The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

Wang, Jinling; Ma, Wanli; Guo, Qiang; Liu, Ying; Hu, Zhongdong; Zhu, Zhixiang; Wang, Xiaohui; Zhao, Yunfang; Chai, Xingyun; Tu, Pengfei

doi:10.2147/ijn.s113882

Cited by 42 publications

(21 citation statements)

References 47 publications

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“…Total RNA was reverse transcribed and analyzed by qPCR as described previously. 27 β-actin was used as the control, and the data for each sample were expressed relative to the expression level of β-actin. The target genes with PepT1 and β-actin mRNA primers are as shown in Table 1.…”

Section: Quantitative Real-time Pcr (Qpcr)mentioning

confidence: 99%

Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption

Wang¹,

Wang²,

Liu³

et al. 2018

IJN

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IntroductionPolymeric micelles (PMs) hold promise for improving solubility and oral absorption of poorly soluble drugs. Unfortunately, the oral absorption of PMs is also limited by intestinal epithelium. To improve the oral delivery efficiency of micelles, transporter-mediated micelles could enhance the transport efficiency across the epithelial barrier, and they have attracted more attention.MethodsPeptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) onto the surface of curcumin (Cur)-loaded-D-α-tocopheryl polyethylene glycol 1000 succinate micelles (TP-PMs). The oral absorption mechanism and oral bioavailability were further investigated in vitro and in vivo.ResultsThe cellular study showed that Val-PMs/Phe-PMs had a high PepT1 affinity, resulting in a higher drug uptake and transcellular transport than TP-PMs. In rats, Val-PMs/Phe-PMs exhibited higher intestinal accumulation in the apical side of the intestinal epithelium than TP-PMs, promoting drug diffusion across epithelial barrier. The oral bioavailability of Cur was significantly improved by Val-PMs/Phe-PMs, which was about 10.50- and 3.40-fold greater than that of Cur-Sol and TP-PMs, respectively.ConclusionPepT-1-mediated micelles, using PepT1 as a target on intestinal epithelium, have unique functions with intestine and prove promising for oral delivery of poorly water-soluble drugs.

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Section: Quantitative Real-time Pcr (Qpcr)mentioning

confidence: 99%

Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption

Wang¹,

Wang²,

Liu³

et al. 2018

IJN

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“…The colloidal stability of HA/TPGS2k-PMs was evaluated in different FBS aqueous ( Figure 1(C,D )), which was nearly the same as that of HA-PMs and TPGS2k-PMs (Wang et al., 2016 ). The particle size of HA/TPGS2k-PMs was increased with the augment of incubation time and the concentration of FBS.…”

Section: Resultsmentioning

confidence: 68%

“…Cur was obtained from Sigma Aldrich (St. Louis, MO, USA). HA-g-VES (Wang et al., 2016 ) and PEG 2000 VES (TPGS2k) (Wang et al., 2012 ) was synthesized by our group. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2 H -tetrazolium bromide (MTT) and dimethyl sulphoxide (DMSO) of analytical reagent grade were obtained from Sigma-Aldrich Co. (St. Louis, MO, USA).…”

Section: Methodsmentioning

confidence: 99%

“…HA, a natural glycosaminoglycan, has been extensively applied as “magic targeting ligand” for anticancer drug delivery (Yadav et al., 2007 ; Datir et al., 2012 ; Gao et al., 2015 ). HA-based micelles are beneficial in chemotherapy due to the specifically targeting to the CD44 receptors, which are over-expressed on the tumor surface (Almalik et al., 2013 ; Wang et al., 2016 ). However, HA-based micelles are limited by the MPS clearance and short blood circulation after intravenous administration (Kim et al., 2013 ; Han et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo

et al. 2018

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Polyethylene glycol (PEG)-based block copolymer micelles and hyaluronic acid (HA)-based grafted copolymer micelles have been widely investigated in chemotherapy. In this study, to evaluate the differences among HA-based grafted polymer micelles, PEG-based block polymer micelles and the mixed of these two micelles in enhancing antitumor effects and overcoming MDR, two amphiphilic vitamin E succinate (VES) derivatives, HA VES (HA-g-VES) and PEG 2000 VES (TPGS2k), were applied as nanocarriers to prepare HA-VES micelles (HA-PMs), TPGS2k micelles (TPGS2k-PMs) and the mixed micelles (HA/TPGS2k-PMs) for the co-delivery of doxorubicin (DOX) and curcumin (Cur). With the addition of TPGS2k, the particle size of HA/TPGS2k-PMs (153.37 ± 1.00 nm) was smaller than that of HA-PMs (223.83 ± 1.84) but significantly larger than that of TPGS2k-PMs (about 20 nm). The loading efficiency of HA/TPGS2k-PMs was 7.10%, which was lower than HA-PMs (8.31 ± 0.15%) but higher than TPGS2k-PMs (4.38 ± 0.24%). In vitro, HA/TPGS2k-PMs and TPGS2k-PMs exhibited higher cytotoxicity and reversal MDR effects than HA-PMs in MCF-7/Adr cells. However, HA/TPGS2k-PMs, HA-PMs and TPGS2k-PMs all significantly improved the tumor biodistribution, the antitumor effects and reduced the side effects of DOX in 4T1-tumor-bearing mice, but these three micelles displayed no differences in vivo. Therefore, EPR passive targeting effects caused by PEGylated micelles and CD44 active targeting effects caused by HA-based micelles have no significant variance in the delivery of antitumor drugs by i.v.

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“…Fortunately, Maeda et al [45] designed the original polymer anti-tumour drug and successfully improved tumour accumulation of drugs via EPR effect-mediated passive targeting, which also opened the curtain of passive targeting of micelles in 1979. Moreover, strategies for actively targeting tumours by modified homing molecules such as ligands or antibody on PMs surfaces had also been widely reported due to active targeting was more accurate than passive targeting [46] (Figure 1).…”

Section: Passive and Active Targeting Are Applied For Intelligent Co-mentioning

confidence: 99%

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

Ning

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Polymeric micelles (PMs) play a vital role in multidrug co-delivery and cancer treatment. However, development of intelligent PMs further allows PMs to accurately target tumour, selectively release cargo multidrug and increase uptake. Therefore, targets, controlled release and uptake of intelligent PMs should be paid more attention to improvement of synergistic therapeutic outcomes and minimize side effects. In this review, tumour targeting of co-delivery intelligent PMs and its intracellular trafficking mechanisms were overviewed. And this review provides a comprehensive summarization of several intelligent co-delivery PMs. Such a system could control the multidrug to be released simultaneously or sequentially by special properties of tumour microenvironment (TME) (including acidic PH, redox, overexpressed enzyme, excessive temperature) and external environment trigger. Additionally, limitations, clinical translation and future perspectives of intelligent co-delivery PMs were also being discussed in this article.

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The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin

Cited by 42 publications

References 47 publications

Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption

Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption

Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo

Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

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