The Effect of Elevated Triglycerides on the Onset and Progression of Coronary Artery Disease: A Retrospective Chart Review

Abstract

Background. The American College of Cardiology and American Heart Association did not indicate a correlation between treating hypertriglyceridemia and reducing cardiovascular events. Objective. This study investigated whether patients with hypertriglyceridemia were more prone to worse outcomes during cardiac catheterization. Methods. Data collected over a one-year period analyzed lipid panels obtained at the time of cardiac catheterization. Triglyceride levels were categorized into three groups: <150 mg/dL, 150 mg/dL–300 mg/dL, and >300 mg/dL. Controlled variables included age, gender, the presence of hypertension, diabetes, hyperlipidemia, and history of coronary artery disease. Results. Subjects with a triglyceride level <150 mg/dL have a 54% likelihood of being treated medically compared to 38% and 41% in the 150 mg/dL–300 mg/dL and >300 mg/dL groups, respectively (p < 0.01). Subjects with a triglyceride level >300 mg/dL have a 20% percent chance of being treated with a coronary artery bypass graft compared to 12% and 15% in the <150 mg/dL and 150 mg/dL–300 mg/dL groups, respectively (p < 0.01). Subjects with a triglyceride level between 150 and 300 mg/dL have a 44% percent of being treated with a percutaneous coronary intervention compared to 34% and 43% in the <150 mg/dL and >300 mg/dL groups, respectively (p < 0.01). Conclusion. Hypertriglyceridemia was associated with worse outcomes in percutaneous coronary intervention or surgery.

Study the Effectiveness of (G-6-PhD) Enzyme and the Level of Fats in People with Leukemia

“…There is a decrease in HDL levels of people with leukemia and with age. These results are consistent with [24] and have the highest rate of increase in the last age group-(46-60) years old and the cause of the severity and aggravation of the disease by increasing age [25] . The cause of low levels of (HDL) may be due to the vital use of (HDL) by cancer cells in the process of building and multiplying cancer cells in the body [27] ,or maybe due to the low efficacy of the enzyme (Lipoprotein lipase) which is responsible for the analysis of triglycerides to fatty acids and glycerol and therefore the degradation of molecules (V-LDL), which lead to the depletion of HDL molecules by blocking the transfer of all lipid and (Apo protein) from ( lipoprotein ) which is rich in tripartite triglycerides to HDL and also inhibit the exchange between ester and colicetrol in (HDL) and (TG) in (VLDL) [28] .…”

“…Moreover, this is consistent with previous studies of researchers [23][24] , which recorded the highest rate of increase in the last age (46 -60) year old. This might be attributed to the severity and the aggravation of the disease to increase the age [25] .…”