The effect of diuretics on cochlear potentials and inner ear fluids.

Silverstein, Herbert; Yules, Richard B.

doi:10.1288/00005537-197106000-00008

Cited by 63 publications

(14 citation statements)

References 12 publications

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“…Silverstein and Yules (16) found an increase in the sodium concentration of endolymph after ethacrynic acid was given to cats. Table IV shows similar lack of effect of a single dose of ethacrynic acid in the guinea pig.…”

Section: Methodsmentioning

confidence: 99%

The Mutual Independence of the Endolymphatic Potential and the Concentrations of Sodium and Potassium in Endolymph

Brusilow¹,

Gordes²

1973

J. Clin. Invest.

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A B S T R A C T The relationship between the endolymphatic potential (EP) and the sodium and potassium concentration gradients between endolymph and interstitial fluid was studied both by measuring the EP at varying concentrations of sodium and potassium in endolymph and by measuring the effect of a depressed EP on the concentrations of these cations. Ethacrynic acid was used in dogs to change the concentration of sodium and potassium (meq/liter) in endolymph from 5.8 and 148 to 134 and 24.3, respectively. No change in the EP accompanied these alterations. In a second series of experiments the EP was reduced from + 72 mV to + 31 mV for a mean duration of 20 min. No change in the concentration of sodium and potassium in endolymph was found during the period of reduced EP. These data suggest that there is little relationship between the EP and the sodium and potassium concentrations in endolymph. INTRODUCTIONVon Bekesy (1) discovered that the endolymphatic potential (EP) 1 is + 75 mV and Smith, Lowry, and Wu (2) showed that the potassium concentration in endolymph is approximately 150 meq/liter and the sodium concentration is less than 20 meq/liter. It has also been reported that the chloride concentration (3) and pH

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Section: Methodsmentioning

confidence: 99%

The Mutual Independence of the Endolymphatic Potential and the Concentrations of Sodium and Potassium in Endolymph

Brusilow¹,

Gordes²

1973

J. Clin. Invest.

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“…Experimental studies have shown that these diuretics cause a de crease in the endocochlear potential [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ototoxic Diuretics (Loop Diuretics) on the Endolymphatic Sac

Erwall¹,

Friberg²,

Bagger‐Sjöbäck³

et al. 1988

ORL

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The acute and chronic effects of treatment with ethacrynic acid (EA) and furosemide (FU) on the structure of the murine endolymphatic sac were studied by means of light and transmission electron microscopy. The animals were treated with loop diuretics in doses which are known to cause morphological alterations of the stria vascularis and a significant reduction of the endocochlear potential. A single intravenous injection of either EA or FU resulted in immediate morhpological changes such as an increase in cytoplasmic contents of endoplasmic reticulum and more prominent Golgi structures of the light cells. These cells developed membrane-bound granules and a smooth tubular network in the apical cytoplasm. These findings together with the appearance of a precipitate on the luminal aspect of the cell membrane suggested secretory activity. Ten days after daily intraperitoneal injections with loop diuretics in sub toxic doses, the epithelial cytoarchitecture of the endolymphatic sac was altered, with pronounced veiling of the light cells by the dark cells. It is concluded that the changes in the endolymphatic sac epithelium after treatment with ototoxic diuretics may not be a result of a primary toxic effect on the sac per se, but rather be secondary to alterations in fluid and ion homeostasis in the rest of the inner ear.

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“…The observed low sensitivity of the Na-K-ATPase system in the stria vascularis to ethacrynic acid ( fig. 1 a, b), its deleterious effect on cochlear physiology and structures (Quick and Duvall, 1970;Nakai, 1971;Silverstein and Yules, 1971) together with the findings in other tissues, suggest that the ototoxic effect of ethacrynic acid is due to an interference with several aspects of the metabolism of the stria vascu laris and hair cells.…”

Section: Discussionmentioning

confidence: 92%

“…Changes in the ionic composition of the endolymph, as well as depressive effects on the cochlear potentials had been demonstrated by many authors {Cohn et al., 1971;Silverstein and Yules, 1971;Prazma et al, \912\Dilling et al, 1973;Bosher et al, 1973;Thalmann et al, 1973;Sellick and Johnstone, 1974). Prazma et al (1972) concluded from their experiments that the delete rious effect of ethacrynic acid on the cochlear potentials was due to an inhibi tion of the active cation transport system.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ouabain and Ethacrynic Acid on ATPase Activities in the Inner Ear of the Rat and Guinea Pig

Kuijpers

Wilberts

1976

ORL

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The effect of ethacrynic acid on ATPase activities in the stria vascularis of rat and guinea pig inner ear was studied. Both Na-K- and Mg-activated ATPase activities were inhibited non-selectively only at very high concentrations of ethacrynic acid, in contrast to the selective inhibition of Na-K-ATPase activity by ouabain. It is suggested that the deleterious effect of ethacrynic acid on the inner ear may be due to its effect on the general metabolism of the cell rather than on the ionic transport system.

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The effect of diuretics on cochlear potentials and inner ear fluids.

Cited by 63 publications

References 12 publications

The Mutual Independence of the Endolymphatic Potential and the Concentrations of Sodium and Potassium in Endolymph

The Mutual Independence of the Endolymphatic Potential and the Concentrations of Sodium and Potassium in Endolymph

Effects of Ototoxic Diuretics (Loop Diuretics) on the Endolymphatic Sac

The Effect of Ouabain and Ethacrynic Acid on ATPase Activities in the Inner Ear of the Rat and Guinea Pig

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