Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Sirisoontorn, Irin; Hotokezaka, Hitoshi; Hashimoto, Megumi; Gonzales, Carmen; Luppanapornlarp, Suwannee; Darendeliler, M. Ali; Yoshida, Noriaki

doi:10.1016/j.ajodo.2011.11.016

Cited by 44 publications

(47 citation statements)

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“…27 Accordingly, it supposes that the same mechanism that causes the acceleration of induced tooth movement stimulates a more intense root resorption, and the opposite would also be true. Nevertheless, some studies confirm this assumption, 7,8 while others show that the mechanism that regulates tooth movement may be different from the mechanism of the root resorption. 6 Consequently, it would be possible to accelerate the teeth movement without increasing the root resorption.…”

Section: Low-level Laser On Orthodontically Induced Root Resorptionmentioning

confidence: 77%

Low-Level Laser Action on Orthodontically Induced Root Resorption: Histological and Histomorphometric Evaluation

et al. 2016

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Section: Low-level Laser On Orthodontically Induced Root Resorptionmentioning

confidence: 77%

Low-Level Laser Action on Orthodontically Induced Root Resorption: Histological and Histomorphometric Evaluation

et al. 2016

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“…Similar results were observed in the previous study. 12 On the other hand, the BMC and BV of the trabecular bone that were lowered by OVX gradually increased to reach normal levels in the OVX + ZOL group ( Figure 5E,F). Furthermore, in this study, the amount of OTM correlated with the trabecular bone parameters of tibia.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, OTM in the OVX + ZOL and control groups showed similar results, identical to the findings from our previous study. 12 …”

Section: Orthodontic Tooth Movementmentioning

confidence: 99%

“…Perilli et al 11 reported that treatment with ZOL as late as 2 weeks after ovariectomy (OVX) can still facilitate complete reversal of cancellous bone loss in rat tibia. Sirisoontorn et al 12 recently reported that OVX accelerated and ZOL inhibited OTM in rats. To date, no study has comprehensively examined OTM and quantitative bone changes in an osteoporotic animal model.…”

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confidence: 99%

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The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model

Hashimoto

Hotokezaka

Sirisoontorn

et al. 2013

The Angle Orthodontist

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Objective: To elucidate the effect of bone morphometric changes on orthodontic tooth movement (OTM) in zoledronic acid-treated ovariectomized rats. Materials and Methods: Twenty-one 10-week-old female Wistar rats were divided into ovariectomy (OVX), OVX with zoledronic acid administration (OVX + ZOL), and sham operation (control) groups. Two weeks after OVX, ZOL administration was initiated. Twelve weeks after OVX, a nickel-titanium closed-coil spring of 25-g force was applied mesially to the maxillary left first molar. In vivo micro-computed tomography (CT) of the left proximal tibia was performed for bone morphometric analysis every 2 weeks after OVX. In addition, OTM was investigated using micro-CT at 0, 12, and 14 weeks after OVX. Results: There were significant differences in the bone mineral content (BMC), bone volume (BV), BMC to tissue volume ratio (BMC/TV), and BV to TV ratio of trabecular bone between the control and OVX groups and also between the OVX + ZOL and OVX groups. In the OVX + ZOL group, increased BMC and BV in the cortical bone and increased bone mineral density (BMD) in the trabecular bone were observed. Interestingly, OTM in the OVX group was almost two times more than that in the control and OVX + ZOL groups. Moreover, OTM was correlated with BMD, BMC, BV, and BMC/TV in the trabecular bone. Conclusions: OVX accelerated OTM, while ZOL suppressed it. OTM demonstrated a significant negative relationship with trabecular bone mass. (Angle Orthod. 2013;83:766-773.)

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“…NSAIDs (diclofenac sodium,[2] indomethacin,[3] acetyl salicylic acid,[4] ibuprofen[5]), leukotrienes antagonist - zileuton,[6] phenytoin,[7] bisphosphonates (Bps),[891011121314151617181920] etc., are some important medical agents accountable for deceleration of OTM; contrary, local administered vitamin D,[21] parathyroid hormone hormones,[22] prostaglandins,[23] cytokines,[24] corticosteroids[25] (long-term use and dose dependent manner), etc., are accountable for acceleration of OTM.…”

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confidence: 99%

Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment

et al. 2014

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Introduction:Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits.Materials and Methods:Twenty rabbits were divided into two groups- “10” served as Group-1 (control) and other “10” as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1st, 7th, and 14th day of the experiment. A total of “40” lateral cephalograms were taken from both groups on the 1st and 21st day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animal's radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale.Results:The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).Conclusion:The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.

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Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid

Abstract: Introduction: The effect of zoledronic acid (ZOL), a potent and

Cited by 44 publications

References 45 publications

Low-Level Laser Action on Orthodontically Induced Root Resorption: Histological and Histomorphometric Evaluation

Low-Level Laser Action on Orthodontically Induced Root Resorption: Histological and Histomorphometric Evaluation

The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model

Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment

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