“…Secondly the stimulant action of histamine, a diamine, on the perfused rabbit auricular artery (Carroll & others, 1972) was also strongly enhanced by ergotamine. Finally, although quantitative comparisons are difficult, inhibition of monoamine uptake can only be demonstrated at concentrations of ergotamine greater than those causing sensitization (Dengler, Spiegel & Titus, 1961 ;Salzmann & others, 1968;Lingjaerde, 1970;Salzmann & Kalberer, 1973), if at all (Fozard & Berry, 1974). A more plausible explanation has been advanced by Weidmann & Taeschler (1966), based on the observations that ergotamine in higher concentrations stimulates those preparations in which an enhancement of stimulation is seen.…”