Human and environmental impacts of nanoparticles: a scoping review of the current literature

Kumah, Elizabeth Adjoa; Fopa, Raoul Djou; Harati, Saeed; Boadu, Paul; Zohoori, F. V.; Pak, Tannaz

doi:10.1186/s12889-023-15958-4

Cited by 68 publications

(17 citation statements)

References 157 publications

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“…The integration of multiple activities within a single molecular entity has been used to design stable and potent peptide inhibitors of the Nrf2-KEAP1 pathway with optimal cellular uptake and resistance against degradation in human serum [ 276 ]. Investigating the long-term stability and biodegradability of the nano-carriers would be essential from both environmental and systemic health standpoints [ 277 ]. Furthermore, due to selectivity, potency, pharmacokinetic properties, and the ready availability of diagnostics for assessing NQO1 in patients, some NQO1 substrates such as deoxynyboquinone, have considerable potential as personalized medicines for the treatment of various disorders, such as brain tumors [ 278 ].…”

Section: Developing Novel Therapeutic And/or Diagnostic Compounds By ...mentioning

confidence: 99%

Impact of NQO1 dysregulation in CNS disorders

Yuhan,

Khaleghi Ghadiri,

Gorji

2024

J Transl Med

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NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous system (CNS). Impairment of the NQO1 activity in the CNS can result in abnormal neurotransmitter release and clearance, increased oxidative stress, and aggravated cellular injury/death. Furthermore, it can cause disturbances in neural circuit function and synaptic neurotransmission. The abnormalities of NQO1 enzyme activity have been linked to the pathophysiological mechanisms of multiple neurological disorders, including Parkinson's disease, Alzheimer's disease, epilepsy, multiple sclerosis, cerebrovascular disease, traumatic brain injury, and brain malignancy. NQO1 contributes to various dimensions of tumorigenesis and treatment response in various brain tumors. The precise mechanisms through which abnormalities in NQO1 function contribute to these neurological disorders continue to be a subject of ongoing research. Building upon the existing knowledge, the present study reviews current investigations describing the role of NQO1 dysregulations in various neurological disorders. This study emphasizes the potential of NQO1 as a biomarker in diagnostic and prognostic approaches, as well as its suitability as a target for drug development strategies in neurological disorders.

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Section: Developing Novel Therapeutic And/or Diagnostic Compounds By ...mentioning

confidence: 99%

Impact of NQO1 dysregulation in CNS disorders

Yuhan,

Khaleghi Ghadiri,

Gorji

2024

J Transl Med

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“…The term nanoparticles originated from the Greek term nano, meaning small or dwarf, with dimensions not exceeding 100 nanometers [ 1 ]; nanoparticles were also defined by [ 2 ] as extremely small particles having the ability to dissolve and having one or more dimensions than the external dimensions. Moreover, nanoparticles have recently received great attention due to their unique properties, which have contributed to wide areas of use such as the medical and industrial fields [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Oxide Nanoparticles on Liver Functions in Albino Mice

Al-Ragi,

Karieb,

Fathallah

et al. 2024

Cureus

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Background: An alarming number of zinc oxide nanoparticles (ZnO-NPs) have leaked into the environment, endangering the tissues of many living creatures, due to the recent surge in their use in several items. Through intra-peritoneal injection, this research intends to examine the impact of ZnO-NPs on the hepatic and gastrointestinal structures of male albino mice. Method: For seven and 14 days, animals were given 0.1 ml of 100 and 200 mg kg-1 of 50 nm-size ZnO-NPs, respectively. In contrast, those in the control group were given only water and food. Result: The results demonstrated that the treated mice's livers underwent functional changes and histological damage. After seven and 14 days, there was a notable rise in the average levels of the glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase enzymes in comparison to the control group (p≤0.05). Concentration time determines the magnitude of this impact. When enzyme levels vary, it means the liver isn't working properly. Histological changes in the liver, such as necrosis, destruction of hepatocyte membranes, widening of sinusoidal spaces and vacuolation of their cytoplasm, vascular congestion, and an increased number of Kupffer cells, were induced in mice treated with ZnO-NPs at two studied concentrations (100 and 200 mg/kg) for seven and 14 days, respectively. These effects were time-dose-dependent, according to the results of hematoxylin-eosin staining of liver tissue images.

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“…Some strategies have been developed in the past to design self-cleaning plastics with anti-microbial properties ( 11 ). However, these methods can be expensive and toxic to humans and the environment ( 12 ). An alternate approach is to explore natural organic products as potential antivirals.…”

Section: Introductionmentioning

confidence: 99%

Antiviral action of a functionalized plastic surface against human coronaviruses

Shroff,

Haapakoski,

Tapio

et al. 2024

Microbiol Spectr

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Viruses may persist on solid surfaces for long periods, which may contribute to indirect transmission. Thus, it is imperative to develop functionalized surfaces that will lower the infectious viral load in everyday life. Here, we have tested a plastic surface functionalized with tall oil rosin against the seasonal human coronavirus OC43 as well as severe acute respiratory syndrome coronavirus 2. All tested non-functionalized plastic surfaces showed virus persistence up to 48 h. In contrast, the functionalized plastic showed good antiviral action already within 15 min of contact and excellent efficacy after 30 min over 90% humidity. Excellent antiviral effects were also observed at lower humidities of 20% and 40%. Despite the hydrophilic nature of the functionalized plastic, viruses did not adhere strongly to it. According to helium ion microscopy, viruses appeared flatter on the rosin-functionalized surface, but after flushing away from the rosin-functionalized surface, they showed no apparent structural changes when imaged by transmission electron microscopy of cryogenic or negatively stained specimens or by atomic force microscopy. Flushed viruses were able to bind to their host cell surface and enter endosomes, suggesting that the fusion with the endosomal membrane was halted. The eluted rosin from the functionalized surface demonstrated its ability to inactivate viruses, indicating that the antiviral efficacy relied on the active leaching of the antiviral substances, which acted on the viruses coming into contact. The rosin-functionalized plastic thus serves as a promising candidate as an antiviral surface for enveloped viruses. IMPORTANCE During seasonal and viral outbreaks, the implementation of antiviral plastics can serve as a proactive strategy to limit the spread of viruses from contaminated surfaces, complementing existing hygiene practices. In this study, we show the efficacy of a rosin-functionalized plastic surface that kills the viral infectivity of human coronaviruses within 15 min of contact time, irrespective of the humidity levels. In contrast, non-functionalized plastic surfaces retain viral infectivity for an extended period of up to 48 h. The transient attachment on the surface or the leached active components do not cause major structural changes in the virus or prevent receptor binding; instead, they effectively block viral infection at the endosomal stage.

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Human and environmental impacts of nanoparticles: a scoping review of the current literature

Cited by 68 publications

References 157 publications

Impact of NQO1 dysregulation in CNS disorders

Impact of NQO1 dysregulation in CNS disorders

Effect of Zinc Oxide Nanoparticles on Liver Functions in Albino Mice

Antiviral action of a functionalized plastic surface against human coronaviruses

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