The effect of ellagic acid on caspase-3/bcl-2/Nrf-2/NF-kB/TNF-α /COX-2 gene expression product apoptosis pathway: a new approach for muscle damage therapy

Aslan, Abdullah Nabi; Beyaz, Seda; Gök, Özlem; Erman, Orhan

doi:10.1007/s11033-020-05340-7

Cited by 29 publications

(12 citation statements)

References 40 publications

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“…Moreover, it downregulated malondialdehyde (MDA), NF-κB, TNF-α, and cyclooxygenase-2 (COX-2) and upregulated antioxidant enzymes (catalase and glutathione [GSH]), together with its transcriptional factor nuclear factor erythroid 2-related factor 2 (Nrf2). Furthermore, suppressing B-cell lymphoma 2 (bcl-2) and inducing caspase-3 led the damaged tissues to apoptosis [ 32 ]. It has also been shown to improve muscle dysfunction in cuprizone-induced demyelinated mice by imparting mitochondrial protection, oxidative stress prevention, and Sirt3 overexpression [ 33 ].…”

Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

“…Mainly, the E3 ubiquitin ligases atrogin-1, MuRF-1, and/Cbl-b were suppressed by PPs in muscle atrophies caused by inflammation, oxidative stress, and mitochondrial damage. The upstream regulators of E3 ubiquitin ligases, i.e., TNF-α, IL-6, IL-1β, NF-κB, myostatin, and FoxOs, were significantly suppressed by PPs [ 32 , 38 , 79 , 96 , 127 , 142 , 151 ]. Moreover, PPs modulated the expression of miRNAs associated with muscle atrophy.…”

Section: Critical Overview and Future Perspectivesmentioning

confidence: 99%

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Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies.

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Section: Polyphenols In Managing Muscle Atrophy and Muscle Healthmentioning

confidence: 99%

Section: Critical Overview and Future Perspectivesmentioning

confidence: 99%

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

2021

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“…They stated that adding pine needles and vitamin E to female Japanese quail feed increases improved female quail performance and serum antioxidant system. Aslan et al [41], investigated the protective role of EA against muscle damage in CCl4-induced rats. Compared to CCl4 group, they revealed that in EA given groups, GSH level increased while MDA levels decreased.…”

Section: Discussionmentioning

confidence: 99%

Biological and Oxidative Effect of Ellagic Acid on Saccharomyces cerevisiae: A New Way for Culture Developing

Gök

Beyaz

Aslan

2021

Braz. arch. biol. technol.

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In this study, the effects of Ellagic acid (EA) on protein expression in yeasts and cellular development were investigated. Four groups were formed. Groups: 1) Control group; yeast only cultivated group; 2) Ellagic Acid (EA) group: EA (10%) given group; 3) Hydrogen peroxide (H2O2) Group: The group given H2O2 (15 mM); 4) EA + H2O2 group: EA (10%) + H2O2 (15 mM) group. After sterilization, EA (10%) and H2O2 (15 mM) were added to the Saccharomyces cerevisiae (S. cerevisiae) cultures and the cultures were grown at 30 °C for 1 hour, 3 hours, 5 hours and 24 hours (overnight). S. cerevisiae cell growth, lipid peroxidation MDA (malondialdehyde) analysis and GSH (glutathione) level were analyzed by spectrophotometer. Total protein changes were determined by SDS-PAGE electrophoresis and measured by the Bradford method. According to the obtained results, compared with the H2O2 group, cell development (1, 3, 5 and 24 hours), GSH level and total protein synthesis (24 hours) were increased with EA, while MDA level (24 hours) decreased. These results show that EA reduces oxidative damage, increases cell growth and it has a protective effect to promote protein synthesis in S. cerevisiae culture.

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“…Usually Interleukin 1 is responsible for producing in ammation as well as promoting fever and sepsis. IL-1α is produced by activated macrophages as well as neutrophils, epithelial cells and endothelial cells (Tilg and Moschen 2006;Feng et al 2011;Aslan and Can 2014;Pekmezsi et al 2018;Aslan et al 2020b;Aslan et al 2020c).…”

Section: Introductionmentioning

confidence: 99%

The inducing of caspase and bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

Aslan

Can

Gök

et al. 2021

Preprint

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In this study, 42 Wistar albino female rats (n = 42, 8 weeks old) were used. Rats were divided into 6 groups and 7 rats included each group. Groups: (i) Control Group: Standard diet; (ii) RJ (royal jelly) Group: Standard diet + royal jelly; (iii) F50 Group: Standard diet + 50 mg/kg fluoride; (iv): F100 Group: Standard diet + 100 mg/kg fluoride; (v) F50 + RJ Group: Standard diet + 50 mg/kg fluoride + royal jelly; (iv): F100 + RJ Group: Standard diet + 100 mg/kg fluoride + royal jelly. After the 8-week study period, the rats were decapitated and their muscle tissues were removed. Expression levels of Caspase-3, Caspase-6, Bax, Tnf-α, IL1-α and Bcl-2 proteins in muscle tissue were determined by Western Blotting method. Histopathological analyzes were also performed on the muscle tissue. MDA, GSH, and CAT analyzes were determined by spectrophotometric analysis. According to our findings, Bcl-2, Tnf-α and IL1-α protein expression were increased in damage groups compared to control and royal jelly groups, Caspase-3, Caspase-6 and Bax protein expression levels decreased in damage groups. There was an increase in MDA level in damage groups compared to the control and royal jelly groups, CAT and GSH levels decreased in damage groups. According to histopathological analysis results, edema and inflammatory cell formations were found in the injury groups, a tendency to decrease in these injuries was observed in the treatment groups. Based on these results, we can say that royal jelly has protective effects against fluoride damage.

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The effect of ellagic acid on caspase-3/bcl-2/Nrf-2/NF-kB/TNF-α /COX-2 gene expression product apoptosis pathway: a new approach for muscle damage therapy

Cited by 29 publications

References 40 publications

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health

Biological and Oxidative Effect of Ellagic Acid on Saccharomyces cerevisiae: A New Way for Culture Developing

The inducing of caspase and bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats

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