The effect of exogenous melatonin on stimulated neurohypophysial hormone release in man

Forsling, Mary L.; Williams, Adrian

doi:10.1046/j.1365-2265.2002.01644.x

Cited by 8 publications

(6 citation statements)

References 23 publications

(29 reference statements)

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“…pophysial hormone AVP and OXT release in human subjects (Forsling et al, 1999;Forsling and Williams, 2002). Our observation of a strong MT1 receptor expression and a colocalization with AVP and with OXT in the SON and PVN suggests that the nocturnally increased levels of melatonin can act as a direct circadian message to regulate the neuroendocrine activity of the SON and PVN, thus contributing to the diurnal pattern of vasopressin and OXT levels and kidney function, without the need of a direct innervation of the SCN to the neuroendocrine cells.…”

Section: Mt1 In the Pvn And Son And Colocalization With Avp Oxt Andmentioning

confidence: 79%

“…Melatonin was shown to regulate vasopressin (AVP) and oxytocin (OXT) release in the hypothalamus in vitro (Yasin et al, 1993), in vivo in rats (reviewed in Juszczak, 2001), and in healthy human subjects (Forsling et al, 1999;Forsling and Williams, 2002). In order to explore whether melatonin may exert such an effect directly via the presence of the MT1 receptor in the hypothalamic AVP and OXT neurons, colocalization studies of the MT1 receptor with AVP and with OXT in the hypothalamus were performed.…”

mentioning

confidence: 99%

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Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin‐releasing hormone

Zhou

Balesar

et al. 2006

J of Comparative Neurology

148

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Melatonin is implicated in numerous physiological processes, including circadian rhythms, stress, and reproduction, many of which are mediated by the hypothalamus and pituitary. The physiological actions of melatonin are mainly mediated by melatonin receptors. We here describe the distribution of the melatonin receptor MT1 in the human hypothalamus and pituitary by immunocytochemistry. MT1 immunoreactivity showed a widespread pattern in the hypothalamus. In addition to the area of the suprachiasmatic nucleus (SCN), a number of novel sites, including the paraventricular nucleus (PVN), periventricular nucleus, supraoptic nucleus (SON), sexually dimorphic nucleus, the diagonal band of Broca, the nucleus basalis of Meynert, infundibular nucleus, ventromedial and dorsomedial nucleus, tuberomamillary nucleus, mamillary body, and paraventricular thalamic nucleus were observed to have neuronal MT1 receptor expression. No staining was observed in the nucleus tuberalis lateralis and bed nucleus of the stria terminalis. The MT1 receptor was colocalized with some vasopressin (AVP) neurons in the SCN, colocalized with some parvocellular and magnocellular AVP and oxytocine (OXT) neurons in the PVN and SON, and colocalized with some parvocellular corticotropin-releasing hormone (CRH) neurons in the PVN. In the pituitary, strong MT1 expression was observed in the pars tuberalis, while a weak staining was found in the posterior and anterior pituitary. These findings provide a neurobiological basis for the participation of melatonin in the regulation of various hypothalamic and pituitary functions. The colocalization of MT1 and CRH suggests that melatonin might directly modulate the hypothalamus-pituitary-adrenal axis in the PVN, which may have implications for stress conditions such as depression.

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Section: Mt1 In the Pvn And Son And Colocalization With Avp Oxt Andmentioning

confidence: 79%

mentioning

confidence: 99%

Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin‐releasing hormone

Zhou

Balesar

et al. 2006

J of Comparative Neurology

148

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“…A number of studies in humans are compatible with those in rats suggesting GPCR action in the PVN. For example, peripheral melatonin modulates the VP response to exercise and hypertonic saline infusion [86] , while naloxone (a μ-opioid receptor blocker) enhances the plasma ACTH response to CRF [56] . In non-human primates, the odd study has investigated the effects of intranasal [250] and central [296] administration of GPCR ligands on PVN-based activity.…”

Section: Discussionmentioning

confidence: 99%

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis

Hazell

Hindmarch

Pope

et al. 2012

Frontiers in Neuroendocrinology

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Graphical abstractHighlights► The paraventricular and supraoptic nuclei of the hypothalamus are regulators of homeostasis. ► Over one hundred G protein-coupled receptors are expressed in each of these nuclei. ► The receptors have many functions including modulating neuropeptide synthesis and release. ► 20–30% of the receptors are ‘orphans’ whose endogenous ligand and function is unknown.

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“…In-house quality-control samples had a mean of 81 and 120 pg/ml, and a low and high quality-control pools betweenassay coefficient of variation of 15 and 20%, respectively. The cross-reactivity of Lys 8 -vasopressin, Arg 8 -vasopressin, met-enkephalin, vasoactive intestinal peptide, somatostatin, Ser 4 ,Ile 8 -oxytocin and ␣-atrial natriuretic peptide in the oxytocin assay is Ͻ0.02%. Other biochemical measurements were obtained using standard techniques.…”

Section: Study Participantsmentioning

confidence: 97%

“…Produced in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus, oxytocin enters the peripheral circulation through the posterior pituitary gland (9). While classically known for its role in parturition, lactation, and social behavior, both rodent (12,19,28) and human (8,22,29) data also suggest oxytocin has a role in regulating sodium homeostasis through fluid shifts; however, human data are limited, and results obtained are inconsistent (8,22,29).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin response to controlled dietary sodium and angiotensin II among healthy individuals

Srinivasa

Aulinas

O’Malley

et al. 2018

American Journal of Physiology-Endocrinology and Metabolism

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Oxytocin, while classically known for its role in parturition, lactation, and social behavior, also has been implicated in the control of sodium homeostasis in animal models. To improve our understanding of oxytocin physiology in humans, we measured basal oxytocin levels under low- and liberal-dietary-sodium conditions and following a peripheral angiotensin II (ANG II) infusion. Ten healthy individuals underwent a 6-day standardized low-sodium diet and a 6-day liberal-sodium diet. Each diet was followed by a graded ANG II infusion for 30-min sequential intervals at doses of 0.3, 1.0, and 3.0 ng·kg·min. Fasting serum oxytocin was assessed before and after ANG II infusion. Basal oxytocin levels (1,498.5 ± 94.7 vs. 1,663.3 ± 213.9 pg/ml, P = 0.51) did not differ after the low- and liberal-sodium diets. Following the ANG II infusion, ANG II levels and mean arterial pressure significantly increased as expected. In contrast, the ANG II infusion significantly lowered oxytocin levels from 1,498.5 ± 94.7 vs. 1,151.7 ± 118.1 pg/ml ( P < 0.001) on the low-sodium diet and from 1,663.3 ± 213.9 vs. 1,095.2 ± 87.4 pg/ml ( P = 0.03) on the liberal-sodium diet. The percent change in oxytocin following the ANG II infusion did not differ by sodium diet (-25 ± 5% vs. -28 ± 7% low- vs. liberal-sodium conditions, P > 0.99). Dietary sodium intake did not affect circulating oxytocin levels among healthy individuals. Systemic oxytocin levels were significantly suppressed following a peripheral ANG II infusion independent of dietary sodium conditions.

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The effect of exogenous melatonin on stimulated neurohypophysial hormone release in man

Abstract: Melatonin modulates the neurohypophysial response to different stimuli, low doses enhancing the response. This effect could contribute to the night-time increase in circulating concentrations of the hormones.

Cited by 8 publications

References 23 publications

Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin‐releasing hormone

Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin‐releasing hormone

G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis

Oxytocin response to controlled dietary sodium and angiotensin II among healthy individuals

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