The effect of edaravone on ischemia–reperfusion injury in rat ovary

Kara, Mustafa; Dağlıoğlu, Yusuf Kenan; Kuyucu, Yurdun; Tuli, Abdullah; Tap, Özgül

doi:10.1016/j.ejogrb.2012.02.026

Cited by 30 publications

(26 citation statements)

References 19 publications

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“…SOD, CAT, GPx and GST activities are increased to prevent ovarian tissue injury. These enzymatic systems localized in cellular membranes are the most important means to protect the tissue against injuries (Gupta et al 2006;Sasaki and Joh 2007;Kara et al 2012). But, when the cells are exposed to highly elevated oxidative stress the antioxidant mechanism could be damaged leading to decreased antioxidant enzyme activities and their gene expressions (Rodriguez et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Pandır

Kara

2013

Cytotechnology

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Cisplatin is one of the most effective chemotherapeutic agents but injury may occur at higher doses. The aim of this study was to investigate the effect of bilberry on cisplatin induced toxic effects in rat ovary. Twenty-one female Wistar-Albino rats were utilized to form three groups: In group 1 (control group), each rat received intraperitoneal injection of 1 mL of 0.9 % NaCl saline solution during 10

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Section: Discussionmentioning

confidence: 99%

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Pandır

Kara

2013

Cytotechnology

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“…Many substances have been found to reduce reperfusion injury after surgical treatment. These include agents that increase blood flow, such as iloprost, as well as radical cleansing agents such as edaravone (15,16). Some substances act directly by inactivating reactive oxygen radicals (17,18).…”

Section: Discussionmentioning

confidence: 99%

Effect of Doxycycline on Aseptic Reperfusion Injury in Ovarian Torsion

Bektas

Karasu

Yurtcu

et al. 2019

Gynecol Obstet Reprod Med

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OBJECTIVE: Reperfusion injury occurs when the condition causing ischemia in ovarian torsion is corrected and the blood supply is re-established. The aim of this study is to evaluate whether doxycycline treatment reduces reperfusion injury in a rat model. STUDY DESIGN:Thirty-five female albino Wistar rats were split into the five groups. Sham: Sham operation; ischemia (I): 2 hours of ischemia; ischemia and reperfusion (I/R): 2 hours of ischemia followed by 2 hours of reperfusion; Sham-Dc: Sham operation and doxycycline 10-mg/kg (2 hours prior to surgery); I/R-Dc: 2-hours of ischemia and doxycycline 10-mg/kg and 2-hours of reperfusion. The groups were compared in terms of histological and biochemical features. A semi-quantitative histological assessment scoring system was used for the histological examination. Follicular cell degeneration, vascular congestion, haemorrhage, and inflammatory cell count were evaluated for histological analysis. For biochemical analysis of reperfusion injury, the body's total antioxidant status and total oxidant status were measured using a fully automatic method. The oxidative stress index was calculated by dividing total antioxidant status by total oxidant status. RESULTS:In the sham group the ovaries were histologically normal. Oedema, vascular congestion, bleeding, leukocyte infiltration, and follicle degeneration were increased in other groups (p<0.05). There was less leukocyte infiltration in the I/R-Dc group compared to I/R group. Other histological features were similar in these groups. Doxycycline increased the malondialdehyde, total antioxidant and total oxidant status levels in Sham-Dc and I/R-Dc groups. This increase was statistically significant between Sham and Sham-Dc groups. However, although there was an increase in the biochemical markers in the I/R-Dc group, this increase was not significant compared to I/R group. CONCLUSION: Doxycycline treatment in ovarian torsion does not reduce I/R injury. Doxycycline may even increase reperfusion injury, according to biochemical findings.

