The Effect of Estrogen on the Gingiva and Alveolar Bone of Molars in Rats and Mice

Nutlay, A.G.; Bhaskar, Surindar N.; Weinmann, Joseph P.; Budy, Ann M.

doi:10.1177/00220345540330010301

Cited by 22 publications

(4 citation statements)

References 10 publications

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“…'4 reported that they did not notice any changes in the epithelial attachment as reported by Nutlay and his co-workers. 15 The present study, too, did not demonstrate consistent proliferation of the epithelial attachment; this may be due to non-consistency in the preparation of the sections. Nevertheless flattening and proliferation of the interdental epithelial papillae was apparent in all histologic sections from estrogen-treated animals; this feature was not seen in the nonestrogen group.…”

contrasting

confidence: 75%

Effects of Simultaneous Administration of Estrogen and Parathyroid Extract upon Teeth, Periodontium, and Long Bones of Growing Albino Mice

Elzay

1964

J Dent Res

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Numerous studies have been carried out concerning the effect of parathyroid extract upon the calcified dental structures and adjacent alveolar bone.1-7 Most of these studies utilized the rat, pigeon, or dog rather than the mouse. This latter animal was employed by Silberberg and Silberberg,8' I but the calcified dental structures and the alveolar process were not evaluated in their studies.In contrast, extensive work has been reported on the effect of estrogens upon the growth of long bones in numerous species of animals. The mouse has been studied probably more extensively than any other animal owing, in part, to the fact that it responds so readily and remarkably to this hormone.'0 However, studies of the effects of estrogens upon tooth structure and associated alveolar bone have not been as extensive or shared the popularity of the corresponding observations upon the long bones."-"' Even less

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contrasting

confidence: 75%

Effects of Simultaneous Administration of Estrogen and Parathyroid Extract upon Teeth, Periodontium, and Long Bones of Growing Albino Mice

Elzay

1964

J Dent Res

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“…Trott (190) noticed a reduction in keratinization of marginal gingival epithelium in postmenopausal women when plasma estrogen levels were declining. In senile mice, estrogens were reported to increase the down‐growth of epithelial attachment (132). Beagrie (9) found an increase in thymidine uptake in murine oral epithelium and epithelial attachment; however, no analysis was attempted to determine if these differences were significant.…”

Section: Putative Etiologies Of Periodontal Endocrinopathiesmentioning

confidence: 99%

Endocrinology of sex steroid hormones and cell dynamics in the periodontium

Mariotti¹,

Mawhinney²

2012

Periodontology 2000

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Numerous scientific studies assert the existence of hormone-sensitive periodontal tissues. Tissue specificity of hormone localization, identification of hormone receptors and the metabolism of hormones are evidence that periodontal tissues are targets for sex steroid hormones. Although the etiologies of periodontal endocrinopathies are diverse, periodontal pathologies are primarily the consequence of the actions and interactions of sex steroid hormones on specific cells found in the periodontium. This review provides a broad overview of steroid hormone physiology, evidence for the periodontium being a target tissue for sex steroid hormones and theories regarding the roles of sex steroid hormones in periodontal pathogenesis. Using this information, a teleological argument for the actions of steroid hormones in the periodontium is assessed.

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“…It is conceivable that these structures react to changes in endocrine activity in a similar way as does the connective tissue in other parts of the body. Sex hormones -presumably mainly estrogensmay alter connective tissue in various ways: 1) estrogens have been shown to be involved in synthesis of collagen and to take part in endosteal bone formation (Urist et al, 1950, Shklar and Glickman 1956, Nutlay et al 1954, 2) estrogens may depolymerize muco-polysaccharides of the ground substance and, at the same time, lead to an increase in the sodium and chloride content of connective tissue which causes water retention and edema, 3) estrogens may increase vascular permeability and may produce hyperemia (Labhart 1957, Kaufmann and Zander 1959, Gersh and Catchpole 1960, Diczfalusy and Lauritzen 1961, Schifl" 1966. These combined efTects should alter the biophysical properties of the connective tissue system, ln respect to the tooth supporting structures, this would be reflected by less resistance towards forces acting on the crown of teeth and accordingly by an increased tooth mobility.…”

mentioning

confidence: 99%

Tooth mobility changes in pregnancy

Rateitschak¹

1967

J of Periodontal Research

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Horizontal tooth mobility of the upper incisors was repeatedly measured with the macroperiodontometer in 7 subjects during pregnancy and until several months after delivery. In 6 periodontally healthy females, a small but statistically significant average change in mobility was found. Mobility was highest during the last month of pregnancy. One subject with moderate symptoms of periodontitis and with pathological mobility exhibited a pronounced mobility increase which, 6 months post partum, had not returned to the levels determined at the third month of pregnancy. Increase of mobility during pregnancy was apparently caused by alterations of the periodontal membrane and not of the alveolar socket bone.

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The Effect of Estrogen on the Gingiva and Alveolar Bone of Molars in Rats and Mice

Cited by 22 publications

References 10 publications

Effects of Simultaneous Administration of Estrogen and Parathyroid Extract upon Teeth, Periodontium, and Long Bones of Growing Albino Mice

Effects of Simultaneous Administration of Estrogen and Parathyroid Extract upon Teeth, Periodontium, and Long Bones of Growing Albino Mice

Endocrinology of sex steroid hormones and cell dynamics in the periodontium

Tooth mobility changes in pregnancy

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