The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

Self Cite

There is a progressive trend in the current literature in understanding the central effects of oxytocin, which besides its classical roles in parturition and lactation, seems to exert some facilitatory effects in most of the neuropsychiatric disorders. Thus, it seems that oxytocin is mainly linked to the neuropsychiatric disorders where the social component is more or less affected and it has also strong correlations with the stress-related mechanisms and hypothalamic-pituitary-adrenal (HPA) axis. In addition, the connections between oxytocin and the digestive system were previously suggested, including by some of our preliminary results, in the context of irritable bowel syndrome (IBS) pathology. Also, the relations between depression and stress in the context of cortisol implications are quite well described, although various modifications of cortisol (increased, decreased or nonmodified) were described in the major depression pathology. Thus, by using two research cohorts: one with major depression disorder (n = 15) and another one having both diagnosis of major depression disorder and irritable bowel syndrome in the same time (n = 15), we are showing in this report significantly increased levels of cortisol in patients with MDD and IBS, when compared with patients with MDD without IBS, while an opposite pattern was obtained by measuring the plasma level of oxytocin, where the patients with MDD and IBS had a significantly decreased concentration of oxytocin, as compared with those with MDD but without IBS.

mentioning

confidence: 99%

The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome

Hrițcu¹,

Dumitru²,

Pădurariu³

et al. 2020

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“…In addition, our result reported here can mecanistically relate to the nociceptive processes, since oxytocin is a widely accepted analgesic [5,18,19], although there is a clear lack of evidences on the clear mechanisms explaining the nociceptive effects of oxytocin [12].…”

Section: Resultsmentioning

confidence: 72%

“…Lately there is an increased awareness on the possible relevance of oxytocin as an important mediator in several psychiatric disorders including anxiety, autism, schizophrenia and depression as our group extensively reviewed or demonstrated lately [1][2][3][4][5][6][7].…”

mentioning

confidence: 99%

Preliminary Study on the Correlations Between Oxytocin Levels and Irritable Bowel Syndrome in Patients with Depression

Gavril¹,

Hrițcu²,

Pădurariu³

et al. 2019

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Lately there are increased evidences that oxytocin may be an important mediator in several psychiatric disorders including depression and anxiety. Oxytocin system seems to be linked with several neurotransmitters important in psychiatric disorder, but also with the hypothalamic�pituitary�adrenal (HPA) axis and is also a key factor in stress regulation mechanisms. Considering the oxytocin receptor pattern of distribution both central and peripherally and the growing data concerning the disbalance of oxytocin in psychiatric disorders we may speculate that oxytocin system may be at the core of psychosomatic disturbances. Also, recent data brought to attention that oxytocin receptor is distributed throughout gastrointestinal tract. Our hypothesis of the present study was that oxytocin system is disbalanced in irritable bowel syndrome considering also the psychological component of this digestive disorder. We preliminary report here a significant decrease of serum oxytocin levels in patients with major depression disorder and irritable bowel syndrome, as compared with those with major depression disorder alone.

“…as some kind of anti-stress molecule), since it can modulate neuroendocrine axes and adjusting the cortisol levels especially under stressful conditions [30]. There are also important correlations to be mentioned here between cortisol levels and the anxiety-related states [31], since our group also showed some protective effects of oxytocin in anxietyrelated behaviour and a variety of associated neuropsychiatric manifestations [32][33][34][35][36][37][38].…”

Section: Resultsmentioning

confidence: 87%

Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome

Hrițcu¹,

Pădurariu²,

Ciobîcă³

et al. 2019

Self Cite

The correlations between depression and stress are quite accepted nowadays, as well as the fact that cortisol levels could also represent fundamental risk factors for major depressive disorder. However, when it comes to the modifications of cortisol levels in depression, the results are controversial. Same goes for the cortisol modifications in irritable bowel syndrome (IBS), which is a functional digestive disorder characterized by a strong biopsychological component, being highly influenced or exacerbated by stressful stimuli. Thus, in the present report we were interested in seeing if there are any serum cortisol levels variations in patients with depression and irritable bowel syndrome, by looking at cortisol modifications in two different groups of patients: a control group with major depression disorder and another study group composed by major depression disorder + IBS patients. Thus, our data presented here are suggesting that there is a significant increase in cortisol levels in the morning serum of the patients with major depression disorder + IBS, as compared to the group having only depression. The results presented here could have an important relevance in the context of managing the stress-related factors in the pathological entities described above.