The effect of drugs on orthodontic tooth movement

Krishnan, Vinod; Davidovitch, Zéev

doi:10.1111/j.1601-6343.2006.00372.x

Cited by 89 publications

(63 citation statements)

References 47 publications

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“…[1][2][3] Bisphosphonates have been the most common prescribed medications for osteoporotic patients [4][5][6] and their effects on orthodontic tooth movement have been investigated in rat model. [7][8][9][10] Essentially, bisphosphonates are internalized into osteoclasts leading to inhibition of bone resorption and induction of osteoclast apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sirisoontorn

Hotokezaka

Hashimoto

et al. 2012

American Journal of Orthodontics and Dentofacial Orthopedics

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Section: Introductionmentioning

confidence: 99%

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sirisoontorn

Hotokezaka

Hashimoto

et al. 2012

American Journal of Orthodontics and Dentofacial Orthopedics

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“…14 As a result, the use of selective COX-2 inhibitors is increasing, replacing conventional NSAIDs in clinical practice, [6][7][8]22 although the specificity of coxibs can account for different effects of these drugs on tooth movement.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] The most common group of medications used in orthodontics for pain relief consists of nonsteroidal antiinflammatory drugs (NSAIDs). [6][7][8] These drugs function by inhibition of the enzyme cyclooxygenase (COX), which modulates the transformation of prostaglandins (PGs) from arachidonic acid in the cellular plasma membrane. 9 PGs, such as PGE1 and PGE2, are important mediators of bone resorption.…”

Section: Introductionmentioning

confidence: 99%

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

Gameiro

Noüer

Neto

et al. 2008

The Angle Orthodontist

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Objective: To test the hypothesis that short-and long-term celecoxib administration has no effect on orthodontic tooth movement. Materials and Methods: Male Wistar rats were submitted to short-(3 days) and long-term (14 days) celecoxib administration, while the respective control groups received equivolumetric saline intraperitoneal injections. The upper left first molars of all rats were moved mesially for 14 days by a fixed orthodontic appliance exerting 50 g force upon insertion. After the experimental period, tooth movement was quantified and tissues around the first molar were processed for tartrateresistant acid phosphatase (TRAP) histochemistry. The amount of tooth movement and the number of TRAP-positive cells on the alveolar bone surface were evaluated. Results: The amount of tooth movement was significantly reduced in rats submitted to short-and long-term celecoxib administration, while the number of osteoclasts on the alveolar bone did not differ between the four groups studied. Conclusions: The hypothesis is rejected. Although celecoxib administration did not affect the number of osteoclasts, the osteoclast activity might be reduced, which could explain the inhibition of tooth movement observed in the celecoxib-treated animals. These results indicate that orthodontists should be aware of patients under short-and long-term therapy with celecoxib.

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“…Bu ilaçlar diş gelişimi sırasında hücre içi metabolizmaya zarar verir ve hücre döngüsünü bozarak diş gelişimini olumsuz etkiler. 34,35 Kemoterapötik ilaçların diş ve oral dokulara etkisi alın-dığı yaş periyoduna bağlıdır. Sürekli dişlerin gelişim dö-neminde alınan kemoterapiye bağlı olarak mikrodonti görülebilirken, kök gelişimi sırasında alınan kemoterapi ile taurodont veya kısa köklü dişler oluşabilmektedir.…”

Section: çOcuk Hastalarda Kemoterapinin Diş Gelişimi üZerine Etkileriunclassified

Kemoterapi alan çocuklarda diş hekimliği yaklaşımı

Özmekik¹,

Ulukapi²

2014

Acta Odontol Turc

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ÖZET [Abstract in English is at the end of the manuscript] GİRİŞGünümüzde pediatrik hastalar kanser popülasyonunun önemli bir bölümünü oluşturmaktadır. Her yıl dünyada 160.000'den fazla çocuk kansere yakalanmaktadır. Birçok ülkede kanser kayıtları olmadığından, doğru sayı çok iyi bilinmemektedir. Kanser tanı ve tedavisindeki önemli gelişmelere rağmen gelişmiş ülkelerdeki kanserli çocukların %80'i iyileşirken, gelişmekte olan ülkelerde %50'sinden daha azını kurtarmak mümkün olmaktadır 1 . Ülkemizde ise her yıl 2.500-3.000 kadar çocukluk çağı kanseri beklenmektedir. Çocuklarda kanser erişkinlere kıyasla daha nadir olup, tüm kanserlerin %0.5'i 15 yaşından küçük çocuklarda görülmektedir. Bununla birlikte, tedavi başarısının yüksekliği ve çocukların önündeki beklenen yaşam süresinin uzunluğu, erken ve etkin tedaviyi, en iyi hizmete erişimi, yaşam kalitesini, psikososyal yaklaşımı daha da önemli hale getirmektedir.

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The effect of drugs on orthodontic tooth movement

Abstract: Drug-consumption history must be an integral part of every orthodontic diagnosis and treatment plan.

Cited by 89 publications

References 47 publications

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

Kemoterapi alan çocuklarda diş hekimliği yaklaşımı

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