Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal – the role of endogenous gastrin

Abstract

Aim: To examine the effects of beer, ethanol, peptone meal and combinations of either peptone meal and beer or peptone meal and ethanol on gastric acid secretion in vagally denervated pouch dogs. Methods and Results: The oral administration of either 200 mL of beer, 5% ethanol or 10% peptone meal signi®cantly stimulated gastric acid secretion for 60± 90 min in these dogs. With 5% ethanol the plasma gastrin concentration was not affected for 90 min. Combinations of 10% peptone and beer (peptone±beer) or 10% peptone and 5% ethanol (peptone±ethanol) potentiated the acid secretion and increased the plasma gastrin level. While a selective cholecystokinin-B/gastrin receptor antagonist, S-0509, had no effect on ethanolstimulated acid secretion, the compound markedly inhibited both peptone±beer-stimulated and peptone± ethanol-stimulated gastric acid secretion. Famotidine and atropine signi®cantly inhibited gastric acid secretion stimulated by 5% ethanol, peptone±beer and peptone± ethanol. Conclusions: The mechanisms by which peptone±beer and peptone±ethanol stimulate gastric acid secretion may be mediated not only by increased plasma gastrin, but also by the action of histamine and acetylcholine coupled with the increased plasma gastrin. Ethanolstimulated secretion appears to be unrelated to circulating gastrin, yet may be related to the acid regulatory mechanism involving histamine and acetylcholine.

Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

“…Indeed, we have already reported that S‐0509 significantly inhibits gastric acid secretion induced by beer in Heidenhain pouch dogs 11 , . 12 Nonetheless, in the present study, S‐0509 as well as atropine had little or no effect on wine‐stimulated acid secretion in IBMX‐pretreated glands. It is of interest that only famotidine significantly inhibited the wine‐stimulated gastric acid secretion.…”

“…[7][8][9][10] It has been found that circulating gastrin levels are regularly increased after beer or wine administration and that a selective CCK-2 receptor antagonist inhibits beer-stimulated acid secretion in a dose-dependent manner in dogs. 11,12 Accordingly, an increase in gastrin level has been postulated to be the main driving force behind increased acid secretion. Against this, however, several compounds, including maleic acid and succinic acid, in fermented alcoholic beverages, have been found to stimulate gastric acid secretion without increasing gastrin levels.…”

Endogenous flow of amino acids in the avian ileum as influenced by increasing dietary peptide concentrations

“…Another possibility is that, in addition to the direct protein effect, the EHC may contain bioactive peptides which may have specific effects in modifying the secretion of components of endogenous protein, including digestive enzymes and mucin. Partial hydrolysates of proteins have been shown to be potent stimulants of gastric acid and pancreatic secretions ( 29 , 30 ) . Of particular interest are the findings of Claustre et al ( 31 ) that enzymic hydrolysates of casein induced a strong mucin secretion in rat jejunum and this was attributed to the presence of an opioid peptide, β-casomorphin-7.…”

Identification of Beer Bitter Acids Regulating Mechanisms of Gastric Acid Secretion

“…Findings on the effect of ethanol on gastric acid secretion are controversial. While some studies prove that ethanol has a mild stimulatory effect on gastric acid secretion in concentrations below 5% and no or a slight inhibitory effect in concentrations above 5%, , others found ethanol to be a potent stimulant. , …”