The effect of dietary omega-3 polyunsaturated fatty acids on plasma lipids and lipoproteins of C57BL/6 mice is age and sex specific

Balogun, Kayode; Randunu, Raniru Sergaevna; Cheema, Sukhinder Kaur

doi:10.1016/j.plefa.2014.05.002

Cited by 16 publications

(11 citation statements)

References 120 publications

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“…Even though previous literature investigating the effect of n -3 PUFAs and their effects on cholesterol efflux routes and RCT is still ambiguous, it has been clearly shown that n -3 PUFAs promote the RCT mechanism. Using an established RCT model, in which ( 3 H)-labeled macrophages are injected into the peritoneal cavity of animals—where the appearance of a tracer in plasma and feces is monitored—different laboratories have demonstrated that n -3 PUFAs promote macrophage-to-feces RCT in rodents [ 27 , 28 , 29 ]. In human macrophages, in turn, n -3 PUFAs have been shown to significantly increase cholesterol efflux from macrophages [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review

et al. 2017

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The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular disease have been studied extensively. However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). RCT describes a mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. The aim of this review is to summarize the literature and to provide an updated overview of the effects of n-3 PUFAs on key players in RCT, including apoliprotein AI (apoA-I), ATP-binding cassette transporter A1 (ABCA1), ABCG1, apoE, scavenger receptor class B type I (SR-BI), cholesteryl ester transfer protein (CETP), low-density lipoprotein receptor (LDLr), cholesterol 7 alpha-hydroxylase (CYP7A1) and ABCG5/G8. Based on current knowledge, we conclude that n-3 PUFAs may beneficially affect RCT, mainly by influencing high-density lipoprotein (HDL) remodeling and by promoting hepatobiliary sterol excretion.

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Section: Introductionmentioning

confidence: 99%

The Role of Omega-3 Fatty Acids in Reverse Cholesterol Transport: A Review

et al. 2017

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“…These data are consistent with [52] who explained that OMG-3 fatty acids exert potential hypocholesterolemic effect through inhibition of key enzymes related to cholesterol synthesis and transfer such as 3-Hydroxy-3-methylglutaryl reductase and acyl-CoA: cholesterol acyltransferase and selectively lower triglycerides by increasing glucose flux to glycogen, increasing mitochondrial β-oxidation, and decreasing triglycerides synthesis, an effect that is mediated partially by PPAR-a activation. Furthermore; [53] revealed that NEFAs are substrate for TG synthesis and suggested that the TG lowering effect of n-3 PUFA could be due to an increased stimulation of β-oxidation, which leads to a decrease in available NEFA for TG formation. They also stated that HDL-2 and HDL-3 are the most characterized HDL subclasses, and HDL-2 involved in scavenging more cholesterol from the peripheral tissues compared to HDL-3.…”

Section: Effects Of Gte and Omega-3 On Serum Lipid Profile And Mdamentioning

confidence: 99%

Influence of Omega-3 and Green Tea Extract on Alcohol-Induced Liver Injury in Rats

Hussein

Ibrahim

2018

KJAR

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Drinking alcoholic beverages recently is common in many parts of the world, liver is a principal organ that involved in toxic effects of alcohol and it remains a serious health problem globally. Fatty liver (steatosis) was induced in male albino rats by alcohol 40% orally (3.76gm/kgm BW/day) for the period of 4 weeks, then green tea extract (GTE) and omega-3 (OMG-3) fish oil were used as treatments for improvement and investigating their comparison potential role for the next 4 weeks. At the end of the experiment, the rats were fasted overnight, blood samples through the cardiac puncture and liver organ were collected for biochemical and histopathological analysis respectively. Biochemical parameters including: lipid profiles: (total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C), serum malondialdehyde (MDA), liver function tests (LFT): (Serum albumin (ALB), serum total protein (TP), total serum bilirubin (TSB), serum alkaline phosphatase (ALP), serum alanine aminotransferase (ALT), and serum aspartate aminotransferase (AST) and finally hepatic histological changes were also investigated. Alcoholic rats were associated with significant elevation (P<0.05) in the levels of serum TC, TG, LDL-C, MDA, TSB, ALT, AST and ALP, whereas the levels of serum HDL-C and TP significantly (P<0.05) decreased with no significant change (P>0.05) of serum ALB level. treatment of alcohol-fed rats with GTE and OMG-3 oil either alone or in their combination have significant role (P<0.05) in lowering the injury effects of alcohol evidenced by reversing the results obtained on serum lipid profiles, MDA, LFTs and hepatic histological changes after their treatments during the amelioration study. Ethanol consumption impaired hepatic functions, disturbed lipid metabolism, induced hyperlipidemia and increased oxidative stress. Aqueous extracts of GT and OMG-3 oil significantly improved alcohol-induced liver injury through improvement of serum markers of hepatic injury, their hypolipidemic actions and hepatic histologic recovery. Co-treatments of GT+OMG-3 have more protective effect or faster progression against ALD than their treatments alone.

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“…A recent randomized controlled trial of 60 ICU sepsis patients demonstrated a significant improvement in organ failure after intravenous administration of 10% fish oil 24 . Omega‐3 fatty acids have also been shown to improve several critical HDL functions including HDL‐ApoA‐I‐exchange, 32,33 reverse cholesterol transport, 34–37 and antioxidant functions of HDL and paraoxonase‐1 (PON‐1) activity 34 . Finally, fish oil lipid emulsions may safely elevate cholesterol levels 38 .…”

Section: Introductionmentioning

confidence: 99%