The Effect of Different Parameter on the Flow Response of Microfluidic-Based Acoustic Sensor

Rahman, Mohamad Faizal Abd; Arshad, Mohd Rizal; Manaf, Asrulnizam Abd; Sidek, Othman

doi:10.1016/j.proeng.2012.07.167

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…We developed the in vitro platforms to apply mechanical stimuli to cells in a 3D microenvironment and in a liquid suspension culture system. A pressurization chamber was manufactured from PDMS owing to its non-cytotoxic properties and its acoustic impedance characteristics promoting efficient transmission of the stress pulses at the chamber-cell environment interface [61]. We considered cost, optical clarity, and ease of manufacture and sterilization in the design of the in vitro platforms [57][58][59].…”

Section: Discussionmentioning

confidence: 99%

“…The primary design parameters of the pressurization chambers were: (1) the high-efficiency transmission of the stress pulses from the loading apparatus to the biological sample; (2) to act as a physical barrier and, thus, keep the biological sample under sterile conditions during the compressive loading; (3) to preserve the mechanical integrity of the biological sample throughout the successive steps of the experimentation. a Extracted from [61]. Data expressed as mean ± SD.…”

Section: Development Of a Pressurization Chambermentioning

confidence: 99%

“…Most importantly, its acoustic impedance characteristics close to water and highcontent water substrates (e.g. agarose hydrogel) made it an attractive candidate for the efficient transmission of the stress waves across the chamber-sample interface [61].…”

Section: Development Of a Pressurization Chambermentioning

confidence: 99%

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Replicating landmine blast loading in cellular in vitro models

et al. 2020

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Trauma arising from landmines and improvised explosive devices promotes heterotopic ossification, the formation of extra-skeletal bone in non-osseous tissue. To date, experimental platforms that can replicate the loading parameter space relevant to improvised explosive device and landmine blast wave exposure have not been available to study the effects of such non-physiological mechanical loading on cells. Here, we present the design and calibration of three distinct in vitro experimental loading platforms that allow us to replicate the spectrum of loading conditions recorded in near-field blast wave exposure. We subjected cells in suspension or in a three-dimensional hydrogel to strain rates up to 6000 s−1 and pressure levels up to 45 MPa. Our results highlight that cellular activation is regulated in a non-linear fashion—not by a single mechanical parameter, it is the combined action of the applied mechanical pressure, rate of loading and loading impulse, along with the extracellular environment used to convey the pressure waves. Finally, our research indicates that PO MSCs are finely tuned to respond to mechanical stimuli that fall within defined ranges of loading.

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Section: Discussionmentioning

confidence: 99%

Section: Development Of a Pressurization Chambermentioning

confidence: 99%

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Replicating landmine blast loading in cellular in vitro models

et al. 2020

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“…Smaller microchannel will reduce the overall size of the device, also becomes more sensitive to the absorption. 10 The performance of microchannel depends on the size of microchannel 11 and the electrolyte inside the microchannel. The important properties such as low surface tension, and low viscosity were considered in the selection of electrolyte.…”

Section: 10 Introductionmentioning

confidence: 99%

Modeling of Novel Microfluidic based Flow Sensor Inspired from Fish Canal Neuromast for Underwater Sensing

Nawi

2013

Jurnal Teknologi

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Modeling of the microfluidic based flow sensor that inspired from the canal neuromast in the fish lateral line system has been presented in this paper. The structure of the sensor consists of the dome-shaped membrane integrated with the microchannel which is filled with electrolyte. The analysis on the model was carried out using the computational fluid dynamic and finite element method. Based on the simulation, higher performance can be achieved by increase the outer radius and decrease the ratio of the radius of the dome-shaped membrane. The PDMS material was suggested for this sensor because of its advantages that is easily deformed and suitable to implement as membrane. We proposed using the microfluidic technology as a sensing element because of the simple structure and ease to fabricate compare to the common sensing element such as piezoresistive and strain gage.

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