The effect of engineered PLGA nanoparticles on nitrifying bacteria in the soil environment

Nishu, Susmita Das; Park, Seungbin; Ji, Yuhyun; Han, Il Ki; Key, Jaehong; Lee, Tae Kwon

doi:10.1016/j.jiec.2020.01.011

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…Thirty-five (29.9%) studies reported on carbon-based nanoparticles (including single and multi-walled carbon nanotubes (SWCNTs/MWCNTs), graphene oxide (GO), and graphene nanoplatelets, GNP). Three studies [ 21 – 23 ] reported on both inorganic- and carbon-based nanoparticles; one study [ 24 ] reported on both inorganic-based and polymer nanoparticles (i.e., Titanium dioxide, terbium-doped gadolinium, and polylactic-co-glycolic acid, PLGA), whereas another study [ 25 ] investigated the effect of Poly lactic-co-glycolic acid (a polymer) nanoparticle on the environment.…”

Section: Resultsmentioning

confidence: 99%

“…Workplace air samples have also been used to investigate workplace exposures to graphene nanoplatelets [ 26 ]. Five studies [ 25 , 27 – 30 ] that reported on the environmental effect of nanoparticles used a variety of biomarkers, including soil samples and soybean seeds, Allium cepa bulbs, zebrafish larvae, seedlings of buckwheat, Nitrosomonas europaea KCTC 12270 bacterium (an ammonia-oxidizing bacterium) and Nitrospira moscoviensis (a nitrite-oxidizing bacterium), as well as aquatic species including Daphnia magna neonates, fish, and Carp (Cyprius carpio). The studies included in this review reported several toxicities associated with the production and application of nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

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Human and environmental impacts of nanoparticles: a scoping review of the current literature

et al. 2023

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Use of nanoparticles have established benefits in a wide range of applications, however, the effects of exposure to nanoparticles on health and the environmental risks associated with the production and use of nanoparticles are less well-established. The present study addresses this gap in knowledge by examining, through a scoping review of the current literature, the effects of nanoparticles on human health and the environment. We searched relevant databases including Medline, Web of Science, ScienceDirect, Scopus, CINAHL, Embase, and SAGE journals, as well as Google, Google Scholar, and grey literature from June 2021 to July 2021. After removing duplicate articles, the title and abstracts of 1495 articles were first screened followed by the full-texts of 249 studies, and this resulted in the inclusion of 117 studies in the presented review.In this contribution we conclude that while nanoparticles offer distinct benefits in a range of applications, they pose significant threats to humans and the environment. Using several biological models and biomarkers, the included studies revealed the toxic effects of nanoparticles (mainly zinc oxide, silicon dioxide, titanium dioxide, silver, and carbon nanotubes) to include cell death, production of oxidative stress, DNA damage, apoptosis, and induction of inflammatory responses. Most of the included studies (65.81%) investigated inorganic-based nanoparticles. In terms of biomarkers, most studies (76.9%) used immortalised cell lines, whiles 18.8% used primary cells as the biomarker for assessing human health effect of nanoparticles. Biomarkers that were used for assessing environmental impact of nanoparticles included soil samples and soybean seeds, zebrafish larvae, fish, and Daphnia magna neonates.From the studies included in this work the United States recorded the highest number of publications (n = 30, 25.64%), followed by China, India, and Saudi Arabia recording the same number of publications (n = 8 each), with 95.75% of the studies published from the year 2009. The majority of the included studies (93.16%) assessed impact of nanoparticles on human health, and 95.7% used experimental study design. This shows a clear gap exists in examining the impact of nanoparticles on the environment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Human and environmental impacts of nanoparticles: a scoping review of the current literature

et al. 2023

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“…The computational system was created to mimic a representative volume element of curcumin-loaded PLGA DPPs (see Fig. 1 a) [ 41 , 42 ]. Thus, the simulated system consisted of a curcumin molecule immersed in a box composed by PLGA chains and filled with water (see Fig.…”

Section: Methodsmentioning

confidence: 99%

Diffusion of curcumin in PLGA-based carriers for drug delivery: a molecular dynamics study

