The effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease

Tandra, Swetha; Kandadai, Rukmini Mridula; Peddisetty, Ravi P; Babu, KamaniNaresh; Prabha, T. Surya; Jabeen, Shaik Afshan; Meena, A K; Borgohain, Rupam

doi:10.4103/aian.aian_11_19

Cited by 3 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are very few studies assessing various frequencies for improvement in gait and reassessing the patients on long-term follow-up. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

Changes in Optimal Stimulation Frequency with Time for Gait Disturbances in Patients with PD after STN-DBS—A Longitudinal Study

Kola,

Rangam,

Kandadai

et al. 2023

Annals of Indian Academy of Neurology

Self Cite

View full text Add to dashboard Cite

Aim: To assess the changes in frequency parameters of STN-DBS stimulation over 6 months required to optimize gait in PD patients. Methods: It’s a single center, open label longitudinal study of PD patients after STN-DBS with gait disorders. Gait assessment using stand–walk–sit (SWS) test and freezing of gait (FOG) scores were done at baseline and after 6 months. Gait was assessed in five frequencies settings, that is, 60 Hz, 90 Hz, 130 Hz, 180 Hz and stimulation “OFF” during medication ON state. Voltage was maintained. Results: Fifteen post-deep brain stimulation (DBS) patients were included. Mean duration after surgery was 3.73 ± 2.82 years. In SWS and FOG at baseline, five patients have good response at 180 Hz frequency, five at 130 Hz, one at 90 Hz, two patients at 60 Hz, one both 60 and 90 Hz, and one at both 90 and 180 HZ. And after 6 months out of the 13 patients who were able to perform the test, four patients had good response at 180 Hz frequency, four at 130 Hz, two at 90 Hz, one each for 60 Hz and battery OFF state, and one for both 130 Hz and 180 Hz. At 6 months, four patients had good response at the same frequency as baseline, while 11 patients have change in frequency from baseline. Conclusion: Optimal frequency for gait varies in patients—both low and high frequency may be useful. Optimal frequency for improving gait changes over period of time. Regular assessment and changing frequency may improve gait after DBS.

show abstract

“…There are very few studies assessing various frequencies for improvement in gait and reassessing the patients on long-term follow-up. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

Changes in Optimal Stimulation Frequency with Time for Gait Disturbances in Patients with PD after STN-DBS—A Longitudinal Study

Kola,

Rangam,

Kandadai

et al. 2023

Annals of Indian Academy of Neurology

Self Cite

View full text Add to dashboard Cite

show abstract

Optimal subthalamic stimulation sites and related networks for freezing of gait in Parkinson’s disease

Fan,

Guo,

Jiang

et al. 2023

Brain Communications

View full text Add to dashboard Cite

Freezing of gait is a common and debilitating symptom in Parkinson’s disease. Although high-frequency subthalamic deep brain stimulation is an effective treatment for Parkinson’s disease, post-operative freezing of gait severity has been reported to alleviate, deteriorate or remain constant. We conducted this study to explore the optimal stimulation sites and related connectivity networks for high-frequency subthalamic deep brain stimulation treating freezing of gait in Parkinson’s disease. A total of 76 Parkinson’s disease patients with freezing of gait who underwent bilateral high-frequency subthalamic stimulation were retrospectively included. The volumes of tissue activated were estimated based on individual electrode reconstruction. The optimal and sour stimulation sites were calculated at coordinate/voxel/mapping level and mapped to anatomical space based on patient-specific images and stimulation settings. The structural and functional predictive connectivity networks for the change of the post-operative Freezing of Gait-Questionnaire were also identified based on normative connectomes derived from the Parkinson’s Progression Marker Initiative database. Leave-one-out cross-validation model validated the above results, and the model remained significant after including covariates. The dorsolateral two-thirds of the subthalamic nucleus was identified as the optimal stimulation site, while the ventrocentral portion of the right subthalamic nucleus and internal capsule surrounding the left central subthalamic nucleus were considered as the sour stimulation sites. Modulation of the fibre tracts connecting to the supplementary motor area, pre-supplementary motor area and pedunculopontine nucleus accounted for the alleviation of freezing of gait, whereas tracts connecting to medial and ventrolateral prefrontal cortices contributed to the deterioration of freezing of gait. The optimal/sour stimulation sites and structural/functional predictive connectivity networks for high-frequency subthalamic deep brain stimulation treating freezing of gait are identified and validated through sizable Parkinson’s disease patients in this study. With the growing understanding of stimulation sites and related networks, individualized deep brain stimulation treatment with directional leads will become an optimal choice for Parkinson’s disease patients with freezing of gait in the future.

show abstract

Letter Regarding the Article Entitled

Önder¹,

Çomoğlu²

2022

Annals of Indian Academy of Neurology

View full text Add to dashboard Cite

The effect of dual tasking and deep brain stimulation frequency parameters on gait in advanced Parkinson's disease

Cited by 3 publications

References 18 publications

Changes in Optimal Stimulation Frequency with Time for Gait Disturbances in Patients with PD after STN-DBS—A Longitudinal Study

Changes in Optimal Stimulation Frequency with Time for Gait Disturbances in Patients with PD after STN-DBS—A Longitudinal Study

Optimal subthalamic stimulation sites and related networks for freezing of gait in Parkinson’s disease

Letter Regarding the Article Entitled

Contact Info

Product

Resources

About