The effect of dietary lipids and antioxidants on the activity of epoxide hydratase in the rat liver and intestine

Gower, Jon D.; Sayer, Jeremy; Wills, Eric D.

doi:10.1016/0006-2952(86)90728-8

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…That lipid type governs the toxicokinetics of ingested FLA is also supported by published reports on the association between the biotransformation enzymes and PAHs incorporated in dietary lipids. A positive correlation between the content of polyunsaturated fatty acids in the diet and hepatic and intestinal epoxide hydrolase (the key enzyme involved in FLA metabolism; [28]) activity subsequent to PAH administration through diet has been reported [29,30]. In this context, it is worth mentioning that epoxide hydrolase has been detected in several rat organs and tissues (reviewed in Ref.…”

Section: Discussionmentioning

confidence: 98%

Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene☆

Walker

Addai

Mathis

et al. 2007

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 98%

Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene☆

Walker

Addai

Mathis

et al. 2007

The Journal of Nutritional Biochemistry

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Nutritional factors of microsomal enzymatic induction: influence of lipidic components of the diet

Mounié¹,

Goudonnet²,

Prevost³

et al. 1990

Eur. J. Drug Metab. Pharmacokinet.

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We compared the ability of two different diets containing 6 per cent of maize oil and 6 per cent of fish oil to modify: firstly the enzyme induction by phenobarbital and secondly the phenobarbital hydroxylation by the liver either in vivo or during in vitro perfusions. The presence of fish oil in the diet increased the cyt P 450 content and the bilirubin glucuronosyl transferase activity. The two induction effects promoted by the association of the phenobarbital treatment and the eating of the fish oil were not additive and it was found that the phenobarbital induction effect was decreased by the fish oil consumption. Phenobarbital and p-hydroxyphenobarbital kinetics were different in the two groups of animals. Phenobarbital was more slowly eluted in the fish oil fed than in the maize oil fed rats while p-hydroxyphenobarbital was more slowly eluted by the fish oil-fed rat livers.

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Dietary lipids induce Phase 2 enzymes in rat small intestine

Dannenberg

Yang

Aharon

1993

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metaboli

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The effect of dietary lipids and antioxidants on the activity of epoxide hydratase in the rat liver and intestine

Cited by 9 publications

References 20 publications

Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene☆

Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene☆

Nutritional factors of microsomal enzymatic induction: influence of lipidic components of the diet

Dietary lipids induce Phase 2 enzymes in rat small intestine

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