Biological and Oxidative Effect of Ellagic Acid on Saccharomyces cerevisiae: A New Way for Culture Developing

Gök, Özlem; Beyaz, Seda; Aslan, Abdullah Nabi

doi:10.1590/1678-4324-2021210002

Cited by 7 publications

(1 citation statement)

References 34 publications

(36 reference statements)

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“…Similarly, Beyaz et al (2021b) found out that EGCG treatment showed biological activities such as antioxidant, antimicrobial and antiinflammatory. Gok et al (2021b) stated that ellagic acid reduces oxidative damage in yeasts, increases cell growth, and has a protective effect by promoting protein synthesis.…”

Section: Discussionmentioning

confidence: 99%

A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf

Beyaz

Gök

Aslan

2022

International Journal of Secondary Metabolite

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Olive tree (Olea europaea L.) leaf is known to have a number of bioactive properties being antioxidant, antihypertensive, antiatherogenic, anti-inflammatory, antifungal, antiviral and antimicrobial. In this study, the immunomodulatory roles of Olive tree (Olea europaea L.) leaf against oxidative damage caused by carbon tetrachloride (CCl4) in Saccharomyces cerevisiae were investigated. In the study, four groups were formed; namely, (i) Control Group: Yeast only planted group; (ii) CCl4 Group: Group given CCl4 (15 mM); (iii) Olive Tree Leaf Group: The group given olive tree leaf (10%); and (iv) Olive Tree Leaf + CCl4 Group: Olive tree leaf (10%) + CCl4 (15 mM) given group. Cultures of Saccharomyces cerevisiae were grown at 30 °C for 1, 3, 5, and 24 hours. Malondialdehyde (MDA), glutathione levels (GSH), cell growth and catalase (CAT) activity measurements were determined by spectrophotometer. Total protein concentrations were determined by SDS-PAGE electrophoresis and the Bradford protein method. According to the results obtained; compared to the CCl4 group, cell growth (1, 3, 5 and 24 hours), total protein synthesis, and GSH and CAT activities (24 hours) increased in olive tree leaf groups, while MDA level (24 hours) decreased. Thanks to its strong bioactive properties, olive tree leaf has been found to increase cell growth and total protein synthesis by decreasing CCl4 induced oxidative stress in Saccharomyces cerevisiae culture. It has been concluded that if the olive tree leaf is used regularly, it will be beneficial in eliminating many health problems.

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Section: Discussionmentioning

confidence: 99%

A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf

Beyaz

Gök

Aslan

2022

International Journal of Secondary Metabolite

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Study of the effect of calcium signal participating in the antioxidant mechanism of yeast under high‐sugar environment

Xie,

Sun,

et al. 2024

J Sci Food Agric

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BackgroundSaccharomyces cerevisiae is susceptible to high sugar stress in production of bioethanol, wine and bread. Calcium signal is widely involved in various physiological and metabolic activities of cells, the present study aimed to explore effects of Ca2+ signal on the antioxidant mechanism of yeast during high sugar fermentation.ResultsCompare to yeast without avaibale Ca2+, yeast in high glucose with Ca2+ group had higher dry weight, higher ethanol output at 12 h and 24 h, higher glycerol output at 24 and 36 h. During the whole growth process, the trehalose synthesis capacity of yeast in high glucose with Ca2+ group was lower and intracellular ROS content was higher compared to yeast without avaibale Ca2+. Intracellular malondialdehyde content of yeast under high glucose with Ca2+ was significantly lower than yeast in high glucose without available Ca2+ except for 6 h. The superoxide dismutase, catalase activities of yeast and glutathione content were higer in high glucose group with Ca2+ compared to yeast in high glucose without avaibale Ca2+. The expression level of SOD1, GSH1, GPX2 genes were higher in high glucose without available Ca2+ at 6 h, while yeast in high glucose with Ca2+ group had a higher expression of antioxidant‐related genes except SOD1 and CTT1 at 12 h, whole antioxidant‐related genes of yeast in high glucose with Ca2+ were higher at 24 h, and the genes except SOD1 of yeast in high glucose with Ca2+ were higher at 36 h.ConclusionHigh glucose stress limited the growth of yeast, while the moderate extracellular Ca2+ signal could improve the antioxidant capacity of yeast in a high glucose environment by regulating protectants metabolism, enhancing the antioxidant enzyme activity and expression of antioxidant genes in high sugar environment.This article is protected by copyright. All rights reserved.

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Royal jelly regulates the caspase, Bax and COX-2, TNF-α protein pathways in the fluoride exposed lung damage in rats

et al. 2022

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Biological and Oxidative Effect of Ellagic Acid on Saccharomyces cerevisiae: A New Way for Culture Developing

Cited by 7 publications

References 34 publications

A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf

A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf

Study of the effect of calcium signal participating in the antioxidant mechanism of yeast under high‐sugar environment

Royal jelly regulates the caspase, Bax and COX-2, TNF-α protein pathways in the fluoride exposed lung damage in rats

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