The effect of exercise on haematocrit, plasma volume and viscosity in diabetes mellitus

Abstract

Summary. Haematocrit, plasma volume and viscosity were not notably different at rest in fifteen diabetics from those in ten controls. After moderate exercise, plasma volume was reduced and haematoerit was increased significantly more than those in controls. In the diabetic subgroups based on varying degrees of dermal angiopathy, no significant differences were demonstrated. In circulatory steady state during exercise the diabetics responded with a marked increase of systolic blood pressure. The amount of filtrate from the vascular bed to the interstitial tissues was not correlated to increasing systolic pressure. The difference in work intensity between the groups is not of such an order that it can be assumed to influence haematoerit or plasma volume. These findings may indicate increasing" permeability of the capillary walls because of changes characteristic of diabetic microangiopathy. Effet de l'exercice sur l'hdmatocrite, ~e volume plasmatique et la viscositd clans le dgab~te sucrdRdsumd. L'h6matocrite, le volume plasmatique et la viseosit6 ehez 15 diab4tiques n'4taient pas notablement diff4rents au repos par rapport aux dix t4moins. Apr@s un exereiee mod4r6, le volume plasmatique diminuait et l'h@matoerite augmentait significativement plus que ehez les t4moins. Darts les sous-groupes diab4tiques, bas4s sur les degrgs variables d'angiopathie dermique, on n'a pas d4montr4 de diff6renees signifieatives. Darts des conditions eireulatoires stables, pendant l'exereiee, les diab4tiques r4pondaient par une augmentation marqu4e de la pression systolique du sang. La quantit@ de filtrat du lit vaseulaire aux tissus interstitiels n'4tait pas en eorr41ation avee la pression systolique accrue. La diff@renee darts l'intensit4 du travail entre les groupes n'est pas telle qu'elle puisse influeneer l'h6matoerite ou le volume plasmatique. Ces d6eouvertes peuvent indiquer une perm6abilit6 accrue des parois eapillaires k cause des modifications earaet6ristiques de la microangiopathie diab6tique.

Disturbance of Serum Viscosity in Diabetes Mellitus

“…The elevation observed in this study is comparable to the increased serum viscosity observed by Cogan et al (1) and the plasma viscosity increase reported by Isogai et al (5). Other studies have not demonstrated as large an increase (8)(9)(10)(11). A possible explanation for this disagreement may be developed by integrating observations from this study with three previously reported phenomena.…”

“…The increased protein level is the result of loss of plasma volume during standing and exercise. The plasma volume decreases more rapidly in diabetes in these circumstances (9). In contrast to the elevated serum protein levels found in ambulatory outpatient diabetics in this study (Table III), hospitalized diabetics have depressed serum protein levels (27).…”

“…The means differed by 4%. When the viscosity values were segregated by specific sequelae, the following mean values were found: retinopathy 1.280 cP [10], neuropathy 1.277 cP [10], and nephropathy 1.278 cP [9]. The excess of number of observations (in brackets) over total diabetics with sequelae is due to the presence of multiple sequelae in nine diabetics.…”

“…Less conclusive studies suggesting blood viscosity disturbance have also been reported (6, 7) and studies describing a total lack of change (8,9) or decrease (10) in plasma, serum, and blood viscosity have appeared.…”

Blood viscosity, lipid profile, and lipid peroxidation in type-1 diabetic patients with good and poor glycemic control

“…[28],[29],[30] As the osmolarity of the blood increases due to increased sugar level, the capillary permeability increases, thus increasing hematocrit and subsequently the blood viscosity. [31] Similar findings have been observed by Lowe et al [32] and Langer et al [33] that osmotic diuresis is caused by hyperglycemia, leading to decreaaed plasma volume and increased hematocrit. Barnes et al [34] reported that both hematocrit and blood viscosity decreased after institution of good diabetic control.…”