The effect of ethanol extract of myrmecodia pendens to tgf-β1 expression and osteoblast cells after tooth extraction (the experimental research on cavia cobaya)

Ismardianita, Efa; Nasrul, Ellyza; Yanwirasti, Yanwirasti; Satari, Mieke Hemiawati

doi:10.15562/jdmfs.v2i3.608

Cited by 3 publications

(5 citation statements)

References 5 publications

(5 reference statements)

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“…This decrease in collagen thickness occurs because collagen fibers begin to be replaced with bone matrix. 14 The results in Table 3 are in line with previous studies, which said that there was a rapid increase in the level of collagen thickness until the 21 st day, and the thickness would continue to decrease until the 90 th day. 14,29 The value in the control group was not too high because this group did not get any medication to support the healing process.…”

Section: Discussionsupporting

confidence: 89%

“…14 The results in Table 3 are in line with previous studies, which said that there was a rapid increase in the level of collagen thickness until the 21 st day, and the thickness would continue to decrease until the 90 th day. 14,29 The value in the control group was not too high because this group did not get any medication to support the healing process. However, it remained a normal inflammatory phase, resulting in low collagen stimulation.…”

Section: Discussionsupporting

confidence: 89%

“…This is in line with previous research, which said that the thickness of collagen would continue to increase from the 3 rd day after tooth extraction to the 14 th day with a denser collagen image. 28,14 However, collagen thickness decreased on the 28 th day in each group. This decrease in collagen thickness occurs because collagen fibers begin to be replaced with bone matrix.…”

Section: Discussionmentioning

confidence: 88%

“…Similarly, collagen also seems to decrease after the 14 th day and will continue to decrease until the 28 th day. 14,15 Histological analysis can be used as an option for examining a tissue. 16 This method can be used to observe bone microarchitecture, showing the mineral components, bone cells, and physiological processes of bone formation and resorption.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Application Bovine Amniotic Membrane on Osteoblasts, Osteocytes, and Collagen

Wibowo,

Octarina,

Munadziroh

et al. 2023

Padjadjaran J Dent

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Introduction: Tooth extraction can result in loss of alveolar bone. The application of biomaterials Bovine Amniotic Membrane (BAM) that containing growth factors and collagen is expected to play a role in socket preservation. This study aimed to observe the effect of BAM application on the growth of osteoblasts, osteocytes, and collagen in histological preparate of the alveolar bone socket of Sprague Dawley rats (SD). Methods: 16 male SD rats were used in this group. SD rats were extracted on the mandible central incisivus. Afterward, it was divided into two groups, specifically the control group (without treatment) and the treatment group (BAM application). After extraction, the treatment group was applied with BAM with a size of 1.5 mm x 10 mm in socket alveolar bone. On the 14th and 28th day, the rats were euthanized and the alveolar bone socket of mandibular tissue was taken and stained with Hematoxylin Eosin (HE) and Masson Trichrome (MT). Results: The results of all groups showed that the number of osteoblasts and collagen thickness was higher on day 14th compared to day 28th, while osteocytes continued to increase from day 14th to 28th. The thickness of collagen, osteoblasts, and osteocytes in groups with BAM application was higher than without application. Statistical results showed that there were significant differences between groups (p<0.05). Conclusion: The application of BAM can act as material preservation socket. This biomaterial can accelerate recovery by increasing collagen thickness, osteoblasts, and osteocytes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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The Effect of Application Bovine Amniotic Membrane on Osteoblasts, Osteocytes, and Collagen

Wibowo,

Octarina,

Munadziroh

et al. 2023

Padjadjaran J Dent

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“…Flavonoid can manage cell function by stimulating TGF-β production, whereas TGF-β induces proliferation and migration of osteoblast. 19 The increase of osteoblastic proliferation and activation may increase the amount of osteoblast, which further increase the expression of osteoprotegerin (OPG). 4 An increase of OPG is very influential to the osteoclast activation, since OPG is the decoy receptor for Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL), by inhibiting the interaction between RANKL and Receptor Activator of Nuclear Factor Kappa-B (RANK) in precursor osteoclast cell membrane, thus inhibit the osteoclastogenesis.…”

Section: Discussionmentioning

confidence: 99%

Changes in osteoblast and osteoclast cell count after moringa oleifera leaf extract administration during orthodontic tooth movement

Syarif

Kusumaningsih

Arundina

2020

J Dentomaxillofac Sci

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Objective: The aim of this study was to analyze the effect of moringa leaf extract administration at 5%, 10%, and 20% concentration toward osteoblast and osteoclast cell count in tension area of Cavia cobaya tooth movement. Material and Methods: This study was an experimental research with post test only control group design conducted on Cavia Cobaya. The samples were divided into four groups, namely control group (given orthodontic forces), P1 group (given orthodontic forces and moringa oleifera extract at 5% concentration), P2 group (given orthodontic forces and moringa oleifera extract at 10% concentration) and P3 group (given orthodontic forces and moringa oleifera extract at 20% concentration). The samples were sacrificed in day 15 and the tissue were collected for histological test to examine osteoblast and osteoclast cell count. Results: The Anova test showed a significant difference of osteoblast and osteoclast cell count among groups (p<0.05). Conclusion: Moringa leaves extract administration at 20% concentration for seven days shows higher number of osteoblast and lower number of osteoclast compared to control group, 5% and 10% extract group.

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Wound Healing Activity of Binahong Leaf Extract Nanogel on Oral Tissues

HANAFIAH,

SATRIA,

HARAHAP

et al. 2024

Int J App Pharm

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Objective: The objective of the present study is to formulate and evaluate a topical gel containing minoxidil and tofacitinib citrate for alopecia areata. Methods: Forty-eight rat males were given treatment using 3% binahong leaf extract nanogel (twelve rats given palatal wound, twelve rats mandibular tooth extraction) and nanogel base (same with the amount used to extract). On palatal wounds, as many as four rats were in euthanasia on days third, seven, and fourteen for each group treatment. Whereas on the extraction groups, four rats were in euthanasia on days seventh, fourteen, and twenty-eight. palatal tissue and alveolar bone were taken, and fibroblasts as well as osteoblasts were observed using the coloring Hematoxylin-eosin. Results: Data revealed there were significant differences in the number of fibroblasts in each treatment between day three and seven (p<0.05), between day seven and fourteen (p<0.05), and there were significant differences in the number of osteoblasts in each treatment for 3 periods (p<0.05). Conclusion: Application of binahong leaf extract nanogel on palatal wound increased fibroblast proliferation and on post-extraction socket increased the number osteoblasts indicating better wound healing compared to control.

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The effect of ethanol extract of myrmecodia pendens to tgf-β1 expression and osteoblast cells after tooth extraction (the experimental research on cavia cobaya)

Cited by 3 publications

References 5 publications

The Effect of Application Bovine Amniotic Membrane on Osteoblasts, Osteocytes, and Collagen

The Effect of Application Bovine Amniotic Membrane on Osteoblasts, Osteocytes, and Collagen

Changes in osteoblast and osteoclast cell count after moringa oleifera leaf extract administration during orthodontic tooth movement

Wound Healing Activity of Binahong Leaf Extract Nanogel on Oral Tissues

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