The effect of EDTA, EGTA, EDTAC, and tetracycline-HCl with and without subsequent NaOCl treatment on the microhardness of root canal dentin

Sayın, Taner Cem; Serper, Ahmet; Çehrelį, Zafer C.; Otlu, Harika

doi:10.1016/j.tripleo.2007.03.021

Cited by 102 publications

(138 citation statements)

References 43 publications

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“…Nevertheless, this association leads to dentinal tubule orifice opening, intertubular dentinal erosion (12,20) and dentin microhardness reduction (21). When NaOCl was used alone as an irrigating agent, the exposed inorganic material prevented further dissolution of dentine.…”

Section: Discussionmentioning

confidence: 99%

Intracanal Irrigating Solutions Prior to Calcium Hydroxide Medication and Its Effects on Root Dentin Strength

et al. 2017

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The aim of this study was to assess the effects of intracanal irrigation with sodium hypochlorite (NaOCl) and ethylenediaminetetracetic acid (EDTA) prior to calcium hydroxide medication on the compressive strength of root dentin. Forty-eight roots with single and straight canals were instrumented with a crown-down technique using Flexofile files and Gates Glidden burs, under 0.9% sodium chloride (NaCl) irrigation. Root canals were randomly separated into 4 groups (n=12), according to the irrigating solution: Control Group, 0.9% NaCl; Group NaOCl , 1% NaOCl; Group EDTA , 17% EDTA; and Group EDTA+NaOCl , 17% EDTA and 1% NaOCl. Solutions remained for 40 min, renewed every 10 min, except for Group EDTA+NaOCl , where the solutions were alternated every 10 min. Canals were dried and filled with calcium hydroxide paste, and radiographed. Each canal was sealed and stored at 37 °C for 30 days. After this period, the roots were cut 1 mm below the cementoenamel junction and 6 mm apically from this point in order to obtain 6 mm-long cylinders. The compressive test was conducted with a crosshead speed of 1 mm/min. The means (±SD) (MPa) of compressive strength were: Control Group, 151.23±94.36; Group NaOCl , 167.50±57.25; Group EDTA , 108.79±99.88; Group EDTA+NaOCl , 60.12±92.10. Significant statistical differences among groups were found (ANOVA and Tukey, α=5%, p=0.02). Control Group and Group NaOCl showed higher means of compressive strength than Group EDTA+NaOCl . Intracanal irrigation with 17% EDTA and 1% NaOCl produced a significant reduction of dentin compressive strength 30 days after medication with calcium hydroxide.

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Section: Discussionmentioning

confidence: 99%

Intracanal Irrigating Solutions Prior to Calcium Hydroxide Medication and Its Effects on Root Dentin Strength

et al. 2017

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“…It has been known for some time that varying concentrations of chelating agents, such as EDTA, acids, and disinfecting agents such as sodium hypochlorite (NaOCl), have demonstrated an ability to undermine dentin microhardness and elasticity (60)(61)(62)(63), while a more recent study has reported that dentin subject to prolonged calcium hydroxide (CaOH) exposure, demonstrates a decreased resistance to fracture (162).…”

Section: Discussionmentioning

confidence: 99%

“…Structural changes in dentin as a result of chemicals used for endodontic irrigation have been extensively studied in the literature (9,10,(59)(60)(61)(62). Changes in the organic and inorganic components of dentin will affect the mechanical properties of dentin.…”

Section: Ultrastructural Changes To Dentin Following Iatrogenic Procementioning

confidence: 99%

“…Changes in the organic and inorganic components of dentin will affect the mechanical properties of dentin. Various concentrations of chelating agents, including ethylenediaminetetraacetic acid (EDTA) and citric acid, can reduce dentin microhardness (60,61,63). Sodium hypochlorite (NaOCl) is the most commonly used endodontic antimicrobial irrigant, which has the ability to dissolve the organic material.…”

Section: Ultrastructural Changes To Dentin Following Iatrogenic Procementioning

confidence: 99%

“…The use of 5.25% NaOCl has been reported to decrease Young's modulus of dentin, in addition to its flexural stress (62). Reduction in dentin elasticity after treatment with NaOCl has also been reported (60,61,63). This may be due to the dissolution of the organic component of the dentin by NaOCl.…”

Section: Ultrastructural Changes To Dentin Following Iatrogenic Procementioning

confidence: 99%

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Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Persadmehr

Torneck

Cvitkovitch

et al. 2014

Journal of Endodontics

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This study evaluated the ability of photodynamic therapy (PDT), chitosan nanoparticles (CSnp), or their combination, to inhibit bacterial collagenase-mediated degradation of collagen. Rat type 1 fibrillar collagen matrices were untreated or treated with 2.5% glutaraldehyde (GD), 2.5% GD followed by 1% CSnp, 1% CSnp, PDT, or 1% CSnp followed by PDT. Samples, except untreated controls, were exposed to Clostridium histolyticum collagenase. The soluble digestion products were assessed by hydroxyproline assay and the remaining adherent collagen was quantified by picrosirius red (PSR) staining. Collagen treated with CSnp, PDT, or a combination of CSnp and PDT, exhibited less degradation than controls. The abundance of post-treatment residual collagen correlated with the extent of degradation. Fourier transform infrared (FTIR) spectroscopy analysis showed that PDT treatment enhanced collagen cross-linking.Immunoblotting of sedimented CSnp indicated that CSnp and collagenase bound with low affinity. However, CSnp-bound collagenase showed a significant reduction in collagenolytic activity compared with controls.III

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Effects of chemical agents on physical properties and structure of primary pulp chamber dentin

Pascon

Kantovitz

Gaspar

et al. 2013

Microscopy Res & Technique

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This study evaluated the effects of chemical agents on the physical properties and structure of primary pulp chamber dentin using surface roughness, microhardness tests, and scanning electron microscopy (SEM). Twenty-five primary teeth were sectioned exposing the pulp chamber and were divided into five groups (n = 5): NT, no treatment; SH1, 1% sodium hypochlorite (NaOCl); SH1U, 1% NaOCl + Endo-PTC®; SH1E, 1% NaOCl + 17% EDTA; and E, 17% EDTA. After dentin treatment, the specimens were submitted to roughness, microhardness testing, and SEM analysis. Roughness and microhardness data were submitted to one-way ANOVA and Tukey's test (P < 0.05). The SH1E group showed the highest roughness, followed by the E group (P < 0.05) when compared with the NT, SH1, and SH1U groups. Microhardness values of SH1 and SH1U showed no significant difference as compared to the NT (control) group (P > 0.05). Microhardness values could not be obtained in the EDTA groups (SH1E and E). The presence of intertubular dentin with opened dentin tubules was observed in the NT, SH1, and SH1U groups. SH1E showed eroded and disorganized dentin with few opened tubules and the intertubular/peritubular dentin was partially removed. Considering the physical and structural approaches and the chemical agents studied, it can be concluded that NaOCl and NaOCl associated with Endo-PTC® were the agents that promoted the smallest changes in surface roughness, microhardness, and structure of the pulp chamber dentin of primary teeth.

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The effect of EDTA, EGTA, EDTAC, and tetracycline-HCl with and without subsequent NaOCl treatment on the microhardness of root canal dentin

Cited by 102 publications

References 43 publications

Intracanal Irrigating Solutions Prior to Calcium Hydroxide Medication and Its Effects on Root Dentin Strength

Intracanal Irrigating Solutions Prior to Calcium Hydroxide Medication and Its Effects on Root Dentin Strength

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Effects of chemical agents on physical properties and structure of primary pulp chamber dentin

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