The effect of detomidine (Domosedan) on the maintenance of equine pregnancy and foetal development: ten cases

Katila, Terttu; Oijala, Mari

doi:10.1111/j.2042-3306.1988.tb01536.x

Cited by 15 publications

(4 citation statements)

References 8 publications

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“…In cattle, xylazine increases intrauterine pressure and is believed to have abortigenic capabilities [87]. In horses, no specific effects of the drug were detected in eight mares given 20 lg/kg/wk from day 14 to day 60 of gestation and then every 4 weeks until parturition [80]. Similarly, repeated detomidine doses caused temporary (90-minute duration) decreases in fetal heart rates but had no observed detrimental effects on the pregnancy [96].…”

Section: Broodmares and Neonatesmentioning

confidence: 95%

Management of gastrointestinal pain

Malone

Graham

2002

Veterinary Clinics of North America: Equine Practice

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Choice of an analgesic for gastrointestinal pain requires consideration of the cause of the pain, desired duration of pain relief, need for sedation, and potential side effects and toxicity, particularly in light of other drugs being used and effects on the gastrointestinal tract. It is imperative that close monitoring be continued to ensure that surgical lesions or worsening conditions are detected. Recent research in the field may lead to new drugs, drug combinations, and avenues of treatment that minimize the side effects of these drugs while maximizing their efficacy.

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Section: Broodmares and Neonatesmentioning

confidence: 95%

Management of gastrointestinal pain

Malone

Graham

2002

Veterinary Clinics of North America: Equine Practice

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“…Special concern has been raised about the capture and immobilisation of pregnant females, as drugs may reduce reproductive output and survival rate of offspring. Indeed, α2-agonists drugs were observed to affect bovine uterine contractility [ 39 ], and repeated doses were reported to cause abortion in horses [ 40 ]. Sakamoto et al [ 41 ] found that administration of xylazine to pregnant goats results in an alteration of the physiological parameters of both mother and foetus (i.e., decrease in uterine blood flow caused by the induction of uterine contractions, decrease in circulating blood volume, hypoxemia and acidosis in the mother) that may lead to abortion.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Impact of Capture on Wild Animals: The Case Study of Chemical Immobilisation on Alpine Ibex

et al. 2015

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The importance of capturing wild animals for research and conservation projects is widely shared. As this activity continues to become more common, the need to assess its negative effects increases so as to ensure ethical standards and the validity of research results. Increasing evidence has revealed that indirect (physiological and behavioural) effects of capture are as important as direct risks (death or injury) and that different capture methodologies can cause heterogeneous effects. We investigated the influence of chemical immobilisation on Alpine ibex (Capra ibex): during the days following the capture we collected data on spatial behaviour, activity levels of both males and females, and male hormone levels. Moreover, we recorded the reproductive status of each marked female during the breeding seasons of 15 years. Then, by several a priori models we investigated the effects of the capture taking into account biological factors and changes in environmental conditions. Our results showed that chemical immobilisation did not affect either spatial behaviour (for both males and females) or male hormone levels, though both sexes showed reduced activity levels up to two days after the capture. The capture did not significantly affect the likelihood for a female to give birth in the following summer. Our findings highlighted the scarce impact of chemical immobilisation on ibex biology, as we detected alteration of activity levels only immediately after the capture if compared to the following days (i.e., baseline situation). Hence, the comparison of our findings with previous research showed that our methodology is one of the less invasive procedures to capture large mammals. Nonetheless, in areas characterised by high predator density, we suggest that animals released be carefully monitored for some hours after the capture. Moreover, researchers should avoid considering data collected during the first days after the manipulation in order to avoid biased information.

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“…In pregnant mares, uterine electrical activity remained constant or decreased (Jedruch et al 1989). No consistent effects on the outcome of pregnancy were observed in a study in which detomidine was frequently administered to pregnant mares (Katila and Oijala 1988). However, only 6 foals were weaned from 10 pregnancies, but no similarities were noted between the other 4 cases.…”

Section: Introductionmentioning

confidence: 92%

Some effects of multiple administrations of detomidine during the last trimester of equine pregnancy

Luukkanen¹,

Katila²,

Koskinen³

1997

Equine Veterinary Journal

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Summary Detomidine was given to 11 pregnant mares at 3 week intervals during the last trimester of pregnancy. Maternal and fetal electrocardiographs were recorded and fetal activity studied by transabdominal ultrasonography, before and 2 h (2, 5, 10, 20, 30, 60, 90 and 120 mini after injection. After parturition, the foals were examined and weighed. Maternal and fetal hearts rate showed an initial decline after detomidine administration. Maternal heart rate in the treatment group were lower already 2 min after injection, but a reduction in fetal heart was first seen 5 min after detomidine administration. Mean fetal heart rate at 2 min after detomidine injection was 109, 104, 95 and 89 beats/min, whereas at 5 min it was 80,76,72 and 66 beats/min in the 2nd, 3rd, 4th and 5th examination session, respectively. The heart rates did not revert to the control values during follow‐up. Decline and recovery patterns were quite similar during all examination sessions. The mares exhibited conductive disturbances 2 min after detomidine administration, but fetal heart rhythm remained regular. Fetal activity was decreased at 5 min but had reverted to control values about 90 min after detomidine administration. Administration of detomidine (0.015 mg/kg) to healthy pregnant mares at 3 week intervals during the last trimester had no measurable detrimental effects on the outcome of pregnancy.

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The effect of detomidine (Domosedan) on the maintenance of equine pregnancy and foetal development: ten cases

Cited by 15 publications

References 8 publications

Management of gastrointestinal pain

Management of gastrointestinal pain

Assessing the Impact of Capture on Wild Animals: The Case Study of Chemical Immobilisation on Alpine Ibex

Some effects of multiple administrations of detomidine during the last trimester of equine pregnancy

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