The effect of endocervical gland involvement on the cure rates of patients with cervical intraepithelial neoplasia undergoing cryosurgery

Savage, Edward W.; Matlock, David L.; Salem, Frank A.; Charles, Elsworth H.

doi:10.1016/0090-8258(82)90089-0

Cited by 15 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[16–20] It has been demonstrated that after LEEP, EGI was predictive of residual/recurrent dysplasia. [1–3] Livacy et al . [3] found an association between EGI and recurrent dysplasia independent of margin status in LEEP cones.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Therefore, information concerning gland involvement should influence patient management; the option of deeper conization may have advantages over LEEP or cryotherapy to ensure negative margins for suitable patients. [1–8]…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that there is an association between EGI and recurrent dysplasia, even independent of the margin status in loop electrocautery excision procedure (LEEP) cones. [1–3] Several authors reported an increased failure rate using cryotherapy when the endocervical glands were involved in cervical intraepithelial neoplasia (CIN). [3] The information concerning EGI on Pap smears may influence the decision to perform deeper conization, LEEP biopsy or cryotherapy to ensure negative margins.…”

Section: Introductionmentioning

confidence: 99%

“…[3] The information concerning EGI on Pap smears may influence the decision to perform deeper conization, LEEP biopsy or cryotherapy to ensure negative margins. [1–8]…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions

Kır

Karabulut

Yılmaz

et al. 2012

J Cytol

View full text Add to dashboard Cite

Background:Diagnosis of endocervical glandular involvement by high-grade squamous intraepithelial lesion (HSIL-EGI) on Papanicolaou (Pap) smears can affect the clinical management of patients.Aim:The cytological criteria for the diagnosis of HSIL-EGI are described and the accuracy of this diagnosis was investigated.Materials and Methods:Seventeen patients diagnosed with HSIL-EGI and 40 patients with diagnosis of HSIL on Pap smears with follow-up cone or loop electrocautery excision procedure (LEEP) biopsies were included in the study. The following criteria were evaluated for the cytological diagnosis of HSIL-EGI: atypical cells with definite features of HSIL, three-dimensional atypical squamous cell clusters (TDCs) with attached benign endocervical epithelium, finger-like TDCs covered with intact epithelium on most sides, which represent the finger-like invaginations of the endocervical glandular area involved by HSIL, and the absence of cytological findings of in situ adenocarcinoma of the cervix.Results:On subsequent histopathological evaluation, 16 of 17 (94.1%) patients with a cytological diagnosis of HSIL-EGI and 17 of 40 (42.5%) patients with HSIL exhibited endocervical glandular involvement (P < 0.001, sensitivity: 48.5%, specificity: 95.8%, positive predictive value: 94.1%, negative predictive value: 57.5% and accuracy: 68.4%).Conclusion:Diagnosis of HSIL-EGI may be possible on Pap smears with a high positive predictive value and specificity but low sensitivity, possibly due to cytological sampling limitations. To clarify the results of the present study, more extensive studies with a particular emphasis on the sampling of the endocervical glandular area for cytological evaluation of the cervix are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[3] The information concerning EGI on Pap smears may influence the decision to perform deeper conization, LEEP biopsy or cryotherapy to ensure negative margins. [1–8]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions

Kır

Karabulut

Yılmaz

et al. 2012

J Cytol

View full text Add to dashboard Cite

show abstract

“…Such a finding on cervical smear would alert the gynaecologist to perform a thorough assessment of the endocervix during colposcopy. Glandular involvement by CIN2+ in a cone biopsy is associated with a higher incidence of positive margins 20 and with a poorer response to cryosurgery 21 . Its accurate identification on a smear could help decide on the need to perform deeper conization rather than LEEP to ensure negative margins in cases where colposcopic biopsy shows CIN 2 or 3 21 …”

Section: Discussionmentioning

confidence: 99%

Diverse glandular pathologies coexist with high‐grade squamous intraepithelial lesion in cyto‐histological review of atypical glandular cells on ThinPrep specimens

et al. 2009

View full text Add to dashboard Cite

Special efforts to recognize endocervical glandular extension in high-grade squamous intraepithelial lesions and glandular neoplasia coexisting with squamous intraepithelial lesions from the heterogeneous category of AGC can contribute to increasing the diagnostic accuracy. The identification of endocervical glandular extension on cervical cytology would alert the gynaecologist to perform a thorough assessment of the endocervix during colposcopy. This could also help to decide on the need to perform deeper conization rather than loop electrosurgical excision procedure to ensure negative margins when colposcopic biopsy shows CIN 2 or 3.

show abstract

Endocervical gland involvement by cervical intraepithelial neoplasia grade III. predictive value for residual and/or recurrent disease

Demopoulos

Horowitz

Vamvakas

1991

Cancer

View full text Add to dashboard Cite

The prognostic significance for residual or recurrent disease of cervical intraepithelial neoplasia Grade III in endocervical glands by cone biopsy was examined in 341 consecutive patients diagnosed from 1979 through 1983 and followed through 1988. Treatment by hysterectomy, within 8 weeks of cone biopsy, was done in 96 patients. The only variable that could predict residual disease at hysterectomy was positive margins (P = 0.059). However, both positive margins and positive glands were (independently of one another and after the effects of length of follow‐up, hospital of admission, and age at time of first diagnosis were held constant) highly significant predictors of residual or recurrent disease in the 245 women who did not undergo a hysterectomy (P = 0.000 for each). The authors therefore conclude that information concerning gland involvement on cone biopsy specimens should influence patient management.

show abstract

The effect of endocervical gland involvement on the cure rates of patients with cervical intraepithelial neoplasia undergoing cryosurgery

Cited by 15 publications

References 6 publications

Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions

Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions

Diverse glandular pathologies coexist with high‐grade squamous intraepithelial lesion in cyto‐histological review of atypical glandular cells on ThinPrep specimens

Endocervical gland involvement by cervical intraepithelial neoplasia grade III. predictive value for residual and/or recurrent disease

Contact Info

Product

Resources

About