The effect of embryo quality on subsequent pregnancy rates after in vitro fertilization

Erenus, Mithat; Zouves, Christo; Rajamahendran, P.; Leung, Susanne; Fluker, Margo R.; Gomel, Victor

doi:10.1016/s0015-0282(16)54603-2

Cited by 109 publications

(48 citation statements)

References 10 publications

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“…The descriptions for each cate gory are clearly defined. In addition, this method is no more subjective than other very popular methods of grad ing the embryos (performing the visual assessment and combining the parameters into one index) that are used in many laboratories [1][2][3][4][5][6][7][8]. Grading the parameters individ ually allows this method to be more objective than the previously described alternative.…”

Section: Discussionmentioning

confidence: 99%

“…Other methods developed are based on a numerical grading system that characterizes the blastomeres and the fragments in one combined grade [1][2][3][4][5][6][7][8]. Though they lack the detail of the aforementioned methods, they can be performed quickly and easily in the laboratory.…”

Section: Discussionmentioning

confidence: 99%

“…The typically low im plantation rate (generally <10%) has been attributed to factors inherent in the oocytes and preembryos or to the inadequate culture conditions [1][2][3][4]. It is thought that the 1 -equal, regular cells, no fragments; grade 2 -equal blastomeres and <20% fragmentation; grade 3 -unequal blastomeres, no fragmentation, and grade 4 -unequal blastomeres and >20% fragmentation [6], If the two grades are combined into one, a poor grade in either category results in an overall poor grade.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a New Embryo-Grading System to Predict Pregnancy Rates following in vitro Fertilization

Hoover

Baker²,

Jh³

et al. 1995

Gynecol Obstet Invest

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This study examines two descriptive parameters of embryo morphology to determine if either parameter correlates with subsequent pregnancy rates (PRs). The two parameters were the evenness (similarity in size) of the blas-tomeres and the degree of cellular fragmentation. A total of 242 embryo transfers in which 4 embryos were transferred were included. Sixty-nine (28.5%) clinical and 62 (25.6%) viable pregnancies resulted. In all cases 4 embryos were transferred, but the number of embryos with even round blastomeres (grade 1) varied from 0 to 4. Statistically, there was no correlation between PR and number of grade 1 embryos transferred. When 4 grade 1 embryos were transferred, the PR was 33.3 versus 28.1% when no grade 1 embryos were transferred. There was, however, a statistical difference in the implantation rate; a higher frequency of multiple gestations occurred when 3 or 4 of the embryos transferred were graded 1:12.7 as compared with 6.7% when < 2 embryos were grade 1. The significance of the degree of cellular fragmentation in the embryos was also assessed. There was no statistical difference in the PR according to the number (0–4) of embryos transferred that did not have fragments (grade A). When 4 grade A embryos were transferred, the PR was 18.2 versus 26.1 % when there were no grade A embryos. Neither implantation nor multiple-birth rates correlated with fragmentation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a New Embryo-Grading System to Predict Pregnancy Rates following in vitro Fertilization

Hoover

Baker²,

Jh³

et al. 1995

Gynecol Obstet Invest

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“…Fragmented embryos have a limited developmental potential and rarely result in implantation (115,116). Such abnormal embryo development has been reported to be due to inadequate culture environment.…”

Section: Reactive Oxygen Species In Human Embryosmentioning

confidence: 99%

Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,276

909

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Objective: To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction. Design: Review of literature. Setting: Fertility research center and obstetrics and gynecology department in a tertiary care facility. Result(s): ROS plays an essential role in the pathogenesis of many reproductive processes. In male-factor infertility, oxidative stress attacks the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus. Reactive oxygen species induced DNA damage may accelerate the process of germ cell apoptosis, leading to the decline in sperm counts associated with male infertility. ROS mediated female fertility disorders share many pathogenic similarities with the ones on the male side. These similarities include a potential role in the pathophysiology of endometriosis and unexplained infertility. High follicular fluid ROS levels are associated with negative IVF outcomes, particularly in smokers. Moreover, oxidative stress may be responsible in hydrosalpingeal fluid mediated embryotoxicity as well as poor in vitro embryonic development. Conclusion(s):High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states. (Fertil Steril 2003;79:829 -43.

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“…The most commonly used embryo assessment technique is cell number and morphological appearance of the embryo on the day of transfer (Erenus et al, 1991;Steer et al, 1992). It has been proposed that characteristics of the 2PN zygote can be used to predict viability (Tesarik and Greco, 1999;Scott et al, 2000;Balaban et al, 2001;Montag and van der Ven, 2001).…”

Section: Introductionmentioning

confidence: 99%

Sequential assessment of individually cultured human embryos as an indicator of subsequent good quality blastocyst development

Neuber¹

2003

Human Reproduction

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The effect of embryo quality on subsequent pregnancy rates after in vitro fertilization

Cited by 109 publications

References 10 publications

Evaluation of a New Embryo-Grading System to Predict Pregnancy Rates following in vitro Fertilization

Evaluation of a New Embryo-Grading System to Predict Pregnancy Rates following in vitro Fertilization

Role of reactive oxygen species in the pathophysiology of human reproduction

Sequential assessment of individually cultured human embryos as an indicator of subsequent good quality blastocyst development

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