The Effect of Diabetes of Pancreatectomy on the Pituitary Cytology of Dogs1

Gregory, Raymond; Drager, Glenn A.; Tsai, Shih Yuan; May, L.G.; White, Virginia A.; Bennett, Alene; Gregory, Charles C.

doi:10.1210/endo-58-1-79

Cited by 4 publications

(1 citation statement)

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“…Possibly, only a limited proportion might be affected or response-thresholds of various elements might differ considerably. That some cellular components may be altered is suggested by the reported occurrence of basophilic changes in the pituitaries of totally pancreatectomized dogs (41). Second, the precise relationship between hypophyseal carbohydrate metabolism and intrapituitary turnover of hormones remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Studies of Anterior Pituitary Tissue in Vitro: Effects of Insulin and Experimental Diabetes Mellitus Upon Carbohydrate Metabolism*

Goodner¹,

Freinkel²

1961

J. Clin. Invest.

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Since the classical experiments of Houssay and Biasotti (1), Evans, Meyer, Simpson and Reichert (2), Young (3), and Long and Lukens (4), the diabetogenic potential of pituitary hormones has been amply documented (5). However, the metabolism of glucose by the pituitary has received but little examination (6-9), and the authors have been unable to find any published studies of the hormonal determinants of hypophyseal carbohydrate economy. Because of the potential contribution of these factors to the endocrine function of the pituitary, experiments were initiated to define the role of insulin. The studies have demonstrated that the assimilation and disposition of glucose by surviving preparations of anterior pituitary from normal rats and beef may be enhanced by insulin in vitro. Moreover, it has been shown that glucose metabolism is significantly reduced in anterior pituitaries excised from rats rendered insulin-deficient by total pancreatectomy or alloxanization, and that these hypophyseal derangements can be prevented by replacement therapy with insulin in vivo. METHODS

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Section: Discussionmentioning

confidence: 99%