The effect of ethanol, beer, and wine on histamine release from the dog stomach

Intorre, Luigi; Bertini, S; Luchetti, Elena; Mengozzi, G; Crema, Francesca; Soldani, Giulio

doi:10.1016/s0741-8329(96)00063-8

Cited by 13 publications

(13 citation statements)

References 17 publications

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“… 15 Similarly, Intorre et al . 3 reported that 4.8% pure ethanol had no effect on the plasma gastrin levels of anaesthetized dogs. We also confirmed that although the oral administration of 5% ethanol significantly stimulated gastric acid secretion, it had no effect on the plasma gastrin level.…”

Section: Discussionmentioning

confidence: 97%

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Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Matsuno

Sasaki

Okabe

2000

Aliment Pharmacol Ther

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Aim: To examine the effects of beer, ethanol, peptone meal and combinations of either peptone meal and beer or peptone meal and ethanol on gastric acid secretion in vagally denervated pouch dogs. Methods and Results: The oral administration of either 200 mL of beer, 5% ethanol or 10% peptone meal signi®cantly stimulated gastric acid secretion for 60± 90 min in these dogs. With 5% ethanol the plasma gastrin concentration was not affected for 90 min. Combinations of 10% peptone and beer (peptone±beer) or 10% peptone and 5% ethanol (peptone±ethanol) potentiated the acid secretion and increased the plasma gastrin level. While a selective cholecystokinin-B/gastrin receptor antagonist, S-0509, had no effect on ethanolstimulated acid secretion, the compound markedly inhibited both peptone±beer-stimulated and peptone± ethanol-stimulated gastric acid secretion. Famotidine and atropine signi®cantly inhibited gastric acid secretion stimulated by 5% ethanol, peptone±beer and peptone± ethanol. Conclusions: The mechanisms by which peptone±beer and peptone±ethanol stimulate gastric acid secretion may be mediated not only by increased plasma gastrin, but also by the action of histamine and acetylcholine coupled with the increased plasma gastrin. Ethanolstimulated secretion appears to be unrelated to circulating gastrin, yet may be related to the acid regulatory mechanism involving histamine and acetylcholine.

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Section: Discussionmentioning

confidence: 97%

“…Both beer and peptone meal (peptone) potently stimulate gastric acid secretion in laboratory animals 1–3 and humans, 4,5–6 most likely via the stimulation of antral gastrin release. The role of circulating gastrin in the gastric phase of dogs is well recognized following a study using a monoclonal antibody.…”

Section: Introductionmentioning

confidence: 99%

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Matsuno

Sasaki

Okabe

2000

Aliment Pharmacol Ther

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“…Rather, nonalcoholic wine might stimulate histamine release from ECL cells, which in turn could lead to stimulation of histamine H 2 receptors on parietal cells. In fact, Intorre et al 19 reported that red wine (200 mL/dog) significantly increased plasma histamine concentration after intragastric ingestion, probably through participation of ECL cells. Although non-alcoholic wine and ethanol probably stimulate AP accumulation via different pathways, wine did not exhibit any synergistic or potentiated properties.…”

Section: Discussionmentioning

confidence: 99%

Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

Matsuno¹,

Tomita²,

Okabe³

2002

Aliment Pharmacol Ther

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Background & aims: Alcoholic beverages such as beer and wine are well known to potently stimulate gastric acid secretion, most probably through an increase in circulating gastrin level. The present study examined whether or not wine stimulates gastric acid secretion by a direct effect on parietal cells, enterochromaffin‐like (ECL) cells or both. Methods: Gastric mucosa was isolated from female Japanese white rabbits and gland specimens were prepared by the collagenase digestion method. Acid secretion was assessed by gland accumulation of [14C] aminopyrine. The effects of red wine, ethanol, non‐alcoholic wine and drugs were determined by incubating gastric glands with aminopyrine. Radioactivity in solubilized glands was determined by a liquid scintillation counting. Results: Neither wine nor ethanol (diluted 1 : 102 to 1 : 104) had any effect on gastric acid secretion, whereas non‐alcoholic wine stimulated acid secretion in a dose‐dependent manner. All substances, however, significantly stimulated gastric acid secretion in IBMX (phosphodiesterase inhibitor)‐pretreated glands. S‐0509 (a CCK‐2 receptor antagonist) and atropine had no effect on acid secretion stimulated by wine, ethanol or non‐alcoholic wine in IBMX‐pretreated glands. Famotidine and omeprazole significantly inhibited the acid secretion resulting from all of the above stimulants. BAPTA (an intracellular Ca2+ chelator) inhibited acid secretion stimulated with wine or ethanol in a dose‐dependent manner, but did not inhibit secretion stimulated by non‐alcoholic wine. Conclusions: Wine was found to stimulate gastric acid secretion in gastric glands via two pathways, by an ethanol‐induced increase in the concentration of intracellular Ca2+ in parietal cells, and by histamine release from ECL cells potentially induced by constituents present in wine.

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“…However, the general consensus implicated that alcoholic beverages stimulate gastric acid secretion. Indeed, a series of groups observed a rise in histamine, gastrin and carbachol levels following wine and beer ingestion [13][14][15][16]. Paradoxically, this increase in secretagogue concentrations did not occur after consumption of equivalent amount of pure ethanol.…”

Section: Introductionmentioning

confidence: 99%

“…Paradoxically, this increase in secretagogue concentrations did not occur after consumption of equivalent amount of pure ethanol. The stimulatory effect of the beverages was therefore attributed to other ingredients than ethanol [13][14][15][16]. Various groups have thus set out to answer the question of whether pure ethanol influences gastric acid secretion.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Inhibits Gastric Acid Secretion in Rats Through Increased AMP-Kinase Activity

Kopic

Corradini

Sidani

et al. 2010

Cell Physiol Biochem

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The effects of ethanol on gastric acid secretion remain controversial. The present study examines the effect of low-dose (2%) short term (15-20min) ethanol exposure on gastric acid secretion via a potential interaction with AMP-activated protein kinase (AMPK). Real-time fluorescence digital imaging was used to provide functional evidence for the interaction of ethanol and AMPK in modulating secretagogueinduced acid secretion. Individual rat gastric glands were loaded with the pH-sensitive dye BCECF and the secretagogues carbachol (200 µM) or histamine (200 µM) were added to induce secretion. Rates of pH recovery were calculated as ΔpH i /Δt. In one series of experiments, secretagogue-induced acid secretion was inhibited by 2% ethanol, or the AMPK activator AICAR monophosphate (AICAR) (20 mM). In a separate series, 2% ethanol was added in combination with compound C (20 µM), an AMPK inhibitor, to prevent activation of AMPK. 2% ethanol significantly suppressed stimulated acid secretion.In order to confirm modulation of AMPK activity by ethanol, the specific AMPK inhibitor compound C was used, which reversed the inhibitory effects of ethanol on stimulated acid secretion. This study demonstrates that low dose ethanol (2%) inhibits secretagoguedependent acid secretion by activation of the AMPK pathway in rat gastric parietal cells.

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The effect of ethanol, beer, and wine on histamine release from the dog stomach

Cited by 13 publications

References 17 publications

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

Ethanol Inhibits Gastric Acid Secretion in Rats Through Increased AMP-Kinase Activity

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