2012
DOI: 10.1016/j.yfrne.2011.07.002
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Abstract: Graphical abstractHighlights► The paraventricular and supraoptic nuclei of the hypothalamus are regulators of homeostasis. ► Over one hundred G protein-coupled receptors are expressed in each of these nuclei. ► The receptors have many functions including modulating neuropeptide synthesis and release. ► 20–30% of the receptors are ‘orphans’ whose endogenous ligand and function is unknown.

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Cited by 68 publications
(64 citation statements)
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References 372 publications
(322 reference statements)
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“…G-protein-coupled receptors are expressed in the PVN and SON and have a major role eliciting rapid intracellular responses to regulate cell function. 12 It has been demonstrated that purine nucleotide depletion can lead to the manifestations of the disorders caused by PRPS1 loss-offunction mutations. In lieu of neuronal tissue, erythrocytes provide a good model for brain cells.…”
Section: Discussionmentioning
confidence: 99%
“…G-protein-coupled receptors are expressed in the PVN and SON and have a major role eliciting rapid intracellular responses to regulate cell function. 12 It has been demonstrated that purine nucleotide depletion can lead to the manifestations of the disorders caused by PRPS1 loss-offunction mutations. In lieu of neuronal tissue, erythrocytes provide a good model for brain cells.…”
Section: Discussionmentioning
confidence: 99%
“…The actions of neuropeptides on GPCRs can also be modulated at the receptor or effector level; for instance, members of the RGS (regulator of G-protein signaling) family of proteins can accelerate activation or deactivation of G-proteins, and may alter receptor-effector coupling (Chuang et al, 1998; Doupnik et al, 2004; Labouebe et al, 2007; Xie and Martemyanov, 2011). The literature on GPCRs is too voluminous to examine here, but has been addressed in some recent reviews (Rosenbaum et al, 2009; Hazell et al, 2012). …”
Section: G-protein Coupled Receptorsmentioning
confidence: 99%
“…These inconsistencies warrant further investigation. In addition to its effects on the NST, administration of OEA stimulates c-Fos transcription in magnocellular neurons of the paraventricular and supraoptic nuclei of the hypothalamus (28), two structures that are intimately involved in feeding and energy homeostasis (114,115). In the same neurons, OEA also enhances expression of the neuropeptide oxytocin, and injections of the oxytocin receptor antagonist L-368,899 into the cerebral ventricles impair the ability of systemic OEA injections to reduce food intake (116,117).…”
Section: Lipid-derived Signals Of Satietymentioning
confidence: 99%