De Giorgi,

Bellussi,

Parlani

et al. 2024

J Mol Model

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Context: The rapid growth and diversification of drug delivery systems have been significantly supported by advancements in micro- and nano-technologies, alongside the adoption of biodegradable polymeric materials like poly(lactic-co-glycolic acid) (PLGA) as microcarriers. These developments aim to reduce toxicity and enhance target specificity in drug delivery. The use of in silico methods, particularly molecular dynamics (MD) simulations, has emerged as a pivotal tool for predicting the dynamics of species within these systems. This approach aids in investigating drug delivery mechanisms, thereby reducing the costs associated with design and prototyping. In this study, we focus on elucidating the diffusion mechanisms in curcumin-loaded PLGA particles, which are critical for optimizing drug release and efficacy in therapeutic applications. Methods: We utilized MD to explore the diffusion behavior of curcumin in PLGA drug delivery systems. The simulations, executed with GROMACS, modeled curcumin molecules in a representative volume element of PLGA chains and water, referencing molecular structures from the Protein Data Bank and employing the CHARMM force field. We generated PLGA chains of varying lengths using the Polymer Modeler tool and arranged them in a bulk-like environment with Packmol. The simulation protocol included steps for energy minimization, T and p equilibration, and calculation of the isotropic diffusion coefficient from the mean square displacement. The Taguchi method was applied to assess the effects of hydration level, PLGA chain length, and density on diffusion. Results: Our results provide insight into the influence of PLGA chain length, hydration level, and polymer density on the diffusion coefficient of curcumin, offering a mechanistic understanding for the design of efficient drug delivery systems. The sensitivity analysis obtained through the Taguchi method identified hydration level and PLGA density as the most significant input parameters affecting curcumin diffusion, while the effect of PLGA chain length was negligible within the simulated range. We provided a regression equation capable to accurately fit MD results. The regression equation suggests that increases in hydration level and PLGA density result in a decrease in the diffusion coefficient.

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“…Of great concern is the potential for CRSs to have negative effects on the soil ecosystem. For example, common biomedical CRS materials, such as PEG and PLGA, are difficult to degrade to monomers, have monomers that could persist in soils, or can acidify soil (Plaut and Federman, 1985;Nishu et al, 2020). Even for some currently accepted agricultural materials (e.g., polyacrylamide), there is debate as to the longterm environmental consequences (Chen and Chen, 2019).…”

Section: Challenges In Agricultural Controlled Releasementioning

confidence: 99%

Translating controlled release systems from biomedicine to agriculture

Lee

Lin²,

Khan³

et al. 2022

Front. Biomater. Sci.

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Sustainable food production is a grand challenge facing the global economy. Traditional agricultural practice requires numerous interventions, such as application of nutrients and pesticides, of which only a fraction are utilized by the target crop plants. Controlled release systems (CRSs) designed for agriculture could improve targeting of agrochemicals, reducing costs and improving environmental sustainability. CRSs have been extensively used in biomedical applications to generate spatiotemporal release patterns of targeted compounds. Such systems protect encapsulant molecules from the external environment and off-target uptake, increasing their biodistribution and pharmacokinetic profiles. Advanced ‘smart’ release designs enable on-demand release in response to environmental cues, and theranostic systems combine sensing and release for real-time monitoring of therapeutic interventions. This review examines the history of biomedical CRSs, highlighting opportunities to translate biomedical designs to agricultural applications. Common encapsulants and targets of agricultural CRSs are discussed, as well as additional demands of these systems, such as need for high volume, low cost, environmentally friendly materials and manufacturing processes. Existing agricultural CRSs are reviewed, and opportunities in emerging systems, such as nanoparticle, ‘smart’ release, and theranostic formulations are highlighted. This review is designed to provide a guide to researchers in the biomedical controlled release field for translating their knowledge to agricultural applications, and to provide a brief introduction of biomedical CRSs to experts in soil ecology, microbiology, horticulture, and crop sciences.

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The effect of engineered PLGA nanoparticles on nitrifying bacteria in the soil environment

Cited by 6 publications

References 47 publications

Human and environmental impacts of nanoparticles: a scoping review of the current literature

Human and environmental impacts of nanoparticles: a scoping review of the current literature

Diffusion of curcumin in PLGA-based carriers for drug delivery: a molecular dynamics study

Translating controlled release systems from biomedicine to agriculture

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