The effect of diabetes mellitus on the prevalence of rheumatoid arthritis: a case–control study

Tentolouris, Nikolaοs; Arapostathi, Christina; Voulgari, Christina; Grammatikou, Sofia; Andrianakos, A.; Sfikakis, Petros P.

doi:10.1111/j.1464-5491.2008.02487.x

Cited by 6 publications

(7 citation statements)

References 7 publications

(9 reference statements)

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“…Tentolouris et al tested the hypothesis that patients with pre-existing DM might have a lower RA prevalence than the general population because of immunosuppression associated with DM 44. Although their study results did not prove their hypothesis, they suggested that it may easily reach statistical significance when the number of patients with type 2 DM increased to 1500 44. Clearly, additional cohort studies are warranted to validate this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study

Huang²,

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study

Huang²,

et al. 2012

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“…Based on the above we examined previously the hypothesis that pre-existing hyperglycemia may have a protective effect on the development of RA (11), a disease in which the earliest event is an intense inflammatory response to unknown stimuli within the joint. In a preliminary study we found that in patients with type 1 DM (T1DM), which coexists with other autoimmune diseases including RA (12), the prevalence of RA was higher in patients with T1DM compared with age-and gender-matched controls without DM (0.58% vs. 0.39%, respectively) (11). In contrast, RA prevalence was lower in patients with type 2 DM (T2DM) (0.25% vs. 0.83% in controls), albeit the difference did not reach statistical significance (11).…”

Section: R H E U M a T O I D A R T H R I T I S ( R A ) I S T H E M O mentioning

confidence: 99%

“…In a preliminary study we found that in patients with type 1 DM (T1DM), which coexists with other autoimmune diseases including RA (12), the prevalence of RA was higher in patients with T1DM compared with age-and gender-matched controls without DM (0.58% vs. 0.39%, respectively) (11). In contrast, RA prevalence was lower in patients with type 2 DM (T2DM) (0.25% vs. 0.83% in controls), albeit the difference did not reach statistical significance (11). Apart from our study, there are a few previous studies that have examined the relationship between DM and RA with conflicting results (13)(14)(15).…”

Section: R H E U M a T O I D A R T H R I T I S ( R A ) I S T H E M O mentioning

confidence: 99%

Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus

Tentolouris¹,

Thanopoulou²,

Tentolouris³

et al. 2018

Ann. Transl. Med

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Background: Type 2 diabetes mellitus (T2DM) is a non-autoimmune disease characterized by chronic hyperglycemia and increased non-enzymatic glycation of amino groups. Glycation occurs through a series of events eventually leading to the formation of irreversible "advanced glycation end-products" (AGEs). AGEs may affect the function of long-lived proteins, including cytokines, immunoglobulins and their receptors, resulting in a "less active" immune system. We aimed to test the hypothesis that a common inflammatory chronic disease, such as rheumatoid arthritis (RA), in which the earliest event is an inflammatory response to unknown stimulus, has a lower prevalence in these patients than in normoglycemic, non-diabetic subjects. Methods: In this study, we compared the prevalence of RA in a prospectively followed outpatient cohort of patients with T2DM patients (n=1,630) with a control, matched, non-diabetic population (n=1,630). Results: Among non-diabetic controls, 13 patients (prevalence 0.80%) with RA were identified. An almost 3-fold lower prevalence of RA (0.25%) was found in consecutive patients with T2DM (P=0.029). Most of the RA cases among participants with T2DM were diagnosed early after diabetes onset. The onset of RA in patients with T2DM occurred at significantly older age (64±15 years) as compared to the non-diabetes group (48±18 years; P=0.004). Conclusions: The prevalence of RA is lower and occurs in an older age in patients with pre-existing T2DM in comparison with people without T2DM.

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“…We also found a similar protective effect of treated DM on RA risk in our previous study [ 24 ]. Possible explanations included an immunosuppressive effect by hyperglycemia [ 32 ], or possible immunomodulatory effects of some anti-diabetic drugs [ 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study

et al. 2017

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ObjectiveTo estimate the association between a history of periodontitis (PD) and the risk of incident palindromic rheumatism (PR).MethodsUsing a nationwide, administrative database, this study identified 4,421 newly-diagnosed PR cases from 2007 to 2012 and randomly selected 44,210 non-PR controls matched (1:10) for sex, age and the year of the index date. After adjusting for comorbid diabetes mellitus, we estimated the odds ratios (ORs) with 95% confidence intervals (CIs) using conditional logistic regression analysis to quantify the association between a history of PD and the risk of PR. The influences of the lag time and severity of PD were examined by calculating ORs for subgroups of patients based on the time interval between the last PD-related visit and the index date and PD-related cumulative cost and number of visit.ResultsThis study showed an association between a history of PD and incident PR (OR, 1.51; 95% CI, 1.41–1.61). The association remained significant after variation of PD definitions. The magnitude of the association was greater in those with shorter lag time between the latest date of PD diagnosis and PR index date and those who had a higher number of visits for PD or a greater cumulative cost for PD-related visits. After excluding 569 PR patients who developed rheumatoid arthritis after the index date, we found a consistent time- and dose-dependent association between PD and PR risk.ConclusionThis study demonstrated a time- and dose-dependent association between PD exposure and PR risk.

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The effect of diabetes mellitus on the prevalence of rheumatoid arthritis: a case–control study

Cited by 6 publications

References 7 publications

Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study

Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study

Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus

Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study

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