The Effect of Estradiol and Irradiation on the Nucleic Acid Metabolism of the Thymus, Spleen, Lymph Node, and Liver of Mice

Oral contraceptives and liver function

“…In animals repeated doses of oestrogens (Gallagher et al, 1960) and progesterone (Hines, 1967) will increase liver weight. A single dose of oestrogen will not, however, increase liver weight (Thompson, Severson, and Reilly, 1966) although it will induce rapid uterine growth. The RNA content of liver is greatly increased in rats during pregnancy , the increase exceeding the increase observed for protein.…”

Accumulation and binding of 3H-estradiol-17.BETA. by lymphoid tissues of castrated mice.

“…Sherman et al (1963) reported that estrogen administration to neonatally thymectomized hamsters prevented wasting, whereas oophorectomy in neonatally thymectomized females permitted wasting. On the contrary, Dougherty (1952), Kappas and Palmer (1963) and Thompson et al(1966) have shown that estrogen administration caused thymic involution in the intact animals, but its effect on lymphoid tissues other than the thymus was minimal and quite variable, depending on the species used. When estrogen was administered to newborn mice, it induced wasting syndrome with central and peripheral lymphoid hypoplasia .…”

Cytoplasmic estrogen receptor in castrated rat thymus.

“…Estrogen, like adrenocortical hormones, regularly induces acute involution of the thymus in intact animals (Dougherty, 1952 ;Thompson et al, 1966), but its effect on lymphoid tissues other than the thymus is minimal and quite variable. According to , and Thompson et al(1966), this involution is due to total loss of the cortex and reduced cellularity in the shrunken medullary area of estrogen-treated mouse thymus, which is characterized by diminished nucleic acid content and deoxyribonucleic acid synthesis within the tissue.…”

“…According to , and Thompson et al(1966), this involution is due to total loss of the cortex and reduced cellularity in the shrunken medullary area of estrogen-treated mouse thymus, which is characterized by diminished nucleic acid content and deoxyribonucleic acid synthesis within the tissue. In the review by Dougherty (1952), it is mentioned that estrogen exerts its moderating action on the thymus by continuously destroying lymphocytes.…”