New Studies on the Circulatory Effects of Ergot Compounds with Implications to Migraine

Berde, B.

doi:10.1007/978-1-4757-4577-1_9

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…It is generally believed that ergot alkaloids are effective in the treatment of migraine by a constrictor action on arteries. However, Berde 31 and Saxena et a1 32 suggested that the degree of vasoconstriction induced by ergot derivatives depends on preexisting vascular tone. Berde found that when the arterial resistance of the perfused dog hindlimb was low, ergot derivatives constricted the vasculature whereas when the resistance was high the drugs had vasodilator actions.…”

Section: Discussionmentioning

confidence: 99%

Autonomic Nervous System Dysfunction in Common Migraine

et al. 1985

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SYNOPSIS Common migraine has been related to both dysfunction of the autonomic nervous system (A.N.S.) in the regulation of cerebral vasomotor tonicity and to neurotic and depressive tendencies. In the present study 86 normal healthy controls and 50 patients with common migraine were studied in order to determine whether tonic or phasic central autonomic nervous system dysfunction was concomitant with migraine during a headache‐free, medication‐free interval. pupillometry was employed to measure relevant parameters of sympathetic and parasympathetic activity at rest and during the cold pressor test. Concomitantly, measurements of neuroticism, anxiety and depression were also obtained. Migraineurs were not identifiably different from controls with respect to tonic sympathetic or parasympathetic activity nor were they distinguishable on measures of supranuclear inhibition. However, 70% of migraineurs manifested phasic hyposympathetic activity in response to the cold pressor test. These migraineurs also demonstrated more neurotic and depressive tendencies. The physiological dysfunction was shown to differentiate the groups of migraineurs after personality variables were statistically controlled by a covariance multiple regression analysis. Results of the study are discussed in relationship to cerebral blood flow and permeability of the cerebral vasculature.

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Section: Discussionmentioning

confidence: 99%

Autonomic Nervous System Dysfunction in Common Migraine

et al. 1985

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“…Further, as ligands, ergot alkaloids can interfere at more than one receptor site [ 22 ] and the basic activity will vary from alkaloid to alkaloid [ 26 , 27 ] as a result of slight structural differences [ 28 ]. As ligands, ergot alkaloids can also act as agonists (stimulatory), partial agonists, and antagonists at the same receptor sites [ 29 ]. Consequently, there are a large number of outcomes in terms of ergot alkaloid-receptor interactions.…”

Section: Ergot Alkaloid Activitymentioning

confidence: 99%

Activities and Effects of Ergot Alkaloids on Livestock Physiology and Production

Klotz

2015

Toxins

138

141

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Consumption of feedstuffs contaminated with ergot alkaloids has a broad impact on many different physiological mechanisms that alters the homeostasis of livestock. This change in homeostasis causes an increased sensitivity in livestock to perturbations in the ambient environment, resulting in an increased sensitivity to such stressors. This ultimately results in large financial losses in the form of production losses to livestock producers around the world. This review will focus on the underlying physiological mechanisms that are affected by ergot alkaloids that lead to decreases in livestock production.

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Part 1: Migraine Headaches

Friedman¹

1972

JAMA

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New Studies on the Circulatory Effects of Ergot Compounds with Implications to Migraine

Cited by 6 publications

References 4 publications

Autonomic Nervous System Dysfunction in Common Migraine

Autonomic Nervous System Dysfunction in Common Migraine

Activities and Effects of Ergot Alkaloids on Livestock Physiology and Production

Part 1: Migraine Headaches

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