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“…In these cases ischemic damage lead to the formation of more tissue damage. 16,18,20 Therefore, in order to avoid I/R damage the use of antioxidant pharmacological agents may be useful during or before reperfusion. 20 In studies Dexmedetomidine has been shown to be useful in intestinal, testicular, kidney, lung and cardiac I/R injury.…”

Section: Discussionmentioning

confidence: 99%

“…The scoring system was used based from a previous study, Kara et al were described in 2012. 16 The analysis on the ovarian sections was conducted in a blinded fashion by the same pathologist.…”

Section: Histological Evaluationmentioning

confidence: 99%

Protective Effects of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Ovary

Kirazoğlu¹,

Uyanıkoğlu²,

Incebiyik³

2017

Turkiye Klinikleri J Lab Anim

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dnexal torsion is the fifth leading cause of emergency gynecological surgery in spite of being seen rare. It is often seen in women with reproductive age, although it can be seen in prepubertal and postmenopausal period.1 Early diagnosis and treatment plays an important role in maintain the fertilization. Laparoscopy is a precise diagnosis and treatTurkiye Klinikleri J Lab Anim 2017;1(2):71-7 71Protective Effects of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Ovary A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Aim of this study is to evaluate the protective effect of dexmedetomidine on the histopathology and biochemical parameters in reducing damage in ischemia/reperfusion injury in rats ovary and to compare the effect of two different doses of dexmedetomidine. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty-two adult female Wistar Albino rats were used. Rats were separated into six groups: Sham, Torsion, Torsion+Detorsion, Torsion+Detorsion+Salin, Torsion+Detorsion+ Dexmedetomidine 10 µg/kg, and Torsion+Detorsion+Dexmedetomidine 20 µg/kg. Exception of the Sham group, ovarian torsion procedure was performed to all groups for 2 hours. Detorsion procedure was implemented to all groups for 2 hours, exception of Torsion group. Medications were given intraperitoneally half an hour before the detorsion procedure in Salin, Dexmedetomidine 10 µg and 20 µg groups. Then 2 mL of blood samples were drawn for markers of oxidative stress. The right ovaries were separated from all rats. R Re es su ul lt ts s: : The oxidative stress levels and histologic scores values of ovarian tissues were higher in Torsion+Detorsion group than in Sham group (p<0.001). By the uses of dexmedetomidine 10 and 20 µg, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores. C Co on nc cl lu us si io on n: : Administration of dexmedetomidine 10 µg and 20 µg are effective in preventing tissue damage by ischemia\reperfusion injury in ovarian torsion. However, there was no difference between the dexmedetomidine 10 µg and 20 µg treatments with regards to protective activity. K Ke ey yw wo or rd ds s: : Ovary; dexmedetomidine; reperfusion injury Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı rat overlerinde deneysel olarak oluşturulan iskemi\reperfüzyon hasarına karşı deksmedetomidin tedavisinin koruyucu etkinliğini değerlendirmek ve iki farklı deksmedetomidin dozlarını karşılaştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmada 42 tane dişi Wistar Albino rat kullanıldı. Ratlar her biri yedişer rat olmak üzere 6 gruba ayrıldı: Sham opere, Torsiyon, Torsiyon-Detorsiyon, Torsiyon+Detorsiyon+ İzotonik sodyum klorür, Torsiyon-Detorsiyon+ Deksmedetomidin 10 µg ve Torsiyon-Detorsiyon+ Deksmedetomidin 20 µg. Sham opere grubu hariç diğer tüm gruplara iki saat boyunca ovaryan torsiyon işlemi uygulandı. Torsiyon grubu dışındaki diğer tüm gruplara 2 saat detorsiyon prosedürü uygulandı. Salin, Deksmedetomidin 10 µg ve Deksmedetomidin 20 µg gruplarında y...

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The effect of edaravone on ischemia–reperfusion injury in rat ovary

Cited by 30 publications

References 19 publications

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Protective effect of bilberry (Vaccinium myrtillus L.) on cisplatin induced ovarian damage in rat

Effect of Doxycycline on Aseptic Reperfusion Injury in Ovarian Torsion

Protective Effects of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Ovary

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