Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review

Tella, Josephine Oluwagbemisola; Adekoya, J. A.; Ajanaku, K. O.

doi:10.1098/rsos.220013

Cited by 27 publications

(7 citation statements)

References 241 publications

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“…According to the International Union of Pure and Applied Chemistry (IUPAC), a mesoporous material contains pores with widths ranging from 2 to 50 nm. Additionally, microporous pores have dimensions less than 2 nm, while macroporous pores have dimensions greater than 50 nm (Tella et al 2022 ). The nitrogen adsorption-desorption isotherm plot of P-NZVI corresponds to a typical type IV isotherm, indicating the presence of a mesoporous structure according to the IUPAC classification (Du et al 2019 ; Li et al 2022a ).…”

Section: Resultsmentioning

confidence: 99%

Green low-cost synthesis of zero-valent iron nanoparticles from Palm Petiole Extract for Cr(VI) removal from water

Tesnim,

Hédi,

Ridha

et al. 2024

Environ Sci Pollut Res

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One of the hottest research topics over the last decades was the valorization or/and recycling of agro-industrial wastes into different valuable liquid or solid products, which is considered a sustainable and low-cost approach. In this study, we developed zero-valent iron nanoparticles from Palm Petiole Extract (P-NZVI) using a green and straightforward approach. The as-synthesized P-NZVI was used to adsorb Cr(VI) in water. The physico-chemical characterizations of P-NZVI, including the particle size, crystalline structure, surface area, morphology, and functional groups, were investigated via several techniques such as UV-vis spectroscopy, SEM, TEM, XRD, FTIR, AFM, DLS, pHZPC measurement, and BET analysis. The adsorption performance of P-NZVI was studied under different operational parameters, including pollutant concentration, pH, temperature, and adsorbent mass. The adsorption rate was found to be 89.3% within 40 min, corresponding to the adsorption capacity of 44.47 mg/g under the following conditions: initial Cr(VI) concentration of 40 mg/L, pH 5, and a P-NZVI dosage of 1 g/L. It was found that the adsorption pattern follows the Langmuir and the pseudo-second-order kinetic models, indicating a combination of monolayer adsorption and chemisorption mechanisms. The thermodynamic study shows that the adsorption process is endothermic and spontaneous. The reusability of P-NZVI was carried out four times, showing a slight decrease from 89.3 to 87%. These findings highlight that P-NZVI’s could be an effective green adsorbent for removing Cr(VI) or other types of toxic pollutants from water.

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Section: Resultsmentioning

confidence: 99%

Green low-cost synthesis of zero-valent iron nanoparticles from Palm Petiole Extract for Cr(VI) removal from water

Tesnim,

Hédi,

Ridha

et al. 2024

Environ Sci Pollut Res

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“…The following factors influence MSNs particle synthesis [ 61 ]. Rate of silica interaction and condensation Assembly kinetics, nucleation, and growth rates Charge of silica: The rate of silane hydrolysis and condensation of the siloxane bond depends strongly on the charge states.…”

Section: Mesoporous Silica Nanoparticles (Msn)mentioning

confidence: 99%

Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders

et al. 2023

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Complete recovery from infection, sepsis, injury, or trauma requires a vigorous response called inflammation. Inflammatory responses are essential in balancing tissue homeostasis to protect the tissue or resolve harmful stimuli and initiate the healing process. Identifying pathologically important inflammatory stimuli is important for a better understanding of the immune pathways, mechanisms of inflammatory diseases and organ dysfunctions, and inflammatory biomarkers and for developing therapeutic targets for inflammatory diseases. Nanoparticles are an efficient medical tool for diagnosing, preventing, and treating various diseases due to their interactions with biological molecules. Nanoparticles are unique in diagnosis and therapy in that they do not affect the surroundings or show toxicity. Modern medicine has undergone further development with nanoscale materials providing advanced experimentation, clinical use, and applications. Nanoparticle use in imaging, drug delivery, and treatment is growing rapidly owing to their spectacular accuracy, bioavailability, and cellular permeability. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy with several advantages such as easy synthesis, loading, controllability, bioavailability over various surfaces, functionalization, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases. The application of MSNs in the preparation of drug-delivery systems has been steadily increasing in recent decades. Several preclinical studies suggest that an MSN-mediated drug-delivery system could aid in treating inflammatory diseases. This review explains the role of nanoparticles in medicine, synthesis, and functional properties of mesoporous silica nanoparticles and their therapeutic role against various inflammatory diseases.

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“…Mesoporous silica nanoparticles (MSiNPs) have been extensively investigated in the scientific community for producing DDS, serving as a host material to encapsulate or adsorb active ingredients or therapeutic agents [ 10 , 11 , 12 , 13 ], offering a pore network with homogeneous size (50 to 3000 nm), and providing cavities that can host and release a wide variety of molecules. MSiNPs have a uniform and adjustable particle size/shape and are biocompatible [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Environmental Safety Assessment of Dithiocarbazate Loaded Mesoporous Silica Nanoparticles

et al. 2023

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Dithiocarbazates comprise an important class of Schiff bases with remarkable biological applications due to the imine group present in their structure. However, full exploitation of the biological activity of 3-methyl-5-phenyl-pyrazoline-1-(S-benzyldithiocarbazate) (DTC) is limited due to its easy degradation and poor solubility in aqueous solutions. The loading of DTC into mesoporous silica nanoparticles (MSiNPs) can be an excellent strategy to improve the solubility of DTC in the aqueous medium. Therefore, the main goal of the present work was to design MSiNP-DTC and to evaluate the success of the loading process by measuring its physicochemical properties and evaluating the environmental safety of the new DTC formulation using different aquatic organisms, such as the microalgae Raphidocelis subcapitata, the macrophyte Lemna minor, and the marine bacterium Aliivibrio fischeri. DTC, MSiNP, and MSiNP-DTC concentrations ranging from 8.8 to 150 mg L−1 were tested for all the species, showing low toxicity against aquatic organisms. Loading DTC into MSiNPs caused a slight increase in the toxicity at the concentrations tested, only allowing for the estimation of the effect concentration causing a 20% reduction in bioluminescence or growth rate (EC20). Therefore, despite the potential of MSiNPs as a drug delivery system (DDS), it is of utmost importance to assess its impact on the safety of the new formulations.

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Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review

Cited by 27 publications

References 241 publications

Green low-cost synthesis of zero-valent iron nanoparticles from Palm Petiole Extract for Cr(VI) removal from water

Green low-cost synthesis of zero-valent iron nanoparticles from Palm Petiole Extract for Cr(VI) removal from water

Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders

Preparation, Characterization, and Environmental Safety Assessment of Dithiocarbazate Loaded Mesoporous Silica Nanoparticles

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