The effect of ethanol and temperature on the structural properties of mesoporous silica synthesized by the sol-gel method

Khodaee, Pegah; Najmoddin, Najmeh; Shahrad, Shima

doi:10.1109/icbme.2018.8703594

Cited by 12 publications

(8 citation statements)

References 3 publications

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“…[ 29 ] demonstrated that the increase in ethanol had decreased the particle size of nanocarriers through decreasing interfacial tension. Some studies confirm our data related to an increase in particle size with an increase in ethanol concentration in nanocarriers [ 30 , 31 , 32 , 33 ]. For example, Khodaee et al.…”

Section: Discussionsupporting

confidence: 89%

“…For example, Khodaee et al. showed that increased ethanol at constant temperature increased the particle size of mesoporous silica nanoparticles [ 30 ]. Another reason to increase particle size in our system with an increase in ethanol concentration would be that increased ethanol may, through non‐linear changes, not be thermodynamically ideal [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Dutasteride nanoemulsion preparation to inhibit 5‐alpha‐hair follicle reductase enzymes in the hair follicle; an ex vivo study

Aval

Hoveizi

Mombeiny

et al. 2022

IET Nanobiotechnology

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Alopecia is a treatable disorder that usually occurs due to high levels of 5-alpha dihydrotestosterone in hair follicles. To enhance the storage capacity of hair follicles and alleviate the inherent characteristics of dutasteride, 5-alpha reductase inhibitor, a prolonged-release nanocarrier was synthesised, and its influence on rat abdomen's skin was investigated. Results showed the lower ratio of S/Co (higher ethanol concentration) increased the hydrodynamic nanocarriers' particle size due to thermodynamic disturbance and Ostwald ripening. In contrast, an increase in surfactant through a decrease in interfacial tension resulted in smaller nanocarriers of 32.4 nm. Moreover, an increase in viscosity had an inverse correlation with the nanoemulsions' particle size. Nanocarriers containing ethanol showed less entrapment efficacy, perhaps due to the rapid dissolution of dutasteride into ethanol during nanoemulsification, while, based on Stokes' equation, the addition of ethanol resulted in smaller particle size and stability of the system. Skin permeation analysis using Franz diffusion cells showed nanocarriers could pass through the skin and release dutasteride for 6 days. In conclusion, the optimum concentration of ingredients is decisive in guaranteeing the ideal particle size, stability, and skin permeation of nanocarriers. The Present dutasteride nanocarrier would promise a prolonged and sustained-release drug delivery system for Alopecia therapy.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Dutasteride nanoemulsion preparation to inhibit 5‐alpha‐hair follicle reductase enzymes in the hair follicle; an ex vivo study

Aval

Hoveizi

Mombeiny

et al. 2022

IET Nanobiotechnology

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“…The use of ethanol slowed down the chemical reaction, and hence the particles acquired a spherical shape with no agglomeration. Ethanol was used in other studies [38,39] and showed similar results with the current study. This phenomenon is probably due to the presence of smaller and more active -OH and -C 2 H 5 groups in ethanol, which is reported to be effective in eliminating water molecules [40] that cause more agglomeration to form larger molecules [39].…”

Section: Fesem/edx and Bet Analyses Of Caco 3 Particles Using Differe...supporting

confidence: 84%

Synthesis and Characterization of Spherical Calcium Carbonate Nanoparticles Derived from Cockle Shells

et al. 2020

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Cockle shells are a natural reservoir of calcium carbonate (CaCO3), which is widely used in bone repair, tissue scaffolds, and the development of advanced drug delivery systems. Although many studies report on the preparation of CaCO3, the development of a nanosized spherical CaCO3 precursor for calcium oxide (CaO) that is suitable to be incorporated in dental material was scarce. Therefore, this study aimed to synthesize a nanosized spherical CaCO3 precursor for CaO derived from cockle shells using a sol–gel method. Cockle shells were crushed to powder form and mixed with hydrochloric acid, forming calcium chloride (CaCl2). Potassium carbonate (K2CO3) was then fed to the diluted CaCl2 to obtain CaCO3. The effect of experimental parameters on the morphology of CaCO3, such as volume of water, type of solvents, feeding rate of K2CO3, and drying method, were investigated using field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffractometry (XRD), Brunauer–Emmett–Teller surface area analysis, and thermogravimetric analysis. Optimized CaCO3 was then calcined to form CaO. XRD analysis of CaCO3 nanoparticles was indicative of the formation of a calcite phase. The well-structured spherical shape of CaCO3 was obtained by the optimum condition of the addition of 50 mL of water into CaCl2 in ethanolic solution with a 1 h feeding rate of K2CO3. Less agglomeration of CaCO3 was obtained using a freeze-drying technique with the surface area of 26 m2/g and average particle size of 39 nm. Spherical shaped nanosized CaO (22–70 nm) was also synthesized. The reproducibility, low cost, and simplicity of the method suggest its potential applications in the large-scale synthesis of the nanoparticles, with spherical morphology in an industrial setting.

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“…Co-surfactants, majorly alcohols such as ethanol [ 88 ] and butanol [ 77 ], affect the pore size and ductility and affect the shapes of the pores as their concentration increases. As the concentration of co-surfactants increases, MSNs tend to lose their spherical shapes, and amorphous particles with various disordered pore sizes are formed [ 89 , 90 ].…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review

2022

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The treatment and management of tuberculosis using conventional drug delivery systems remain challenging due to the setbacks involved. The lengthy and costly treatment regime and patients' non-compliance have led to drug-resistant tuberculosis, which is more difficult to treat. Also, anti-tubercular drugs currently used are poor water-soluble drugs with low bioavailability and poor therapeutic efficiency except at higher doses which causes drug-related toxicity. Novel drug delivery carrier systems such as mesoporous silica nanoparticles (MSNs) have been identified as nanomedicines capable of addressing the challenges mentioned due to their biocompatibility. The review discusses the sol–gel synthesis and chemistry of MSNs as porous drug nanocarriers, surface functionalization techniques and the influence of their physico-chemical properties on drug solubility, loading and release kinetics. It outlines the physico-chemical characteristics of MSNs encapsulated with anti-tubercular drugs.

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The effect of ethanol and temperature on the structural properties of mesoporous silica synthesized by the sol-gel method

Cited by 12 publications

References 3 publications

Dutasteride nanoemulsion preparation to inhibit 5‐alpha‐hair follicle reductase enzymes in the hair follicle; an ex vivo study

Dutasteride nanoemulsion preparation to inhibit 5‐alpha‐hair follicle reductase enzymes in the hair follicle; an ex vivo study

Synthesis and Characterization of Spherical Calcium Carbonate Nanoparticles Derived from Cockle Shells

Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review

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