Diverse glandular pathologies coexist with high‐grade squamous intraepithelial lesion in cyto‐histological review of atypical glandular cells on ThinPrep specimens

Kumar, Neeta; Bongiovanni, Massimo; Molliet, M-J; Pelte, Marie‐Françoise; Egger, Jean-François; Pache, Jean–Claude

doi:10.1111/j.1365-2303.2008.00568.x

Cited by 22 publications

(22 citation statements)

References 16 publications

(33 reference statements)

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“…Kumar et al . reported that glandular lesions and squamous epithelial lesions of the uterine cervix are coexistent at a frequency of 62% (20). In our study, squamous epithelial lesions were detected in 6 (14.6%) of 41 patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Atypical Glandular Cells in the Bethesda System 2001: A Comparison with the Histopathological Diagnosis of Surgically Resected Specimens

Shoji¹,

Takatori²,

Takeuchi³

et al. 2014

Cancer Investigation

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Forty-one patients diagnosed with atypical glangular cells (AGC) underwent surgery, and the histopathological diagnosis results for the resected specimens and the clinical features were analyzed. Out of 41 patients, final pathological diagnosis was endometrial cancer in 13 patients, cervical adenocarcinoma in 8, AIS in 7, CIN3 in 6, others in 2, and no lesions in 5. In comparison with previous reports, malignant or premalignant lesions were detected more frequently in patients with AGC who underwent surgery. We believe that conization or hysterectomy aimed at diagnosis and treatment, as well as endometrial histodiagnosis, should be carried out aggressively in patients with AGC.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Atypical Glandular Cells in the Bethesda System 2001: A Comparison with the Histopathological Diagnosis of Surgically Resected Specimens

Shoji¹,

Takatori²,

Takeuchi³

et al. 2014

Cancer Investigation

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“…There are only limited reports on dual Pap test interpretations using Bethesda terminology with subsequent histopathologic correlation. In a retrospective study, Kumar et al identified 24 of 39 (62%) ThinPrep Pap tests with an initial interpretation of atypical glandular cells of undetermined significance (AGUS) which had subsequent histopathologic diagnoses of HSIL (CIN2/3) on cone biopsy. The cytology and histology slides were reviewed and reinterpreted to identify HSIL extension into glands employing the Bethesda 2001 system.…”

Section: Discussionmentioning

confidence: 99%

Papanicolaou tests with coexisting squamous and glandular abnormalities

Khor

Abdul‐Karim

Bruening

et al. 2014

Cancer Cytopathology

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identified. Follow-up pathology results on these patients were predominantly squamous lesions (51.7%). Glandular lesions only were detected in 14 cases (6.1%). Nine (3.9%) patients had both squamous and glandular pathology. CONCLUSIONS:Over a 6-year period, dual Pap test interpretations with both squamous and glandular atypia were more often associated with squamous than glandular lesions. Dual interpretations did identify coexisting squamous and glandular lesions. However, the number of cases was small. Cancer (Cancer Cytopathol) 2014;122:620-6.

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“…When infected by HPV, these cells can account for a similar morphological range of lesions, including mature and immature squamous (eg, mature low-grade squamous intraepithelial lesions, immature condylomata, immature “metaplastic” high-grade squamous intraepithelial lesions), columnar (adenocarcinoma in situ) or a combination (stratified mucinous intraepithelial lesions) 28. Diverse glandular pathologies (endocervical glandular extension, glandular dysplasia/cervical glandular intraepithelial neoplasia and adenocarcinoma in situ) coexist with high-grade squamous intraepithelial lesions 29. The transformation of cellular type in the cervix is similar to the genetic switch in the pluripotential stem cells of the basal layer of the squamous epithelium of the oesophagus into metaplastic specialised columnar lining 10…”

Section: Evidence For An Analogous Association Between Human Papillommentioning

confidence: 99%

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

Rajendra

Robertson²

2009

J Clin Pathol

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There are a number of similarities between cervical cancer and oesophageal adenocarcinoma. As cervical cancer is overwhelmingly associated with oncogenic human papillomavirus (HPV) infection, the possibility that HPV is also associated with the aetiology of oesophageal adenocarcinoma needs to be examined. This paper presents the evidence for such an association and a discussion of what further studies would be needed to confirm such an association. EVIDENCE FOR AN ANALOGOUS ASSOCIATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND CERVICAL CANCER AND OESOPHAGEAL ADENOCARCINOMAHPV has been identified as the major aetiological factor in cervical carcinogenesis, 1 being detected in 90-100% of cervical cancer specimens compared with 20% of controls. 2 In addition, the HPV viral genome has been identified in most of the precursor lesions of cervical intraepithelial neoplasia. 3 HPVs are epitheliotropic and were thought to preferentially infect squamous epithelia only. However, it is now known that much of the virus is present at the squamocolumnar junction. Moreover, a consistent, strong and robust association between infection by high-risk HPV types and risk of development of adenocarcinoma of the cervix has been demonstrated. 4 5The role of HPV-mediated tumorigenesis in cervical cancer raises the question of the possible pathogenic role of the virus in oesophageal squamous and adenocarcinoma, oropharyngeal cancers and other non-genital malignancies. The recent demonstration of an association between HPV infection and oropharyngeal cancers, and the demonstration that this association may be related to direct or indirect orogenital transmission, reveals the exposure of the upper gastrointestinal tract to HPV infection. 6 There is some evidence for a plausible role for HPV in the pathogenesis of squamous cell carcinoma of the oesophagus. 7 High-risk-type HPV infections (predominantly HPV16 and HPV18) are detected in about 15% and 23% of patients with oesophageal squamous carcinoma using PCR and in situ hybridisation techniques, respectively. 7 HPV detection rates in oesophageal cancer are highly variable in different geographical areas of the world and are significantly higher in high-risk areas than in low-risk regions. 7 Oesophageal squamous papillomas are believed to arise from a multistep process involving HPV and chronic reflux. 8

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Diverse glandular pathologies coexist with high‐grade squamous intraepithelial lesion in cyto‐histological review of atypical glandular cells on ThinPrep specimens

Cited by 22 publications

References 16 publications

Clinical Significance of Atypical Glandular Cells in the Bethesda System 2001: A Comparison with the Histopathological Diagnosis of Surgically Resected Specimens

Clinical Significance of Atypical Glandular Cells in the Bethesda System 2001: A Comparison with the Histopathological Diagnosis of Surgically Resected Specimens

Papanicolaou tests with coexisting squamous and glandular abnormalities

Similar immunogenetics of Barrett’s oesophagus and cervical neoplasia: is HPV the common denominator?

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