasing right-sided veering. In the levodopa group, this relationship between preferred veering side and type of schizotypy was reversed. The finding in the placebo group suggests an association between MI and a relative right-hemispheric hyperdopaminergia. Unexpectedly, levodopa did not enhance this veering bias, but reversed it, suggesting that psychosis-protective mechanisms exist in the healthy positive "schizotypic" brain. Also unexpectedly, levodopa made "anhedonics" veer like "magics" after placebo, suggesting that DA agonists suppress negative schizotypal symptoms.

show abstract

The Effect of Familial Sinistrality on the Relation between Schizophrenialike Thinking and Pseudoneglect

Cited by 21 publications

References 41 publications

Schizotypy and pseudoneglect: A critical update on theories of hemispheric asymmetries

Schizotypy and pseudoneglect: A critical update on theories of hemispheric asymmetries

Sleep Spindles Are Related to Schizotypal Personality Traits and Thalamic Glutamine/Glutamate in Healthy Subjects

Levodopa reverses gait asymmetries related to anhedonia and magical ideation

Contact Info

Product

Resources

About